Guobin Hu

Brookhaven National Laboratory

National Synchrotron Light Source II
Bldg. 745
P.O. Box 5000
Upton, NY 11973-5000

(631) 344-7915
ghu@bnl.gov

Expertise | Education | Publications | Highlights

Expertise

Cryo-EM

Cryo-ET

Education

Ph.D. in physics

Selected Publications

• Zuo H, Park J, Frangaj A, et al (2024) Promiscuous G-protein activation by the calcium-sensing receptor. Nature 629:481–488. https://doi.org/10.1038/s41586-024-07331-1
• Chaya T, Banerjee A, Rutter BD, et al (2023) The extracellular vesicle proteomes of Sorghum bicolor and Arabidopsis thaliana are partially conserved. Plant Physiology 194:1481–1497. https://doi.org/10.1093/plphys/kiad644
• Hu G-B (2014) Whole Cell Cryo-Electron Tomography Suggests Mitochondria Divide by Budding. Microscopy and Microanalysis 20:1180–1187. https://doi.org/10.1017/s1431927614001317
• Leo-Macias A, Katz G, Wei H, et al (2011) Toroidal surface complexes of bacteriophage ?12 are responsible for host-cell attachment. Virology 414:103–109. https://doi.org/10.1016/j.virol.2011.03.020
• Li G, Margueron R, Hu G, et al (2010) Highly Compacted Chromatin Formed In Vitro Reflects the Dynamics of Transcription Activation In Vivo. Molecular Cell 38:41–53. https://doi.org/10.1016/j.molcel.2010.01.042
• Hu G-B, Wei H, Rice WJ, et al (2008) Electron cryo-tomographic structure of cystovirus ?12. Virology 372:1–9. https://doi.org/10.1016/j.virol.2007.10.013
• Hu G-B, Rice WJ, Dröse S, et al (2008) Three-dimensional structure of the KdpFABC complex of Escherichia coli by electron tomography of two-dimensional crystals. Journal of Structural Biology 161:411–418. https://doi.org/10.1016/j.jsb.2007.09.006
• Hu GB, Peng L-M, Yu QF, Lu HQ (2000) Automated identification of symmetry in CBED patterns: a genetic approach. Ultramicroscopy 84:47–56. https://doi.org/10.1016/s0304-3991(00)00006-1
• Hu JZ, Qiao L, Zhao X, et al (2025) Continuity of Mitochondrial Budding: Insights from BS-C-1 Cells by In Situ Cryo-electron Tomography. Microscopy and Microanalysis. https://doi.org/10.1093/mam/ozae122

Research Highlights

Empowered by the cutting-edge Cryo-ET, Dr. Guobin Hu discovered mitochondrial budding and hypothsized that mitochondria reproduce through budding, contrast to the prevailing hypothesis of Drp1-mediated mitochondrial binary fission. A paper published in Microscopy and Microanalysis in 2025 was selected as Highlight from Microscopy and Microanalysis by Microscopy Today.