Frontier Microfocusing Macromolecular Crystallography

Kate Magante, Candice M. Armstrong, Mark Lee, Aaron T. Smith, The Structure of the Full Catalytic Cycle of Vibrio cholerae NFeoB. J. Mol. Biol., 438(9), 169727, PMCID: 41724262 (2026). [doi: 10.1016/j.jmb.2026.169727]

Jessica E Besaw, Jorg Reichenwallner, Evelyn Y Chen, Paule Hermet-Teesalu, Anastassiya Tregubenko, Kyumhyuk Kim, Takefumi Morizumi, Mart Jr Ustav, Oliver P Ernst, Structural characterization of the Cu(II)-NTA spin label on alpha-helices by X-ray crystallography and electron paramagnetic resonance.. Structure, PMCID: 41794029 (2026). [doi: 10.1016/j.str.2026.01.010]

Ranjuna Weerasekera, Alexis Moreau, Xin Huang, Anna Potapova, Carmen Schwechheimer, Rajan Kandel, Yun Huynh, Owen Cannizzo, Ryan Gordon, Emma Gerace, Alexander J Hinbest, Yiyan Yang, Xiaofang Jiang, Robert J Woods, Jing Yan, Fitnat H Yildiz, Rich Olson, Crystal structure of Vibrio choleraepolysaccharide lyase RbmB bound to Vibriopolysaccharide (VPS) fragments provides insights into substrate recognition and cleavage.. Proceedings of the National Academy of Sciences of the United States of America, 123(11), e2534280123-null, PMCID: 41805565 (2026). [doi: 10.1073/pnas.2534280123]

High Impact Sonomi Yamaguchi, Samantha G. Fernandez, Douglas R. Wassarman, Marlen Luders, Frank Schwede, Philip J. Kranzusch, Nucleotide signals coordinate activation and inhibition of bacterial immunity. Nature, PMCID: 41708866 (2026). [doi: 10.1038/s41586-026-10135-0]

Hai Minh Ta, Banumathi Sankaran, Eric D. Roush, Josephine C. Ferreon, Allan Chris M. Ferreon, Choel Kim, Fyn-Saracatinib Complex Structure Reveals an Active State-like Conformation. Int. J. Mol. Sci., 27(3), 1143, PMCID: 41683573 (2026). [doi: 10.3390/ijms27031143]

High Impact Bo Liu, Brandon Lu, Arpan De, Kyoungdu Kim, Lara Perren, Karol Woloszyn, Galina Petrova, Ruihao Li, Chu-fan Yang, Chengde Mao, Antia S. Botana, Yoel P. Ohayon, James W. Canary, Ruojie Sha, M. P. Anantram, Simon Vecchioni, Joshua Hihath, Electrical control of a metal-mediated DNA memory. Matter, 9(1), 102470 (2026). [doi: 10.1016/j.matt.2025.102470]

Nushrat J. Hoque, Sarah R. Pope, Varun Venkatakrishnan, David O. Olori, Noah A. Brady, Dayna C. Patterson, Ganesh S. Anand, Yilin Liu, Amie K. Boal, Emily E. Weinert, Cooperative ligand binding in a bacterial heme-based oxygen sensor. J. Biol. Chem., 302(2), 111025, PMCID: 41371339 (2026). [doi: 10.1016/j.jbc.2025.111025]

Dieter Waschbusch, Prosenjit Pal, Raja S. Nirujogi, Melanie Cavin, Jaijeet Singh, Dario R. Alessi, Amir R. Khan, Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif. Structure, 34(2), PMCID: 41314214 (2026). [doi: 10.1016/j.str.2025.11.003]

High Impact Hasan Al Banna, Naba Krishna Das, Marina Kalinina, Guangming Lu, Maira Usman, Deepak Koirala, Structures of the eIF4G-binding RNA domains among picornaviral IRES types are topologically conserved.. Nat. Comm., PMCID: 41690908 (2026). [doi: 10.1038/s41467-026-69554-2]

Eswar R Reddem, Farhad Forouhar, Cheng Liu, Sarah K Stevens, Andreas Jekle, Ching-Wen Chang, Neelam Oswal, David C McGowan, Koen Vandyck, David B Smith, Pierre Raboisson, Leonid N Beigelman, Phinikoula S Katsamba, Fabiana Bahna, Seetha Mannepalli, Lawrence Blatt, David Perlin, Julian A Symons, Lawrence Shapiro, Antitsa D Stoycheva, Structural basis for pan-coronavirus inhibition of 3CL protease.. Structure, PMCID: 41650964 (2026). [doi: 10.1016/j.str.2026.01.003]

