Friday, January 7, 2011, 11:00 am — John Dunn Seminar Room, Bldg. 463
Eukaryotic complexity is, in large part, an outcome of the interplay between genetic (DNA sequence) and epigenetic (covalent DNA and histone modifications) layers of gene control. The model plant Arabidopsis thaliana represents an excellent model system to study epigenetic control of genes and genomes given the full complement of DNA and histone modifications present in its epigenomes throughout ontogeny. I will present results showing how Arabidopsis heterochromatin, composed mainly of transposon sequences, becomes reprogrammed in immortalized plant cells grown in culture, in inter-specific hybrids, as well as during normal germ line development. These events of 'genome shock' lead to reprogramming of DNA and histone methylation patterns and gene expression, which, as we show, is regulated by RNAi and is characterized by appearance of a novel class of small RNA molecules. These changes in epigenetic imprints throughout the genome, both in transposons as well as in genes nearby, have important implications for somatic and trans-generational inheritance of gene expression programs as well as genome stability and genome evolution.
Hosted by: John Dunn
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