Denis Leshchev
ISS Beamline Scientist, Hard X-ray Scattering & Spectroscopy Program, National Synchrotron Light Source II
Brookhaven National Laboratory
National Synchrotron Light Source II
Bldg. 743, Room 153
P.O. Box 5000
Upton, NY 11973-5000
(631) 344-7326
dleshchev@bnl.gov
Preferred Gender Pronouns (PGPs): he, him
I work as an Assistant Physicist in the Photon Sciences division and primarily function as a Beamline Scientist for the Inner Shell Spectroscopy (ISS) 08-ID beamline of NSLS-II. I support the user operations of the beamline and development of hardware and software capabilities. Additionally, I develop advanced spectroscopy program at ISS, focusing on delivering high-resolution X-ray absorption and X-ray emission spectroscopic capabilities to the user community.
Research | Education | Appointments | Publications
Research Activities
I believe that seeing things in action is the best approach to understanding of how the universe works. Hence, my work focuses on understanding dynamic phenomena in a wide variety of systems, ranging from small molecules and nanomaterials to proteins and synthetic macromolecules. Often, the function of materials relies on a network of interactions spanning multiple scales in time and space, requiring characterization from multiple points of view. To achieve that goal and develop mechanistic models of the events happening on the molecular level, I appoach the scientific problems using my expertise in scattering and spectroscpic tools, advanced data analyitcs, and instrumentation development.
Education
- PhD (Physics), Universite Grenoble Alpes (Grenoble, France)
- MSc (Physics and Engineering), National Research Nuclear University (Moscow, Russia)
Professional Appointments
2020-now - Assistant Physicist at NSLS-II (Upton, NY, USA)
2016-2020 - Postdoc with prof. Lin X Chen at Northwestern University (Evanston, IL, USA)
2016 - Junior Scientist at European Synchrotron Radiation Facility (Grenoble, France)
Selected Publications
- Leshchev D, Harlang TCB, Fredin LA, Khakhulin D, Liu Y, Biasin E, Laursen MG, Newby GE, Haldrup K, Nielsen MM, Wärnmark K, Sundström V, Persson P, Kjær KS, Wulff M (2018) Tracking the picosecond deactivation dynamics of a photoexcited iron carbene complex by time-resolved X-ray scattering. Chemical Science 9:405–414. doi: 10.1039/c7sc02815f
- Rimmerman D, Leshchev D, Hsu DJ, Hong J, Kosheleva I, Chen LX (2017) Direct Observation of Insulin Association Dynamics with Time-Resolved X-ray Scattering. The Journal of Physical Chemistry Letters 8:4413–4418. doi: 10.1021/acs.jpclett.7b01720
- Hsu DJ, Leshchev D, Rimmerman D, Hong J, Kelley MS, Kosheleva I, Zhang X, Chen LX (2019) X-ray snapshots reveal conformational influence on active site ligation during metalloprotein folding. Chemical Science 10:9788–9800. doi: 10.1039/c9sc02630d
Brookhaven National Laboratory
National Synchrotron Light Source II
Bldg. 743, Room 153
P.O. Box 5000
Upton, NY 11973-5000
(631) 344-7326
dleshchev@bnl.gov