Tahereh Damghani, Shenghan Song, Kaly S. Lin, Jianing Li, David E. Heppner, Structural Studies of Fourth-Generation EGFR Inhibitors Reveal Insights into Selective T790M and C797S Targeting. ACS Med. Chem. Lett. (2026). [doi: 10.1021/acsmedchemlett.5c00725]

Kalyani Thakur, Ian Fucci, Joshua Pandian, Kiall F. Suazo, Diana C. F. Monteiro, Euna Yoo, Structure-Guided Optimization of 4-Chloro-Pyrazolopyridine Analogs for Covalent PREP Inhibition. J. Med. Chem., 69(2), 1303-1321, PMCID: 41512187 (2026). [doi: 10.1021/acs.jmedchem.5c02680]

High Impact Hajar Al-Zarah, Vidya R. Singh, Karol Woloszyn, Lara Perren, Judah Klingsberg, Gregor Posnjak, Tim Liedl, Trinanjana Mandal, Chengde Mao, Joshua Hihath, Yoel P. Ohayon, James W. Canary, Satoshi Habuchi, Ruojie Sha, Simon Vecchioni, DNA Glass: Encasing Diffraction-Quality, Mesoporous DNA Crystals in Architected Silica. Angew. Chem. Int. Ed., 65(1), PMCID: 41178261 (2026). [doi: 10.1002/anie.202516745]

High Impact Yingying Zhang, Franklin D. Kennedy, Traci M. Tanaka Hall, Crystal structures of Caenorhabditis elegans PUF-3 depict plasticity of RNA recognition that enables germline gene regulation. Nucleic Acids Res., 54(1), gkaf1431, PMCID: 41495898 (2026). [doi: 10.1093/nar/gkaf1431]

High ImpactManoj Jangra, Dmitrii Y. Travin, Elena V. Aleksandrova, Manpreet Kaur, Lena Darwish, Kalinka Koteva, Dorota Klepacki, Wenliang Wang, Maya Tiffany, Akosiererem Sokaribo, Xuefei Chen, Zixin Deng, Meifeng Tao, Brian K. Coombes, Nora Vázquez-Laslop, Yury S. Polikanov, Alexander S. Mankin, Gerard D. Wright, Author Correction: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome. Nature, 645(8082), E11-E11 (2025). [doi: 10.1038/s41586-025-09597-5]

High Impact Manju Ojha, Lucia Hudson, Amanda Photenhauer, Trinity Zang, Lauren Lerew, Solen Ekesan, Jason Daniels, Megan Nguyen, Hardik Paudyal, Darrin M. York, Melanie D. Ohi, Jan Marchant, Paul D. Bieniasz, Deepak Koirala, Mutation-driven RRE stem-loop II conformational change induces HIV-1 nuclear export dysfunction. Nucleic Acids Res., 53(12), gkaf583, PMCID: 40613716 (2025). [doi: 10.1093/nar/gkaf583]

High Impact Yamanappa Hunashal, Matthieu Fonvielle, Masumi Takayama Kobayashi, Meng S. Choy, Ganesan Senthil Kumar, Paul Ugalde Silva, Yucheng Liang, Charlene Desbonnet, Louis B. Rice, Michel Arthur, Rebecca Page, Wolfgang Peti, Peptidoglycan recruitment by a penicillin binding protein. Nat. Comm., 16(1), 11244, PMCID: 41407687 (2025). [doi: 10.1038/s41467-025-66095-y]

Jessica D. Tolbert, Kacey M. Talbot, Christopher M. Bollinger, F. Jon Kull, George P. Munson, Charles R. Midgett, Characterization of the ligand binding pocket of the virulence regulator Rns, a member of the AraC/XylS family of transcription factors. mSphere, 10(8), PMCID: 40704798 (2025). [doi: 10.1128/msphere.00115-25]

Bing Wang, Rui Yang, Chun Wan, Yuan Tian, Jingyi Wu, Taiwo Scholes Adewole, Sayantan Roy, Suzhao Li, Jingshi Shen, Qian Yin, Structural basis of pseudoGTPase-mediated protein-protein interactions. Structure, 33(10), 1676-1687, PMCID: 40752490 (2025). [doi: 10.1016/j.str.2025.07.009]

Ioannis Karageorgos, David Travis Gallagher, D. Travis Gallagher, Heptad insertion extends the E. coli ROP protein by 50 %. BioDesign Research, 8(1), 100061 (2025). [doi: 10.1016/j.bidere.2025.100061]

