cryo-EM Course at the Laboratory for BioMolecular Structure (LBMS)

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Motivation

The Laboratory for BioMolecular Structure (LBMS) at Brookhaven National Laboratory aims to organize, support, and grow the cryo-EM community for researchers funded by the U.S. Department of Energy (DOE). This annual virtual cryo-EM course introduces the technique to researchers working in DOE mission-relevant fields, equipping them with the knowledge to begin using this powerful and versatile technique.

By doing so, the course helps advance our understanding of the biological complexity of plant and microbial metabolism, from the molecular level to entire ecosystems. Additionally, it supports the development of technologies to identify and engineer DOE mission-relevant metabolic capabilities in bacteria, fungi, archaea, viruses, plants, and mixed microbial communities.

Registration

This cryo-EM Course is open to the public. To be eligible to attend, all participants must register online by June 11, 2026. For questions or assistance with registering, please contact the Course Coordinator.

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Course Topics

Introduction to LBMS
Introduction to electron microscopy and structural biology
Introduction to electron microscope and image formation process
Introduction to negative staining and cryo-electron microscopy
Single-particle sample preparation tutorial and demonstration (negative staining and cryogenic vitrification)
Single particle reconstruction: theory, application and available software
MicroED: theory, application and available software

Cryo-electron tomography
EPU single particle data collection tutorial and demonstration
Model building, refinement, and validation.
Cryo-FIB sample preparation tutorial and demonstration
SerialEM electron tomography data collection tutorial and demonstration
Single-particle data analysis workflow tutorial and demonstration
Tomographic data analysis workflow including subtomography average tutorial and demonstration.
Applications of Artificial Intelligence (AI)

Committee Information

Liguo Wang
LBMS at Brookhaven National Laboratory
Guobin Hu: LBMS at Brookhaven National Laboratory
Jake Kaminsky: LBMS at Brookhaven National Laboratory
Qun Liu: Biology Department at Brookhaven National Laboratory
Yong Xiong: Professor, Dept. of Molecular Biophysics and Biochemistry, Yale University
Dongyan Tan: Assistant Professor, Pharmacological Sciences, Stony Brook University
Jun Liu: Professor, Department of Microbial Pathogenesis, Yale University
Sean McSweeney: NSLS-II at Brookhaven National Laboratory

Past Events

View information from previous events.

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Invited Speakers

Bronwyn Lucas (Berkeley)
Chen Xu (Umass)
Dongyan Tan (SBU)
Ellen Zhong (Princeton)
Eric Gouaux (OHSU)
Fred Sigworth (Yale)
Grant Jensen (BYU)
Jake Kaminsky (BNL)
Jianlin Cheng (U Missouri)
Liguo Wang (BNL)
Matt Swulius (Penn State)
Mike Martynowycz (HWI)
Momoko Shiozaki
Muyuan Chen (Stanford)
Oliver Clarke (Columbia)
Phil Guo (McGill)
Sean McSweeney (BNL)

Important Dates

April 29, 2026	General registration opens
June 11, 2026	General registration closes

Course Information

Note: This event falls under Exemption D (Formal classroom training held at Federal facilities, which does not exhibit indicia of a formal conference as outlined in the Conference/Event Exemption Request Form.)