Friday, February 10, 2012, 11:00 am — John Dunn Seminar Room, Bldg. 463
Recent advances in genomic technologies have enabled the identification of genetic variants for hundreds of species. Although progress is being made in linking genetic variants to phenotype, many remain elusive. One source of natural variants currently being overlooked is epigenetic alleles (epialleles). Epialleles often exhibit changes in their DNA methylation status, which is not trivially identified, and as a result, very few epialleles have been uncovered across kingdoms. We have sequenced the genomes, methylomes and transcriptomes of hundreds of Arabidopsis thaliana accessions isolated from regions across the northern hemisphere to better understand the interplay and impact of natural genetic, epigenetic and transcriptional variation on phenotypic diversity. In this population we have identified thousands of differentially methylated regions, some of which are associated with genetic variants whereas others have occurred spontaneously and independently of genetic variation. My future goals include understanding epiallele formation and determining how epialleles shape phenotypic variation.
Hosted by: John Shanklin
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