Sashank Agrawal, Monika Jain, Daniella Marinelli, So Yeon Cho, Bryan Briney, Ian A. Wilson, Structural hijacking of FcRn by human astrovirus spikes reveals conserved epitopes for broad-spectrum antivirals. Cell Rep., 44(12), 116679, PMCID: 41389202 (2025). [doi: 10.1016/j.celrep.2025.116679]

Jackson C. Lin, Jameson R. Averill, Hunmin Jung, Deciphering the Role of DNA Polymerase Eta on the Incorporation and Bypass of Inosine and Cell Cycle Arrest. Int. J. Mol. Sci., 26(24), 12030, PMCID: 41465459 (2025). [doi: 10.3390/ijms262412030]

Matthew N. Gaynes, Kristin R. Osika, David W. Christianson, Structure and Mechanism of Avermitilol Synthase, a Sesquiterpene Cyclase That Generates a Highly Strained 6-6-3 Tricyclic Alcohol. Biochemistry, 64(24), 4830-4840, PMCID: 41326024 (2025). [doi: 10.1021/acs.biochem.5c00565]

High Impact Zhiying Zhang, Thomas C. Todeschini, Yi Wu, Roman Kogay, Ameena Naji, Joaquin Cardenas Rodriguez, Rupavidhya Mondi, Daniel Kaganovich, David W. Taylor, Jack P. K. Bravo, Marianna Teplova, Triana Amen, Eugene V. Koonin, Dinshaw J. Patel, Franklin L. Nobrega, Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites. Cell, 188(21), 5862-5877, PMCID: 40730155 (2025). [doi: 10.1016/j.cell.2025.07.002]

Xander Calicdan, Oriana S. Fisher, Byung Hak Ha, Titus J. Boggon, Amy L. Stiegler, Nickel Binding to the c-Src SH3 Domain Facilitates Crystallization. Protein Peptide Lett., 32(9), 679-692, PMCID: 41088944 (2025). [doi: 10.2174/0109298665417324250929120040]

Andrew D Huber, Efren Garcia-Maldonado, Wenwei Lin, Shyaron Poudel, Jing Wu, Darcie J Miller, Taosheng Chen, D. Andrew, Darcie J. Miller, Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators. Structure, 34(1), PMCID: 41138720 (2025). [doi: 10.1016/j.str.2025.09.011]

Aweon Richards, Peptide-Based Inhibition of the Bacterial DnaK Chaperone Network, PhD Thesis Thesis. NYU, New York (2025).

High Impact Gizem Gokce-Alpkilic, Buwei Huang, Andi Liu, Lieselotte S. M. Kreuk, Yaxi Wang, Victor Adebomi, Yensi Flores Bueso, Asim K. Bera, Alex Kang, Stacey R. Gerben, Stephen Rettie, Dionne K. Vafeados, Nicole Roullier, Inna Goreshnik, Xinting Li, David Baker, Joshua J. Woodward, Joseph D. Mougous, Gaurav Bhardwaj, De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor. Angew. Chem. Int. Ed., 64(52), PMCID: 41117072 (2025). [doi: 10.1002/anie.202516058]

High Impact Naba Krishna Das, Alisha Patel, Reem Abdelghani, Deepak Koirala, Structural basis for 3C and 3CD recruitment by enteroviral genomes during negative-strand RNA synthesis. Nat. Comm., 16(1), 9293, PMCID: 41120315 (2025). [doi: 10.1038/s41467-025-64376-0]

High Impact Yanan Du, Anyarat Thanapipatsiri, Jesus J. Blancas Cortez, Xavier E. Salas-Sola, Chi-Yun Lin, Amie K. Boal, Carsten Krebs, J. Martin Bollinger Jr, Kenichi Yokoyama, Azetidine amino acid biosynthesis by non-haem iron-dependent enzymes. Nature Chem., 18(3), PMCID: 41120677 (2025). [doi: 10.1038/s41557-025-01958-x]

Juliet Gonzales, Tynan Young, Hyeran Choi, Miso Park, Yead Jewel, Chengcheng Fan, Rahul Purohit, Pamela J. Bjorkman, John C. Williams, Development of an ultrahigh affinity, trimeric ACE2 biologic as a universal SARS-CoV-2 antagonist. Commun Biol, 8(1), 1428, PMCID: 41053501 (2025). [doi: 10.1038/s42003-025-08819-w]

High Impact Yixing Suo, Ziran Jiang, Graham W. Heberlig, Elsabella Y. Wang, Banumathi Sankaran, James J. La Clair, Michael D. Burkart, Role of Human Mitochondrial Ketosynthase in Long-Chain Fatty Acid Biosynthesis. J. Am. Chem. Soc., 147(36), 33248-33255, PMCID: 40891531 (2025). [doi: 10.1021/jacs.5c10318]

