Martin Fuchs

Brookhaven National Laboratory

National Synchrotron Light Source II
Bldg. 745
P.O. Box 5000
Upton, NY 11973-5000

(631) 344-8890
mfuchs@bnl.gov

Research | Education | Appointments | Publications

Research Activities

Martin has been studying the structure and function of proteins and other biological macromolecules by developing experimental methods using microwaves, light, and X-rays. These methods include microfocus and serial crystallography with a new focus on time-resolved room temperature studies, optical spectroscopies to study biomimetic electron transfer systems, ultra-high-field electron spin resonance on membrane proteins and enzymes, and at times the combination of these, using concurrent optical spectroscopy and macromolecular crystallography to study the oxidation states of heme proteins and radiation damage in protein crystals.

Education

Ph.D. 1999:  Physics, Freie Universität Berlin, Germany
Diplom (~ M.S.) 1994:  Physics, Freie Universität Berlin, Germany
Vordiplom (~ B.S.) 1991:   Physics, Heidelberg University, Germany

Professional Appointments

2013-now     Beamline Scientist, Brookhaven National Lab / NSLS-II, Upton, NY, USA
2008-2013    Beamline Scientist, Paul Scherrer Institute / Swiss Light Source, Villigen, Switzerland
2007-2008    Beamline Scientist, Helmholtz Zentrum Berlin / BESSY, Berlin, Germany
2004-2007    Postdoc, Free University Berlin / BESSY, Berlin, Germany
2000-2004    Postdoc, Department of Physics, Free University Berlin, Berlin, Germany

Selected Publications

• Schneider DK, Shi W, Andi B, Jakoncic J, Gao Y, Bhogadi DK, Myers SF, Martins B, Skinner JM, Aishima J, Qian K, Bernstein HJ, Lazo EO, Langdon T, Lara J, Shea-McCarthy G, Idir M, Huang L, Chubar O, Sweet RM, Berman LE, McSweeney S, Fuchs MR (2021) FMX – the Frontier Microfocusing Macromolecular Crystallography Beamline at the National Synchrotron Light Source II. Journal of Synchrotron Radiation 28:650–665. doi: 10.1107/s1600577520016173
• Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, et al. (2021) Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science Advances 7:eabf8711. doi: 10.1126/sciadv.abf8711
• Guo G, Fuchs MR, Shi W, Skinner J, Berman E, Ogata CM, Hendrickson WA, McSweeney S, Liu Q (2018) Sample manipulation and data assembly for robust microcrystal synchrotron crystallography. IUCrJ 5:238–246. doi: 10.1107/s2052252518005389
• Gao Y, Xu W, Shi W, Soares A, Jakoncic J, Myers S, Martins B, Skinner J, Liu Q, Bernstein H, McSweeney S, Nazaretski E, Fuchs MR (2018) High-speed raster-scanning synchrotron serial microcrystallography with a high-precision piezo-scanner. Journal of Synchrotron Radiation 25:1362–1370. doi: 10.1107/s1600577518010354
• Owen RL, Juanhuix J, Fuchs M (2016) Current advances in synchrotron radiation instrumentation for MX experiments. Archives of Biochemistry and Biophysics 602:21–31. doi: 10.1016/j.abb.2016.03.021
• Fuchs MR, Pradervand C, Thominet V, Schneider R, Panepucci E, Grunder M, Gabadinho J, Dworkowski FSN, Tomizaki T, Schneider J, Mayer A, Curtin A, Olieric V, Frommherz U, Kotrle G, Welte J, Wang X, Maag S, Schulze-Briese C, Wang M (2014) D3, the new diffractometer for the macromolecular crystallography beamlines of the Swiss Light Source. Journal of Synchrotron Radiation 21:340–351. doi: 10.1107/s160057751400006x
• Merlino A, Fuchs MR, Pica A, Balsamo A, Dworkowski FSN, Pompidor G, Mazzarella L, Vergara A (2012) Selective X-ray-induced NO photodissociation in haemoglobin crystals: evidence from a Raman-assisted crystallographic study. Acta Crystallographica Section D Biological Crystallography 69:137–140. doi: 10.1107/s0907444912042229
• Pompidor G, Dworkowski FSN, Thominet V, Schulze-Briese C, Fuchs MR (2013) A new on-axis micro-spectrophotometer for combining Raman, fluorescence and UV/Vis absorption spectroscopy with macromolecular crystallography at the Swiss Light Source. Journal of Synchrotron Radiation 20:765–776. doi: 10.1107/s0909049513016063
• Fuchs MR, Schleicher E, Schnegg A, Kay CWM, Törring JT, Bittl R, Bacher A, Richter G, Möbius K, Weber S (2002) g-Tensor of the Neutral Flavin Radical Cofactor of DNA Photolyase Revealed by 360-GHz Electron Paramagnetic Resonance Spectroscopy. The Journal of Physical Chemistry B 106:8885–8890. doi: 10.1021/jp0259869
• Fuchs MR, Prisner TF, Möbius K (1999) A high-field/high-frequency heterodyne induction-mode electron paramagnetic resonance spectrometer operating at 360 GHz. Review of Scientific Instruments 70:3681–3683. doi: 10.1063/1.1149977