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Laboratory for Biomolecular Structure

LBMS Publications

Publications are an important way to disseminate the breadth and depth of research performed at the Laboratory for BioMolecular Structure (LBMS). The LBMS Publications Database is the official source for listing all journal articles, conference proceedings, dissertations, books, technical reports, patents, and any other published work that used LBMS and/or LBMS resources. Users are expected to report their publications to the facility and this information is carefully considered during the proposal review process.

Facility Acknowledgement

All users are obligated to inform the Brookhaven National Laboratory of their publications or Ph.D. thesis based on research carried out, in whole or in part, at LBMS.

Use the following acknowledgment when referencing work done at LBMS.

The Laboratory for BioMolecular Structure (LBMS) is supported by the DOE Office of Biological and Environmental Research (KP1607011).

If you have a question about the publications database, or need assistance with a database related matter, please email


*High-impact papers are published in journals with an impact factor greater than 7. Citation counts are provided by Web of Science.

High ImpactHao Zuo, Jinseo Park, Aurel Frangaj, Jianxiang Ye, Guanqi Lu, Jamie J. Manning, Wesley B. Asher, Zhengyuan Lu, Guo-bin Hu, Liguo Wang, Joshua Mendez, Edward Eng, Zhening Zhang, Xin Lin, Robert Grassucci, Wayne A. Hendrickson, Oliver B. Clarke, Jonathan A. Javitch, Arthur D. Conigrave, Qing R. Fan, Promiscuous G-protein activation by the calcium-sensing receptor. Nature (2024). [doi: 10.1038/s41586-024-07331-1]

High ImpactGregory Zilberg, Alexandra K. Parpounas, Audrey L. Warren, Bianca Fiorillo, Davide Provasi, Marta Filizola, Daniel Wacker, Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT 1e R and 5-HT 1F R. Sci. Adv., 10(16) (2024). [doi: 10.1126/sciadv.adk4855]

Liguo Wang, Christina M. Zimanyi, Cryo-EM sample preparation for high-resolution structure studies. Acta Cryst Sect F, 80(4) (2024). [doi: 10.1107/S2053230X24002553]

Ping Ren, Yingxia Hu, Lei Peng, Luojia Yang, Kazushi Suzuki, Zhenhao Fang, Meizhu Bai, Liqun Zhou, Yanzhi Feng, Yongji Zou, Yong Xiong, Sidi Chen, Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages. Sig Transduct Target Ther, 8(1), 281 (2023). [doi: 10.1038/s41392-023-01509-1]

High ImpactMohammad Afsar, GuanQun Liu, Lijia Jia, Eliza A. Ruben, Digant Nayak, Zuberwasim Sayyad, Priscila dos Santos Bury, Kristin E. Cano, Anindita Nayak, Xiang Ru Zhao, Ankita Shukla, Patrick Sung, Elizabeth V. Wasmuth, Michaela U. Gack, Shaun K. Olsen, Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat. Comm., 14(1), 4786 (2023). [doi: 10.1038/s41467-023-39780-z]

Preeti Verma, Albert L. Kwansa, Ruoya Ho, Yaroslava G. Yingling, Jochen Zimmer, Insights into substrate coordination and glycosyl transfer of poplar cellulose synthase-8. Structure, 31(10), 1166-1173.e6 (2023). [doi: 10.1016/j.str.2023.07.010]

High ImpactJacob W. Weaver, Sergey Proshkin, Wenqian Duan, Vitaly Epshtein, Manjunath Gowder, Binod K. Bharati, Elena Afanaseva, Alexander Mironov, Alexander Serganov, Evgeny Nudler, Control of transcription elongation and DNA repair by alarmone ppGpp. Nat Struct Mol Biol, 30(5), 600-607 (2023). [doi: 10.1038/s41594-023-00948-2]

High ImpactLie Wang, Anthony Hoang, Eva Gil-Iturbe, Arthur Laganowsky, Matthias Quick, Ming Zhou, Mechanism of anion exchange and small-molecule inhibition of pendrin. Nat. Comm., 15(1), 346 (2024). [doi: 10.1038/s41467-023-44612-1]

Liguo Wang, Xi Yang, Monte Carlo Simulation of Electron Interactions in an MeV-STEM for Thick Frozen Biological Sample Imaging. Applied Sciences, 14(5), 1888 (2024). [doi: 10.3390/app14051888]

High ImpactChunyi Hu, Mason T. Myers, Xufei Zhou, Zhonggang Hou, Macy L. Lozen, Ki Hyun Nam, Yan Zhang, Ailong Ke, Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol. Cell, 84(3), 463-475.e5 (2024). [doi: 10.1016/j.molcel.2023.12.034]