High Impact Thomas M DeAngelo, Utsarga Adhikary, Kyle J Korshavn, Hyuk-Soo Seo, Clara R Brotzen-Smith, Christina M Camara, Sirano Dhe-Paganon, Gregory H Bird, Thomas E Wales, Loren D Walensky, Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices.. Nat. Comm., 16(1), 8623-null, PMCID: 41022713 (2025). [doi: 10.1038/s41467-025-63657-y]

Jin Gan, Prachi Dabhade, Charlotte Wijne, William McKibben, Simeon D. Draganov, Hedib Alrawili, Zhen-Yu Jim Sun, Jack W. Houghton, Edward W. Tate, Camille Le Gall, Pavana Suresh, Novalia Pishesha, Adan Pinto-Fernandez, Thomas U. Schwartz, Hidde L. Ploegh, Identification and characterization of nanobodies specific for the human ubiquitin-like ISG15 protein. The Journal of biological chemistry, 301(9), 110564, PMCID: 40774387 (2025). [doi: 10.1016/J.JBC.2025.110564]

Adam M Chazin-Gray, Tuscan R Thompson, Edward D B Lopatto, Pearl Magala, Patrick W Erickson, Andrew C Hunt, Anna Manchenko, Pavel Aprikian, Veronika Tchesnokova, Irina Basova, Denise A Sanick, Kevin O Tamadonfar, Morgan R Timm, Jerome S Pinkner, Karen W Dodson, Alex Kang, Emily Joyce, Asim K Bera, Aaron J Schmitz, Ali H Ellebedy, Kelli L Hvorecny, Mark J Cartwright, Andyna Vernet, Sarai Bardales, Desmond White, Rachel E Klevit, Evgeni V Sokurenko, Scott J Hultgren, David Baker, De NovoDesign of Miniprotein Inhibitors of Bacterial Adhesins.. bioRxiv : the preprint server for biology, PMCID: 40894640 (2025). [doi: 10.1101/2025.08.18.670751]

David E Kim, Joseph L Watson, David Juergens, Sagardip Majumder, Ria Sonigra, Stacey R Gerben, Alex Kang, Asim K Bera, Xinting Li, David Baker, Parametrically guided design of beta barrels and transmembrane nanopores using deep learning.. Proceedings of the National Academy of Sciences of the United States of America, 122(38), e2425459122-null, PMCID: 40953261 (2025). [doi: 10.1073/PNAS.2425459122]

Gabrielle R Budziszewski, Miranda L Lynch, M Elizabeth Snell, Diana Cf Monteiro, Sarah Ej Bowman, Burkholderia pseudomalleirubrerythrin promiscuously binds metals in a structurally pre-formed bimetallic binding site.. bioRxiv : the preprint server for biology, PMCID: 40501712 (2025). [doi: 10.1101/2025.06.01.657255]

High Impact Renee B Chang, Hunter C Toyoda, Samuel J Hobbs, Romi Hadary, Desmond Richmond-Buccola, Tanita Wein, Ilya Osterman, Nils Burger, Edward T Chouchani, Rotem Sorek, Philip J Kranzusch, A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense.. Mol. Cell, 85(16), 3151-null, PMCID: 40845805 (2025). [doi: 10.1016/j.molcel.2025.07.016]

High Impact Santhosh Gatreddi, Julian Urdiain-Arraiza, Benoit Desguin, Robert P. Hausinger, Jian Hu, Structural Basis for the Catalysis and Substrate Specificity of a LarA Racemase with a Broad Substrate Spectrum. ACS Catal., 15(4), 2857-2866, PMCID: 40013250 (2025). [doi: 10.1021/acscatal.4c07804]

Salma Kwarteng, Jacquelyn Wilhelm, Merna Salama, Monika Salama, Klarissa Hollander, Karen S Anderson, Nina M Goodey, Kathleen M Frey, A virtual screening strategy to repurpose antifolate compounds as W.bancrofti DHFR inhibitors.. BioOrg. Med. Chem., 129, 130370-null, PMCID: 40812516 (2025). [doi: 10.1016/J.BMCL.2025.130370]

Ajeak Vigneswaran, Ke Shi, Hideki Aihara, Robert L 3rd Evans, Michael P Latham, Crystal structure of the folded domains of Xrs2 from Saccharomyces cerevisiae.. Acta Cryst Sect F, 81(Pt 9), 365-373, PMCID: 40767353 (2025). [doi: 10.1107/S2053230X25006867]

