Friday, January 6, 2012, 11:00 am — John Dunn Seminar Room, Bldg. 463
Polycomb Group protein (PcG) genes encode epigenetic repressors that regulate many aspects of eukaryotic development via histone modification. In Arabidopsis, Polycomb Repressor Complex 2 (PRC2), made of PcG proteins, catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) and PRC1-like proteins catalyze H2AK119 ubiquitination. Despite functional similarity to PcG proteins, EMBRYONIC FLOWER1 (EMF1) lacks sequence homology with known PcG proteins; thus its role in the PcG mechanism is unclear. To study the EMF1 functions in the PcG mediated gene silencing mechanism, we performed genome-wide mapping of EMF1 binding and H3K27me3 in Arabidopsis seedlings. These results, coupled with H3K27me and transcriptome in emf1 and PRC2 mutants, showed that EMF1 represses gene activity via diverse mechanisms and plays a novel role in the PcG mechanism.
Hosted by: John Shanklin
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