Friday, May 22, 2009, 11:00 am — John Dunn Seminar Room, Bldg. 463
With the advent of high-throughput sequencing technologies, sequencing has become an effective means of understanding life systems and increasing their utility. There is no doubt that sequence information is not only the final goal of a particular genome/metagenome project but a starting point of so-called ‘-omics’ research, becoming the cornerstone of systems biology and synthetic biology. There have been hundreds of microbial genome projects, including derivatives of Escherichia coli B that have been widely used as a workhorse in the labs and industry. Recently, we determined partly as an international consortium activity the genome sequences of two E. coli strains of the B lineage, REL606 and BL21(DE3). We further integrated and compared the transcriptome, proteome and phenome data of B and K-12, and also applied a computational modeling approach, thus providing a framework to elucidate the phenotypic characteristics of organisms and offering a high-resolution system-wide view of the biological systems.
Hosted by: Bill Studier
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