High Impact Wei Yang, Derrick R. Hicks, Agnidipta Ghosh, Tristin A. Schwartze, Brian Conventry, Inna Goreshnik, Aza Allen, Samer F. Halabiya, Chan Johng Kim, Cynthia S. Hinck, David S. Lee, Asim K. Bera, Zhe Li, Yujia Wang, Thomas Schlichthaerle, Longxing Cao, Buwei Huang, Sarah Garrett, Stacey R. Gerben, Stephen Rettie, Piper Heine, Analisa Murray, Natasha Edman, Lauren Carter, Lance Stewart, Steven C. Almo, Andrew P. Hinck, David Baker, Design of high-affinity binders to immune modulating receptors for cancer immunotherapy. Nat. Comm., 16(1), 2001, PMCID: 40011465 (2025). [doi: 10.1038/s41467-025-57192-z]

Douglas R Wassarman, Patrick Pfaff, Joao A Paulo, Steven P Gygi, Kevan M Shokat, Philip J Kranzusch, Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity.. Science (New York, N.Y.), 389(6767), 1347-1352, PMCID: 40997174 (2025). [doi: 10.1126/SCIENCE.ADX6053]

High Impact Erin Skeens, Federica Maschietto, Ramu Manjula, Shanelle Shillingford, James Murphy, Elias J. Lolis, Victor S. Batista, Anton M. Bennett, George P. Lisi, Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase. Nat. Comm., 16(1), 7011, PMCID: 40745179 (2025). [doi: 10.1038/S41467-025-62150-W]

High Impact Adam J. Broerman, Christoph Pollmann, Yang Zhao, Mauriz A. Lichtenstein, Mark D. Jackson, Maxx H. Tessmer, Won Hee Ryu, Masato Ogishi, Mohamad H. Abedi, Danny D. Sahtoe, Aza Allen, Alex Kang, Joshmyn de la Cruz, Evans Brackenbrough, Banumathi Sankaran, Asim K. Bera, Daniel M. Zuckerman, Stefan Stoll, K. Christopher Garcia, Florian Praetorius, Jacob Piehler, David Baker, Design of facilitated dissociation enables timing of cytokine signalling. Nature, 647(8089), 528-535 (2025). [doi: 10.1038/S41586-025-09549-Z]

Tahereh Damghani, Surbhi P. Chitnis, Omobolanle A. Abidakun, Kishan B. Patel, Kaly S. Lin, Emily A. Ouellette, Abigail M. Lantry, David E. Heppner, Profiling and Optimizing Targeted Covalent Inhibitors through EGFR-Guided Studies. J. Med. Chem., 68(16), 17917-17932, PMCID: 40801664 (2025). [doi: 10.1021/acs.jmedchem.5c01661]

Kriti Khatri, Alyssa Ball, Jill Glesner, Christina Linn, Lisa D. Vailes, Sabina Wunschmann, Scott A. Gabel, Jian Zhang, R. Stokes Peebles, Tomasz Borowski, Geoffrey A. Mueller, Martin D. Chapman Jr, Scott A. Smith, Anna Pomes, Maksymilian Chruszcz, Human IgE monoclonal antibodies define two unusual epitopes trapping dog allergen Can f 1 in different conformations. Protein Sci., 34(9), e70269, PMCID: 40828364 (2025). [doi: 10.1002/pro.70269]

High ImpactLuis Linares-Otoya, Jaden D. Shirkey, Bhuwan Khatri Chhetri, Amira Mira, Abhishek Biswas, Samuel L. Neff, Maria V. Linares-Otoya, Ye Chen, Julio V. Campos-Florian, Mayar L. Ganoza-Yupanqui, Philip D. Jeffrey, Frederick M. Hughson, Mohamed S. Donia, Discovery of a widespread chemical signalling pathway in the Bacteroidota. Nature, 646(8084), 423-432 (2025). [doi: 10.1038/s41586-025-09418-9]

High Impact Kejia Wu, Hanlun Jiang, Derrick R. Hicks, Caixuan Liu, Edin Muratspahic, Theresa A. Ramelot, Yuexuan Liu, Kerrie McNally, Sebastian Kenny, Andrei Mihut, Amit Gaur, Brian Coventry, Wei Chen, Asim K. Bera, Alex Kang, Stacey Gerben, Mila Ya-Lan Lamb, Analisa Murray, Xinting Li, Madison A. Kennedy, Wei Yang, Zihao Song, Gudrun Schober, Stuart M. Brierley, John O'Neill, Michael H. Gelb, Gaetano T. Montelione, Emmanuel Derivery, David Baker, Design of intrinsically disordered region binding proteins. Science, 389(6757), eadr8063, PMCID: 40674483 (2025). [doi: 10.1126/science.adr8063]

