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Yang Yang

Physicist & QCT Lead Beamline Scientist, Biological, Environmental, and Planetary Sciences Division, National Synchrotron Light Source II

Brookhaven National Laboratory

National Synchrotron Light Source II
Bldg. 745, Room 103
P.O. Box 5000
Upton, NY 11973-5000

(631) 344-6309
(631) 344-6309
yyang@bnl.gov

Yang Yang is the QCT Lead Beamline Scientist at the National Synchrotron Light Source II (NSLS-II) at Brookhaven National Laboratory. She leads the development of the Quantitative Cellular Tomography (QCT) beamline, an upcoming cryo-soft X-ray tomography capability for three-dimensional imaging of frozen-hydrated intact cells.

QCT will combine nanoscale cellular tomography with correlative cryo-light microscopy to connect subcellular structure with biological function. Yang’s research focuses on quantitative and multimodal X-ray imaging for cell biology, microbial and environmental systems, and cryogenic biological sample workflows. She welcomes inquiries from prospective users and collaborators interested in cryo-soft X-ray tomography, correlative imaging, and cellular nanoimaging.

Expertise | Education | Appointments | Publications | Highlights

Expertise

Cryo-soft X-ray tomography and three-dimensional cellular imaging
X-ray nanoimaging, phase-contrast tomography, and X-ray fluorescence microscopy
Correlative cryo-light and X-ray imaging
Imaging and quantitative analysis of frozen-hydrated cells
Multimodal and multiscale imaging workflows
Cryogenic biological sample preparation and imaging

Education

Ph.D in Chemistry, Freiburg University, Germany.

B.Sc. in Applied Physics, Xidian Univeristy, China.

Professional Appointments

2024 - Present QCT Lead Beamline Scientist, Brookhaven National Laboartory

2019 - 2024 SRX beamline scientist, NSLS-II, Brookhaven National Laboratory

2017 - 2018 Junior beamline scientist, ID16A, ESRF, France

2014 - 2017 Postdoctoral researcher, ID16A, ESRF, France

Selected Publications

Lin Z, Zhang X, Nandi P, et al (2024) Correlative single-cell hard X-ray computed tomography and X-ray fluorescence imaging
Gramaccioni C, Yang Y, Procopio A, et al (2018) Nanoscale quantification of intracellular element concentration by X-ray fluorescence microscopy combined with X-ray phase contrast nanotomography. Applied Physics Letters 112:. https://doi.org/10.1063/1.5008834
Yang Y, Fus F, Pacureanu A, da Silva JC, De Nolf W, Biot C, Bohic S, Cloetens P (2019) Three-Dimensional Correlative Imaging of a Malaria-Infected Cell with a Hard X-ray Nanoprobe. Analytical Chemistry. doi: 10.1021/acs.analchem.8b05957
Conesa JJ, Carrasco AC, Rodríguez-Fanjul V, Yang Y, Carrascosa JL, Cloetens P, Pereiro E, Pizarro AM (2019) Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X-Ray Imaging. Angewandte Chemie International Edition 59:1270–1278. doi: 10.1002/anie.201911510
Kapishnikov S, Staalsø T, Yang Y, Lee J, Pérez-Berná AJ, Pereiro E, Yang Y, Werner S, Guttmann P, Leiserowitz L, Als-Nielsen J (2019) Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo. Proceedings of the National Academy of Sciences 116:22946–22952. doi: 10.1073/pnas.1910123116
Gramaccioni C, Yang Y, Pacureanu A, Vigano N, Procopio A, Valenti P, Rosa L, Berlutti F, Bohic S, Cloetens P (2020) Cryo-nanoimaging of Single Human Macrophage Cells: 3D Structural and Chemical Quantification. Analytical Chemistry 92:4814–4819. doi: 10.1021/acs.analchem.9b04096