Technologies Available for License

2024-005: Amplifying Biomolecule Detection Sensitivity Through Acoustic Wave

Invention: 2024-005

Patent Status: Non-Provisional filed on November 5, 2025

For technical and licensing related questions, email tcp@bnl.gov.

Summary

Researchers from BNL and Columbia University are developing a biosensing technology that enhances the sensitivity of nanoparticle-based rapid diagnostics by over 100-fold through using of acoustically driven non-equilibrium bioreactions.

Description

The detection method uses precisely shaped acoustic waves to accelerate molecular recognition, the core mechanism behind biosensing. These tailored acoustic pulses create localized, high-density zones of biofunctionalized nanoparticles, triggering faster and more effective binding with target biomolecules even at ultra-low concentrations. This invention allows for the detection of analytes at concentrations that were not possible without the use of acoustic energy.