Wednesday, March 7, 2012, 4:00 pm — Stony Brook University, Physics building room S240
It was shown in the early 1990s at the X17B1 superconducting wiggler beamline of the National Synchrotron Light Source (NSLS), Brookhaven National Laboratory that array of parallel, thin (25 to 90-μm thick) planes of synchrotron x rays (called microbeams) are tolerated by normal tissues in rats at up to very high doses (Slatkin et al., PNAS 1995). Within the next ten years the effect was confirmed in several other animal models both at the NSLS and at the European Synchrotron Radiation Facility (ESRF). In the mid 2000s it was shown at the NSLS that a) arrays of microbeams as thick as 680 μm (called minibeams) still retain much of their tissue-sparing effect, and b) two arrays of parallel, horizontal minibeams aimed at the target from 90º angles can be “interleaved” to produce a solid radiation field at the target (Dilmanian et al, PNAS 2006). I will present our a) interleaved x-ray minibeam studies that successfully treated a high-grade glioma rat brain tumor model, and b) application of arrays of vertical microbeams to treat a model of rat spinal cord contusion injury.
Hosted by: Peter Stephens
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