Joey L Galindo, Philip D Jeffrey, Angela Zhu, A James Link, Jonathan M Conway, Joey L. Galindo, Philip Jeffrey, A. James Link, Jonathan M. Conway, Functional and structural characterization of AtAbf43C: an exo-1,5-α-L-arabinofuranosidase from Acetivibrio thermocellus DSM1313. Biochem. J., 482(16), 1181-1195, PMCID: 40785600 (2025). [doi: 10.1042/BCJ20253186]

High Impact Yanan Du, Julian Dong, Matthew M. Draelos, Laura N. Collazo-Perez, Sean H. Majer, Amie K. Boal, Kenichi Yokoyama, Unusual O-H Activation-Initiated C-C Bond Cleavage Reaction by a Nonheme Fe Enzyme in Antifungal Nucleoside Biosynthesis. J. Am. Chem. Soc., 147(33), 30163-30177, PMCID: 40787846 (2025). [doi: 10.1021/jacs.5c08400]

Jake Colautti, Youngchang Kim, John C Whitney, Antibacterial ADP-ribosyl cyclase toxins inhibit bacterial growth by rapidly depleting NAD(P).. The Journal of biological chemistry, 301(8), 110491-null, PMCID: 40680842 (2025). [doi: 10.1016/j.jbc.2025.110491]

High Impact Ashok Nuthanakanti, Megan Korn, Rose Levenson-Palmer, Yue Wu, Nandhini Rajesh Babu, Xuhui Huang, Robert S. Banh, Joel G. Belasco, Alexander Serganov, ApaH decaps Np₄N-capped RNAs in two alternative orientations. Nat. Chem. Biol., PMCID: 40789943 (2025). [doi: 10.1038/s41589-025-01991-4]

High Impact Luying Pan, Jake C. Lachowicz, Isaac Paddy, Yutong Xu, Qianyi Yang, Cynthia Zizola, Amy Milne, Tyler L. Grove, Maria-Eirini Pandelia, Activation and Allostery in a Fungal SAMHD1 Hydrolase: An Evolutionary Blueprint for dNTP Catabolism. JACS Au, 5(4), 1862-1874, PMCID: 40313832 (2025). [doi: 10.1021/jacsau.5c00090]

High Impact Fabian-Alexander Schleich, Shridhar Bale, Javier Guenaga, Gabriel Ozorowski, Monika Adori, Xiaohe Lin, Xaquin Castro Dopico, Richard Wilson, Mark Chernyshev, Alma Teresia Cotgreave, Marco Mandolesi, Jocelyn Cluff, Esmeralda D. Doyle, Leigh M. Sewall, Wen-Hsin Lee, Shiyu Zhang, Sijy O'Dell, Brandon S. Healy, Deuk Lim, Vanessa R. Lewis, Elana Ben-Akiva, Darrell J. Irvine, Nicole A. Doria-Rose, Martin Corcoran, Diane Carnathan, Guido Silvestri, Ian A. Wilson, Andrew B. Ward, Gunilla B. Karlsson Hedestam, Richard T. Wyatt, Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer. Immunity, 58(6), PMCID: 40339576 (2025). [doi: 10.1016/j.immuni.2025.04.010]

High Impact Dziugas Sabonis, Carmel Avraham, Renee B. Chang, Allen Lu, Ehud Herbst, Arunas Silanskas, Deividas Vilutis, Azita Leavitt, Erez Yirmiya, Hunter C. Toyoda, Audrone Ruksenaite, Mindaugas Zaremba, Ilya Osterman, Gil Amitai, Philip J. Kranzusch, Rotem Sorek, Giedre Tamulaitiene, TIR domains produce histidine-ADPR as an immune signal in bacteria. Nature, 642(8067), PMCID: 40307559 (2025). [doi: 10.1038/s41586-025-08930-2]

