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Yang Yang

QCT Lead Beamline Scientist, Biological, Environmental, and Planetary Sciences Division, National Synchrotron Light Source II

Brookhaven National Laboratory

National Synchrotron Light Source II
Bldg. 745, Room 103
P.O. Box 5000
Upton, NY 11973-5000

(631) 344-6309
(631) 344-6309
yyang@bnl.gov

Yang is an X-ray nano-imaging scientist with expertise in 2D and 3D X-ray nano-imaging with sycnhrotron-based techniques. She has worked in Sub-micron Resolution Microscopy (SRX) beamline using scanning X-ray fluorescence microscopy and spectroscopic imaging on a wide range of applications. She is now the lead beamline scientist in Quantitative Cellular Tomography (QCT) beamline, a soft X-ray nano-tomography dedicated to 3D imaging of frozen hydrated intact cells. Ppart of NEXT-III project in NSLS-II, the beamline iscurrently under deisgn phase, and is expected to be finished in 2029.

Expertise | Education | Appointments | Publications | Highlights

Expertise

Yang has more than 12 years experience in 2D and 3D X-ray nano-imaging, especially with bio-imaging techniques and related bio-sample preparation. She also has extensive experiences with multi-scale and multi-modal imaging. She implemented correlative imaging and phase contrast imaging to reveal the sub-cellular structural and indogeneous elemental information on frozen hydrated cells without sectioning and labeling.

Education

Ph.D in Chemistry, Freiburg University, Germany.

B.Sc. in Applied Physics, Xidian Univeristy, China.

Professional Appointments

2021-present Associate Physicist, NSLS-II, Brookhaven National Laboratory, USA

2019-2021 Assistant Physicist, NSLS-II, Brookhaven National Laboratory, USA

2017-2018 Junior beamline scientist, ID16A, ESRF, France

2014-2017 Postdoctoral researcher, ID16A, ESRF, France

Selected Publications

Gramaccioni C, Yang Y, Pacureanu A, Vigano N, Procopio A, Valenti P, Rosa L, Berlutti F, Bohic S, Cloetens P (2020) Cryo-nanoimaging of Single Human Macrophage Cells: 3D Structural and Chemical Quantification. Analytical Chemistry 92:4814–4819. doi: 10.1021/acs.analchem.9b04096
Conesa JJ, Carrasco AC, Rodríguez-Fanjul V, Yang Y, Carrascosa JL, Cloetens P, Pereiro E, Pizarro AM (2019) Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X-Ray Imaging. Angewandte Chemie International Edition 59:1270–1278. doi: 10.1002/anie.201911510
Yang Y, Fus F, Pacureanu A, da Silva JC, De Nolf W, Biot C, Bohic S, Cloetens P (2019) Three-Dimensional Correlative Imaging of a Malaria-Infected Cell with a Hard X-ray Nanoprobe. Analytical Chemistry. doi: 10.1021/acs.analchem.8b05957
Yang Y, Xu R, Zhang K, Lee S, Mu L, Liu P, Waters CK, Spence S, Xu Z, Wei C, Kautz DJ, Yuan Q, Dong Y, Yu Y, Xiao X, Lee H, Pianetta P, Cloetens P, Lee J, Zhao K, Lin F, Liu Y (2019) Quantification of Heterogeneous Degradation in Li-Ion Batteries. Advanced Energy Materials 9:1900674. doi: 10.1002/aenm.201900674
Cesar da Silva J, Pacureanu A, Yang Y, Bohic S, Morawe C, Barrett R, Cloetens P (2017) Efficient concentration of high-energy x-rays for diffraction-limited imaging resolution. Optica 4:492. doi: 10.1364/optica.4.000492
Kapishnikov S, Staalsø T, Yang Y, Lee J, Pérez-Berná AJ, Pereiro E, Yang Y, Werner S, Guttmann P, Leiserowitz L, Als-Nielsen J (2019) Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo. Proceedings of the National Academy of Sciences 116:22946–22952. doi: 10.1073/pnas.1910123116
Lin Z, Zhang X, Nandi P, et al (2024) Correlative single-cell hard X-ray computed tomography and X-ray fluorescence imaging
Gramaccioni C, Yang Y, Procopio A, et al (2018) Nanoscale quantification of intracellular element concentration by X-ray fluorescence microscopy combined with X-ray phase contrast nanotomography. Applied Physics Letters 112:. https://doi.org/10.1063/1.5008834