Diane Cabelli

Brookhaven National Laboratory

Chemistry Division
Bldg. 555A, Room 170
P.O. Box 5000
Upton, NY 11973-5000

(631) 344-4361
cabelli@bnl.gov

Preferred Gender Pronouns (PGPs): She, her

Research | Education | Appointments | Publications | Highlights | Awards

Research Activities

Electron- and Photo-Induced Processes for Molecular Energy Conversion

Kinetics and mechanisms of high valent metal complex reactivity in water; oxygen radical reactivity with enzymes/cellular components (superoxide dismutases/reductases)

Education

A.B, Bryn Mawr College
Ph.D., University of Texas at Austin (1979, w/ Michael Dewar/Alan Cowley)

Professional Appointments

National Museum Act Fellowship, Conservation Center, Institute of Fine Arts, New York University 1980-1981
Research Associate, Brookhaven National Laboratory,1981-1983
Assistant Chemist, Brookhaven National Laboratory,1983-1987
Visiting Scientist, Risoe National Laboratory, Denmark, 1985-1986
Associate Chemist, Brookhaven National Laboratory, 1988-1995
Chemist, Brookhaven National Laboratory, 1995-present

Selected Publications

• Cabelli DE (2018) Redox activity goes organic. Nature Chemistry 10:1173–1175. doi: 10.1038/s41557-018-0180-y
• Barnese K, Gralla EB, Cabelli DE, Selverstone Valentine J (2008) Manganous Phosphate Acts as a Superoxide Dismutase. Journal of the American Chemical Society 130:4604–4606. doi: 10.1021/ja710162n

Research Highlights

Selected Recent Publications

• Ryan, K.C., Guce, A.I., Johnson, O.E., Brunold, T.C., Cabelli, D.E., Garman, S.C., Maroney, M.J. (accepted) “Nickel Superoxide Dismutase: Structural and Functional Roles of His1 and its H-bonding Network” Biochem.
• Dassanayake, R.S., Cabelli, D.E., Brasch, N.E.  (accepted) “Pulse Radiolysis Studies on the Reactions of Carbonate Radical with Vitamin B12 Complexes: Evidence for the destruction of the corrin ring” Chem.-A Europ. J.
• Sohn, S.H.; Sea, K.; Durazo, A.; Sheng, Y.; Shaw, B.; Cao, X; Hart, P.J.; Cabelli, D.E.; Gralla, E.B.; Valentine, J.S. (in press) “Intrasubunit Disulfide Bond Is Not Essential for the Activity of Copper-Zinc Superoxide Dismutase” J Biol. Chem.
• Pinto, AF,; Romão, CV; Pinto, LC; Huber, H.; Saraiva, LM; Todorovic, S.; Cabelli, DE; Teixeira, M. 2015 “Superoxide reduction by a  superoxide reductase lacking the highly conserved lysine residue.” J. BioInorg. Chem. 20 155-164
• Dassanayake, R.S., Cabelli, D.E., Brasch, N.E.  2015 “Pulse Radiolysis Studies of the Reaction of Nitrogen Dioxide with the Vitamin B12 Complexes Cob(II)alamin and Nitrocobalamin” J. Inorg. Biochem. 142 54-58
• Gleason, J.E., Galaleldeen, A., Peterson, R.L., Taylor, A.B., Holloway, S.P., Waninger-Saroni, J., Cormack, B., Cabelli, D.E., Hart, P.J., Culotta, V.C. 2014 “Candida albicans SOD5 represents the prototype of a new class of copper only superoxide dismutase enzymes required for pathogen defense.” Proc. Nat. Acad. Sci. 111 5866-5871.
• Cabelli D. 2014 “Probing Superoxide Dismutases through Radiation Chemistry” Isr. J. Chem. 54 272-278
• Sheng, Y.; Abreu, I.A.; Cabelli, D.E.; Maroney, M.J.; Miller, A-F.; Teixeira, M.; Valentine, J.S. 2014 “ Superoxide Dismutases and Superoxide Reductases. Chem. Rev. 114 3854-3918.
• Dassanayake, R.S., Cabelli, D.E., Brasch, N.E. 2013 “Pulse Radiolysis Studies on the Reaction of the Reduced Vitamin B12 Complex Cob(II)alamin with Superoxide” ChemBioChem 14 1081-3.
• Sheng, Y.; Durazo, A.; Schumacher, M.; Gralla, E.B.; Cascio, D.; Cabelli, D.E.; Valentine, J.S. 2013 “Tetramerization in Yeast MnSOD and its Functional Significance”  PLOS One 8(5) e62446.
• Schneider J.; Jia, H.; Kobiro, K.; Cabelli, D.; Muckerman, J.T.; Fujita, E. 2012 “Nickel(II) Macrocycles: Highly Efficient Electrocatalysts for the Selective Reduction of CO₂ to CO” Energy Env. Sci. 5 9502-9510.
• Sheng, Y.; Gralla, E.B.; Schumacher, M.; Cascio, D.; Cabelli, D.E.; Valentine, J.S. 2012 “Six-coordinate manganese(3+) in catalysis by yeast” Proc. Nat. Acac. Sci. 109 14314-14319.
• Barnese, K.; Gralla, E.; Cabelli, D.E.; Valentine, J.S. 2012 “ Biologically Relevant Mechanism For Catalytic Removal of Superoxide by Simple Manganese Compounds” Proc. Nat. Acad. Sci. 109 6892-6897.
• Cohen, B.W.; Polyansky, D.E.: Achord, P.; Cabelli, D.E.; Muckerman, J.T.; Tanaka, K.; Thummel, R.P.; Zong, R.; Fujita, E. 2012 “Steric Effects for Hydride, Hydrogen Atom and Proton Transfer Reactions with Geometric Isomers of NADH-Model Ruthenium Complexes” Faraday Discussions 155 129-144.
• Cabelli, D.E. 2012 “Superoxide Dismutases and Reactive Oxygen Species” in Principles of Free Radical Biomedicine, Vol 2, Pantopolous, K. and Schipper, H. eds. Nova Science Pub. Inc., New York. Pp. 81-99.

Awards & Recognition

Brookhaven Town Woman's Recognition Award in Science 2003