High Impact Inna V. Krieger, Paridhi Sukheja, Baiyuan Yang, Su Tang, Daniel Selle, Ashley Woods, Curtis Engelhart, Pradeep Kumar, Michael B. Harbut, Dongdong Liu, Brendan Tsuda, Bo Qin, Grant A. L. Bare, Gencheng Li, Victor Chi, Julian Gambacurta, Janine Hvizdos, Matthew Reagan, Isabelle L. Jones, Lisa M. Massoudi, Lisa K. Woolhiser, Alessandro Cascioferro, Erica Kundrick, Parul Singh, William Reiley, Thomas R. Ioerger, Dilipkumar Reddy Kandula, Jacob W. McCabe, Taijie Guo, David Alland, Helena I. Boshoff, Dirk Schnappinger, Gregory T. Robertson, Khisi Mdluli, Kyoung-Jin Lee, Jiajia Dong, Shuangwei Li, Peter G. Schultz, Sean B. Joseph, Melissa S. Love, K. Barry Sharpless, H. Michael Petrassi, Arnab K. Chatterjee, James C. Sacchettini, Case W. McNamara, SuFEx-based antitubercular compound irreversibly inhibits Pks13. Nature, 645(8081), 755-763 (2025). [doi: 10.1038/s41586-025-09286-3]

Mark E. Kowalewski, Sebastian Zagler, Matthew R. Redinbo, Structural Insights into Selectively Targeting Candida albicans Hsp90. Biochemistry, 64(11), 2401-2411, PMCID: 40397669 (2025). [doi: 10.1021/acs.biochem.5c00015]

High Impact Antonio Cuevas-Navarro, Yasin Pourfarjam, Feng Hu, Diego J. Rodriguez, Alberto Vides, Ben Sang, Shijie Fan, Yehuda Goldgur, Elisa de Stanchina, Piro Lito, Pharmacological restoration of GTP hydrolysis by mutant RAS. Nature, 637(8044), PMCID: 39476862 (2025). [doi: 10.1038/s41586-024-08283-2]

Sarah N. Zvornicanin, Ala M. Shaqra, Julia Flynn, Heidi Carias Martinez, Weiping Jia, Stephanie Moquin, Dustin Dovala, Daniel N. Bolon, Nese Kurt Yilmaz, Celia A. Schiffer, Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50. mBio, 16(5), PMCID: 40183562 (2025). [doi: 10.1128/mbio.04068-24]

High Impact Ronnie Richardson-Matthews, Kateryna Velko, Bitan Bhunia, Sabari Ghosh, Julia Oktawiec, Joseph S. Brunzelle, Viet Thuc Dang, Andy I. Nguyen, Metal-α-Helix Peptide Frameworks. J. Am. Chem. Soc., 147(20), 17433-17447, PMCID: 40328673 (2025). [doi: 10.1021/jacs.5c04078]

High Impact Usha Nair, Ziqi Feng, Madhav Akauliya, Abigail G. Esposito, Charles R. Crain, Edward D. Lamperti, Thavaleak Prum, John E. Warner, Lisa Madungwe, Gordon A. Dale, Julie Boucau, Gaurav D. Gaiha, Meng Yuan, Ian A. Wilson, Facundo D. Batista, In vivo antibody diversification targeting a conserved coronavirus epitope. J. Exp. Med., 222(10), e20241563, PMCID: 40674170 (2025). [doi: 10.1084/jem.20241563]

High Impact Manoj Jangra, Dmitrii Y. Travin, Elena V. Aleksandrova, Manpreet Kaur, Lena Darwish, Kalinka Koteva, Dorota Klepacki, Wenliang Wang, Maya Tiffany, Akosiererem Sokaribo, Brian K. Coombes, Nora Vazquez-Laslop, Yury S. Polikanov, Alexander S. Mankin, Gerard D. Wright, Xuefei Chen, Zixin Deng, Meifeng Tao, Nora Vázquez-Laslop, A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome. Nature, 640(8060), 1022-1030 (2025). [doi: 10.1038/s41586-025-08723-7]

High Impact Koji Terayama, Shinji Furuzono, Nicole Fer, Wupeng Yan, Lucy C. Young, Daniel J. Czyzyk, Ruby Goldstein de Salazar, Masato Sasaki, Akihiro Uozumi, Masahiro Konishi, Shoichi Kanda, Yoshitaka Sogawa, Mitsuhiro Yamaguchi, Takashi Tsuji, Junichi Kuroyanagi, Mayumi Hayashi, Yuji Ogura, Dhirendra K. Simanshu, Kazuishi Kubota, Jun Tanaka, Frank McCormick, Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin. Science, 389(6758), 402-408, PMCID: 40705882 (2025). [doi: 10.1126/science.adr9097]

High Impact Olga A. Esakova, Douglas M. Warui, Syam Sundar Neti, John N. Alumasa, Squire J. Booker, Structural basis for catalysis by human lipoyl synthase. Nat. Comm., 16(1), 6355, PMCID: 40640146 (2025). [doi: 10.1038/s41467-025-61393-x]

