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  1. Center for Functional Nanomaterials Seminar

    "Nanoarchitectures and bioengineering tools made from DNA"

    Presented by Thorsten-Lars Schmidt, PhD, Kent State University

    Friday, February 21, 2020, 10 am
    Bldg. 735, Conference Room A, 1st Floor

    Hosted by: Oleg Gang

    DNA is a unique polymer. It is the information storage molecule of all known life forms, and can be used to build up almost arbitrary structures and patterns from DNA. These structures can site-specifically be functionalized with a large variety of inorganic nanoparticles, small molecules or large biomolecules such as proteins and antibodies. Our group is leveraging this programmability to engineer nanoarchitectures and tools for applications in Biophysics, Molecular Biology, Nanophotonics and Nanomedicine. In this seminar, I will present a the precise, robust and high-yield assembly of gold nanoparticles on DNA origami templates. This enabled us to synthesize a self-assembled a plasmonic particle chain waveguide that was capable of an efficient energy propagation towards a nano diamond. Next, I will demonstrate a block copolymer-based strategy to protect DNA-based structures from nucleases and low salt conditions for nanomedical applications, and a "next-generation" DNA synthesis method to cost-effectively amplify oligonucleotides from oligonucleotide libraries. More information:

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