Tuesday, September 22, 2009, 11:00 am — John Dunn Seminar Room, Bldg. 463
Genomic maintenance and accurate replication are absolute requirements for life. Richard Setlow's seminal discovery of excision-repair forty-five years ago has spurred the remarkable expansion of the field of DNA repair and its relationships to human disease and aging. Many DNA repair pathways have now been revealed, including the subpathway of transcription-coupled DNA repair, which will be discussed in detail. The transcriptional processing of non-canonical DNA structures will also be considered.
Examples of crosstalk and overlap between different pathways for processing damaged DNA have emerged. Each step in a repair pathway generates an intermediate that constitutes another lesion, which may be susceptible to intervention by enzymes from other pathways. Thus, there may be decision points at each stage of repair until DNA integrity is finally reestablished. The outcome for the cell and for the organism of which it is a part may depend upon which protein encounters the lesion first.
Hosted by: Carl Anderson
5766 | INT/EXT | Events Calendar
Not all computers/devices will add this event to your calendar automatically.
A calendar event file named "calendar.ics" will be placed in your downloads location. Depending on how your device/computer is configured, you may have to locate this file and double click on it to add the event to your calendar.
Event dates, times, and locations are subject to change. Event details will not be updated automatically once you add this event to your own calendar. Check the Lab's Events Calendar to ensure that you have the latest event information.