NSLS-II Seminar

Using state-of-the-art nanofabrication, phase zone plates suitable for hard-x-rays, sub-20 nm resolution can now be obtained with ease. Ongoing developments in the instrumentation and reconstruction algorithms continue to improve the nanometer scale resolution x-ray imaging in 3D and non-destructive way. Review of this advent of this technology, its application to various domains in science, the relevance to the nanoscience and nanotechnology will be presented. Specifically, an effort to take full advantage of the power of x-ray imaging to look into deep and fine structures, such as the study of the microvascular structure in details and in different aspects relevant to the tumor angiogenesis. The high lateral and temporal resolution of x-ray microscopies are exploited in an optimal way to achieve the detailed understanding of the microangiogenesis process and benefit the drug development based on the anti-angiogenesis strategy. The key factors enable such capability are the effective integration of research community in biology, medicine, physics and chemistry. In particular, the proper animal handling, the selection of relevant animal models, the application of nanomedicine as labeling and contrast agents attributed to the first successful exploration of the imaging capability offered long ago by SR x-ray microscopy. This presentation will focus on course of the development in the instrumentation and experiments with special emphasis on the nanomedicine, nanofabrication and nanosynthesis made possible by synchrotron x-rays.