General Lab Information

Dale Kreitler

AMX Beamline Scientist, Structural Biology Program, National Synchrotron Light Source II

Dale Kreitler

Brookhaven National Laboratory

National Synchrotron Light Source II
Bldg. 745
P.O. Box 5000
Upton, NY 11973-5000

(631) 344-7318
dkreitler@bnl.gov

Expertise | Research | Education | Publications | Highlights


Expertise

  • Macromolecular crystallography
  • Peptide chemistry
  • Protein expression
  • Computer vision

Research Activities

  • Structural biology
  • Laboratory automation
  • Application of data science to macromolecular crystallography (MX) data
  • X-ray crystallographic fragment screening

Education

B.S. Chemistry/Chemical and Biomolecular Engineering, Johns Hopkins University

Ph.D. Chemistry, University of Wisconsin-Madison

Selected Publications

  • Rechkoblit O, Sciaky D, Kreitler DF, et al (2024) Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nature Structural & Molecular Biology 31:767–776. https://doi.org/10.1038/s41594-024-01220-x
  • Dong J, Yin Z, Kreitler D, et al (2024) Bragg Spot Finder (BSF): a new machine-learning-aided approach to deal with spot finding for rapidly filtering diffraction pattern images. Journal of Applied Crystallography 57:670–680. https://doi.org/10.1107/s1600576724002450
  • Yu Z, Kreitler DF, Chiu YTT, et al (2023) Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification. Angewandte Chemie 135:. https://doi.org/10.1002/ange.202308100
  • Alexander EM, Kreitler DF, Guidolin V, et al (2020) Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca. ACS Infectious Diseases 6:1976–1997. https://doi.org/10.1021/acsinfecdis.0c00326
  • Kreitler DF, Gemmell EM, Schaffer JE, et al (2019) The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase. Nature Communications 10:. https://doi.org/10.1038/s41467-019-11383-7
  • Kreitler DF, Yao Z, Steinkruger JD, et al (2019) A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation. Journal of the American Chemical Society 141:1583–1592. https://doi.org/10.1021/jacs.8b11246

Research Highlights

https://www.bnl.gov/newsroom/news.php?a=221721

https://source.washu.edu/2019/07/first-pictures-of-enzyme-that-drives-new-class-of-antibiotics/

Dale Kreitler

Brookhaven National Laboratory

National Synchrotron Light Source II
Bldg. 745
P.O. Box 5000
Upton, NY 11973-5000

(631) 344-7318
dkreitler@bnl.gov

Dale's Links