Technologies Available for License

2019-011- Peptoids for Stabilizing Coatings for Biomaterials

Invention: 2019-016

Patent Status: U.S. Patent Number 11,739,162 was issued on August 29, 2023

For technical and licensing related questions, email tcp@bnl.gov.

Summary

DNA nanotechnology, in particular, DNA origami structures could be beneficial for biomedical applications, including biosensing, in vivo imaging, and drug and gene delivery. However, protecting DNA origami structures in complex biological fluids while preserving their structural characteristics remains a major challenge for enabling these applications. Researchers have shown that octahedral DNA origamis coated with peptoid can be used as carriers for anticancer drug and protein, where the peptoid modulates the rate of drug release and protein stability against proteolytic hydrolysis. As an example, the researchers have used two alkyne-modified peptoids, conjugated with fluorophore and antibody, to make stable DNA origamis for imaging and cell-targeting. The results from the example demonstrate an approach toward functional and physiologically stable DNA origami for biomedical applications.

Description

The technology describes three peptoid formulations that could be used to coat DNA origamis that are designed to serve as vehicles to carry biomolecules to make them physiologically stable.

Journal Publication & Intellectual Property

• DNA origami protection and molecular interfacing through engineered sequence-defined peptoids (.pdf)
• US 11,739,162 B2 (.pdf)