Gaya P. Yadav, Haiyuan Wang, Joke Ouwendijk, Stephen Cross, Qiaochu Wang, Feng Qin, Paul Verkade, Michael X. Zhu, Qiu-Xing Jiang, Chromogranin B (CHGB) is dimorphic and responsible for dominant anion channels delivered to cell surface via regulated secretion. Front. Mol. Neurosci., 16 (2023). [doi: 10.3389/fnmol.2023.1205516]

High ImpactMinfei Su, Jinan Wang, Guoqing Xiang, Hung Nguyen Do, Joshua Levitz, Yinglong Miao, Xin-Yun Huang, Structural basis of agonist specificity of α1A-adrenergic receptor. Nat. Comm., 14(1), 4819 (2023). [doi: 10.1038/s41467-023-40524-2]

High ImpactSwapnil C. Devarkar, Michael Vetick, Shravani Balaji, Ivan B. Lomakin, Luojia Yang, Danni Jin, Wendy V. Gilbert, Sidi Chen, Yong Xiong, Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses. Cell Rep., 42(10), 113156 (2023). [doi: 10.1016/j.celrep.2023.113156]

Christopher J. Gisriel, Gaozhong Shen, Gary W. Brudvig, Donald A. Bryant, Structure of the antenna complex expressed during far-red light photoacclimation in Synechococcus sp. PCC 7335. J. Biol. Chem., 300(2), 105590 (2024). [doi: 10.1016/j.jbc.2023.105590]

High ImpactTimothy Chaya, Aparajita Banerjee, Brian D Rutter, Deji Adekanye, Jean Ross, Guobin Hu, Roger W Innes, Jeffrey L Caplan, The extracellular vesicle proteomes of <em>Sorghum bicolor</em> and <em>Arabidopsis thaliana</em> are partially conserved. Plant Physiol. (2024). [doi: 10.1093/plphys/kiad644]

High ImpactAnuska Das, Jay Rai, Mitchell O. Roth, Yuerong Shu, Megan L. Medina, Mackenzie R. Barakat, Hong Li, Coupled catalytic states and the role of metal coordination in Cas9. Nat. Catal., 6(10), 969-977 (2023). [doi: 10.1038/s41929-023-01031-1]

High ImpactYu Zhao, Jay Rai, Hong Li, Regulation of translation by ribosomal RNA pseudouridylation. Sci. Adv., 9(33) (2023). [doi: 10.1126/sciadv.adg8190]

High ImpactMichael J. Capper, Shifan Yang, Alexander C. Stone, Sezen Vatansever, Gregory Zilberg, Yamuna Kalyani Mathiharan, Raul Habib, Keino Hutchinson, Yihan Zhao, Avner Schlessinger, Mihaly Mezei, Roman Osman, Bin Zhang, Daniel Wacker, Substrate binding and inhibition of the anion exchanger 1 transporter. Nat Struct Mol Biol, 30(10), 1495-1504 (2023). [doi: 10.1038/s41594-023-01085-6]

High ImpactCited 2 timesLie Wang, Ming Zhou, Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis. Nat. Comm., 14(1), 2753 (2023). [doi: 10.1038/s41467-023-38003-9]

High ImpactWilliam D. Ton, Yue Wang, Pengxin Chai, Cisloynny Beauchamp-Perez, Nicholas T. Flint, Lindsay G. Lammers, Hao Xiong, Kai Zhang, Steven M. Markus, Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport. Nat Struct Mol Biol, 30(9), 1365-1379 (2023). [doi: 10.1038/s41594-023-01010-x]

High ImpactChangxu Pang, Jin Chai, Ping Zhu, John Shanklin, Qun Liu, Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters. Nat. Comm., 14(1), 3404 (2023). [doi: 10.1038/s41467-023-39010-6]

High ImpactCited 3 timesArthur Neuberger, Mai Oda, Yury A. Nikolaev, Kirill D. Nadezhdin, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Alexander I. Sobolevsky, Human TRPV1 structure and inhibition by the analgesic SB-366791. Nat. Comm., 14(1), 2451 (2023). [doi: 10.1038/s41467-023-38162-9]

High ImpactJin Chai, Gongrui Guo, Sean M. McSweeney, John Shanklin, Qun Liu, Structural basis for enzymatic terminal C–H bond functionalization of alkanes. Nat Struct Mol Biol, 30(4), 521-526 (2023). [doi: 10.1038/s41594-023-00958-0]

High ImpactMichal Pyzik, Lisa K. Kozicky, Amit K. Gandhi, Richard S. Blumberg, The therapeutic age of the neonatal Fc receptor. Nat Rev Immunol, 23(7), 415-432 (2023). [doi: 10.1038/s41577-022-00821-1]

