Dale Kreitler
AMX Beamline Scientist, Structural Biology Program, National Synchrotron Light Source II

Brookhaven National Laboratory
National Synchrotron Light Source II
Bldg. 745
P.O. Box 5000
Upton, NY 11973-5000
(631) 344-7318
dkreitler@bnl.gov
Expertise | Research | Education | Publications | Highlights
Expertise
- Macromolecular crystallography
- Peptide chemistry
- Protein expression
- Computer vision
Research Activities
- Structural biology
- Laboratory automation
- Application of data science to macromolecular crystallography (MX) data
- X-ray crystallographic fragment screening
Education
B.S. Chemistry/Chemical and Biomolecular Engineering, Johns Hopkins University
Ph.D. Chemistry, University of Wisconsin-Madison
Selected Publications
- Rechkoblit O, Sciaky D, Kreitler DF, et al (2024) Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nature Structural & Molecular Biology 31:767–776. https://doi.org/10.1038/s41594-024-01220-x
- Dong J, Yin Z, Kreitler D, et al (2024) Bragg Spot Finder (BSF): a new machine-learning-aided approach to deal with spot finding for rapidly filtering diffraction pattern images. Journal of Applied Crystallography 57:670–680. https://doi.org/10.1107/s1600576724002450
- Yu Z, Kreitler DF, Chiu YTT, et al (2023) Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification. Angewandte Chemie 135:. https://doi.org/10.1002/ange.202308100
- Alexander EM, Kreitler DF, Guidolin V, et al (2020) Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca. ACS Infectious Diseases 6:1976–1997. https://doi.org/10.1021/acsinfecdis.0c00326
- Kreitler DF, Gemmell EM, Schaffer JE, et al (2019) The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase. Nature Communications 10:. https://doi.org/10.1038/s41467-019-11383-7
- Kreitler DF, Yao Z, Steinkruger JD, et al (2019) A Hendecad Motif Is Preferred for Heterochiral Coiled-Coil Formation. Journal of the American Chemical Society 141:1583–1592. https://doi.org/10.1021/jacs.8b11246
Research Highlights
https://www.bnl.gov/newsroom/news.php?a=221721
https://source.washu.edu/2019/07/first-pictures-of-enzyme-that-drives-new-class-of-antibiotics/

Brookhaven National Laboratory
National Synchrotron Light Source II
Bldg. 745
P.O. Box 5000
Upton, NY 11973-5000
(631) 344-7318
dkreitler@bnl.gov