Guobin Hu
Laboratory for Biomolecular Structure, National Synchrotron Light Source II
Brookhaven National Laboratory
National Synchrotron Light Source II
Bldg. 745
P.O. Box 5000
Upton, NY 11973-5000
(631) 344-7915
ghu@bnl.gov
Dr. Guobin Hu transitioned to the field of Cryo-EM after he obtained his Ph.D. in physics. He has been leading the daily operation, user training and user support at LBMS. In addition to several collaborative user research projects, he has also been developing his own independent research. His personal research focuses on cellular structures and dynamics by Cryo-EM/ET.
Expertise | Education | Publications | Highlights
Expertise
Cryo-EM
Cryo-ET
Education
Ph.D. in physics
Selected Publications
- Zuo H, Park J, Frangaj A, et al (2024) Promiscuous G-protein activation by the calcium-sensing receptor. Nature 629:481–488. https://doi.org/10.1038/s41586-024-07331-1
- Chaya T, Banerjee A, Rutter BD, et al (2023) The extracellular vesicle proteomes of Sorghum bicolor and Arabidopsis thaliana are partially conserved. Plant Physiology 194:1481–1497. https://doi.org/10.1093/plphys/kiad644
- Hu G-B (2014) Whole Cell Cryo-Electron Tomography Suggests Mitochondria Divide by Budding. Microscopy and Microanalysis 20:1180–1187. https://doi.org/10.1017/s1431927614001317
- Leo-Macias A, Katz G, Wei H, et al (2011) Toroidal surface complexes of bacteriophage ?12 are responsible for host-cell attachment. Virology 414:103–109. https://doi.org/10.1016/j.virol.2011.03.020
- Li G, Margueron R, Hu G, et al (2010) Highly Compacted Chromatin Formed In Vitro Reflects the Dynamics of Transcription Activation In Vivo. Molecular Cell 38:41–53. https://doi.org/10.1016/j.molcel.2010.01.042
- Hu G-B, Wei H, Rice WJ, et al (2008) Electron cryo-tomographic structure of cystovirus ?12. Virology 372:1–9. https://doi.org/10.1016/j.virol.2007.10.013
- Hu G-B, Rice WJ, Dröse S, et al (2008) Three-dimensional structure of the KdpFABC complex of Escherichia coli by electron tomography of two-dimensional crystals. Journal of Structural Biology 161:411–418. https://doi.org/10.1016/j.jsb.2007.09.006
- Hu GB, Peng L-M, Yu QF, Lu HQ (2000) Automated identification of symmetry in CBED patterns: a genetic approach. Ultramicroscopy 84:47–56. https://doi.org/10.1016/s0304-3991(00)00006-1
- Hu JZ, Qiao L, Zhao X, et al (2025) Continuity of Mitochondrial Budding: Insights from BS-C-1 Cells by In Situ Cryo-electron Tomography. Microscopy and Microanalysis. https://doi.org/10.1093/mam/ozae122
Research Highlights
Empowered by the cutting-edge Cryo-ET, Dr. Guobin Hu discovered mitochondrial budding and hypothsized that mitochondria reproduce through budding, contrast to the prevailing hypothesis of Drp1-mediated mitochondrial binary fission.
Brookhaven National Laboratory
National Synchrotron Light Source II
Bldg. 745
P.O. Box 5000
Upton, NY 11973-5000
(631) 344-7915
ghu@bnl.gov