Cited 2 timesChristopher J. Gisriel, Gaozhong Shen, David A. Flesher, Vasily Kurashov, John H. Golbeck, Gary W. Brudvig, Muhamed Amin, Donald A. Bryant, Structure of a dimeric photosystem II complex from a cyanobacterium acclimated to far-red light. J. Biol. Chem., 299(1), 102815 (2023). [doi: 10.1016/j.jbc.2022.102815]

Clara G. Altomare, Daniel C. Adelsberg, Juan Manuel Carreno, Iden A. Sapse, Fatima Amanat, Ali H. Ellebedy, Viviana Simon, Florian Krammer, Goran Bajic, Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain. mBio, 13(3) (2022). [doi: 10.1128/mbio.03580-21]

High ImpactCited 31 timesChunyi Hu, Sam P. B. van Beljouw, Ki Hyun Nam, Gabriel Schuler, Fran Ding, Yanru Cui, Alicia Rodríguez-Molina, Anna C. Haagsma, Menno Valk, Martin Pabst, Stan J. J. Brouns, Ailong Ke, Craspase is a CRISPR RNA-guided, RNA-activated protease. Science, 377(6612), 1278-1285 (2022). [doi: 10.1126/science.add5064]

Cited 5 timesSagar Sridhara, Jay Rai, Charlisa Whyms, Hemant Goswami, Huan He, Walter Woodside, Michael P. Terns, Hong Li, Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex. Commun Biol, 5(1), 279 (2022). [doi: 10.1038/s42003-022-03187-1]

Hemant N Goswami, Jay Rai, Anuska Das, Hong Li, Molecular mechanism of active Cas7-11 in processing CRISPR RNA and interfering target RNA, 11 (2022). [doi: 10.7554/eLife.81678]

Cited 2 timesWu Liu, Martien Schoonen, Tong Wang, Sean McSweeney, Qun Liu, Cryo-EM structure of transmembrane AAA+ protease FtsH in the ADP state. Commun Biol, 5(1), 257 (2022). [doi: 10.1038/s42003-022-03213-2]

High ImpactCited 8 timesLei Peng, Yingxia Hu, Madeleine C. Mankowski, Ping Ren, Rita E. Chen, Jin Wei, Min Zhao, Tongqing Li, Therese Tripler, Lupeng Ye, Ryan D. Chow, Zhenhao Fang, Chunxiang Wu, Matthew B. Dong, Matthew Cook, Guilin Wang, Paul Clark, Bryce Nelson, Daryl Klein, Richard Sutton, Michael S. Diamond, Craig B. Wilen, Yong Xiong, Sidi Chen, Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat. Comm., 13(1), 1638 (2022). [doi: 10.1038/s41467-022-29288-3]

High ImpactCited 20 timesGabriel Schuler, Chunyi Hu, Ailong Ke, Structural basis for RNA-guided DNA cleavage by IscB-ωRNA and mechanistic comparison with Cas9. Science, 376(6600), 1476-1481 (2022). [doi: 10.1126/science.abq7220]

Cited 4 timesYu Zhao, Jay Rai, Hongguo Yu, Hong Li, CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations. Structure, 30(7), 983-992.e5 (2022). [doi: 10.1016/j.str.2022.04.002]

Cited 25 timesChristopher J. Gisriel, Gaozhong Shen, Ming-Yang Ho, Vasily Kurashov, David A. Flesher, Jimin Wang, William H. Armstrong, John H. Golbeck, David J. Vinyard, Richard J. Debus, Gary W. Brudvig, Donald A. Bryant, Marilyn R. Gunner, Structure of a monomeric photosystem II core complex from a cyanobacterium acclimated to far-red light reveals the functions of chlorophylls d and f. J. Biol. Chem., 298(1), 101424 (2022). [doi: 10.1016/j.jbc.2021.101424]

Cited 17 timesChristopher J. Gisriel, David A. Flesher, Gaozhong Shen, Jimin Wang, Ming-Yang Ho, Gary W. Brudvig, Donald A. Bryant, Structure of a photosystem I-ferredoxin complex from a marine cyanobacterium provides insights into far-red light photoacclimation. J. Biol. Chem., 298(1), 101408 (2022). [doi: 10.1016/j.jbc.2021.101408]

High ImpactCited 46 timesJin Chai, Yuanheng Cai, Changxu Pang, Liguo Wang, Sean McSweeney, John Shanklin, Qun Liu, Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1. Nat. Comm., 12(1), 3433 (2021). [doi: 10.1038/s41467-021-23533-x]

Publication Summary

Year High Impact* Total**
2024 5 8
2023 13 17
2022 3 10
2021 1 1
Total 22 36

*High Impact = Journal Impact Factor > 7.0

**The total publication count includes all journal articles, peer-reviewed conference proceedings, books, book chapters, and dissertations.

Publications Database

The database contains a record of all publications reported to LBMS and can be searched by author, instrument, journal, year, and DOI.

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