Jake C. Lachowicz, Steven Grudman, Jeffrey B. Bonanno, Andras Fiser, Tyler L. Grove, Structural insights from active site variants and β-8 loop interactions in viperin-like enzymes. Structure, 33(7), 1263-1274.e5 (2025). [doi: 10.1016/j.str.2025.04.009]

Him Shweta, Kushol Gupta, Yufeng Zhou, Xiaonan Cui, Selene Li, Zhe Lu, Yale E. Goldman, Jody A. Dantzig, Characterization and structural basis for the brightness of mCLIFY: A novel monomeric and circularly permuted bright yellow fluorescent protein. Biophys. J., 124(13), 2133-2149, PMCID: 40405461 (2025). [doi: 10.1016/j.bpj.2025.05.012]

High ImpactStephen A. Rettie, David Juergens, Victor Adebomi, Yensi Flores Bueso, Qinqin Zhao, Alexandria N. Leveille, Andi Liu, Asim K. Bera, Joana A. Wilms, Alina Üffing, Alex Kang, Evans Brackenbrough, Mila Lamb, Stacey R. Gerben, Analisa Murray, Paul M. Levine, Maika Schneider, Vibha Vasireddy, Sergey Ovchinnikov, Oliver H. Weiergräber, Dieter Willbold, Joshua A. Kritzer, Joseph D. Mougous, David Baker, Frank DiMaio, Gaurav Bhardwaj, Stephen A. Rettie, David Juergens, Victor Adebomi, Yensi Flores Bueso, Qinqin Zhao, Alexandria N. Leveille, Andi Liu, Asim K. Bera, Joana A. Wilms, Alina Ueffing, Alex Kang, Evans Brackenbrough, Mila Lamb, Stacey R. Gerben, Analisa Murray, Paul M. Levine, Maika Schneider, Vibha Vasireddy, Sergey Ovchinnikov, Oliver H. Weiergraeber, Dieter Willbold, Joshua A. Kritzer, Joseph D. Mougous, David Baker, Frank Dimaio, Gaurav Bhardwaj, Accurate de novo design of high-affinity protein-binding macrocycles using deep learning. Nat. Chem. Biol., 21(12), 1948-1956 (2025). [doi: 10.1038/s41589-025-01929-w]

J. Aishima, B. Andi, L. Berman, J. Byrnes, S. Chodankar, E. Farquhar, M. R. Fuchs, J. Jakoncic, D. Kreitler, E. Lazo, S. Myers, K. Qian, R. Schaffer, V. Shekar, W. Shi, A. Soares, V. Stojanoff, R. M. Sweet, L. Yang, S. McSweeney, Structural biology at the National Synchrotron Light Source II. J. Synch. Rad., 32, 873-883, PMCID: 40570041 (2025). [doi: 10.1107/S1600577525003194]

Elena V. Aleksandrova, Egor A. Syroegin, Ritwika S. Basu, Alexander A. Vassilevski, Matthieu G. Gagnon, Yury S. Polikanov, Elena V Aleksandrova, Egor A Syroegin, Ritwika S Basu, Alexander A Vassilevski, Matthieu G Gagnon, Yury S Polikanov, Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome.. Science (New York, N.Y.), 388(6753), eads9030-null, PMCID: 40536958 (2025). [doi: 10.1126/science.ads9030]

High ImpactStephen A. Rettie, Katelyn V. Campbell, Asim K. Bera, Alex Kang, Simon Kozlov, Yensi Flores Bueso, Joshmyn De La Cruz, Maggie Ahlrichs, Suna Cheng, Stacey R. Gerben, Mila Lamb, Analisa Murray, Victor Adebomi, Guangfeng Zhou, Frank DiMaio, Sergey Ovchinnikov, Gaurav Bhardwaj, Stephen A. Rettie, Katelyn V. Campbell, Asim K. Bera, Alex Kang, Simon Kozlov, Yensi Flores Bueso, Joshmyn de la Cruz, Maggie Ahlrichs, Suna Cheng, Stacey R. Gerben, Mila Lamb, Analisa Murray, Victor Adebomi, Guangfeng Zhou, Frank DiMaio, Sergey Ovchinnikov, Gaurav Bhardwaj, Cyclic peptide structure prediction and design using AlphaFold2. Nat. Comm., 16(1), 4730, PMCID: 40399308 (2025). [doi: 10.1038/s41467-025-59940-7]

High ImpactJoel M. J. Tan, Sarah Melamed, Joshua C. Cofsky, Deepsing Syangtan, Samuel J. Hobbs, Josefina del Mármol, Marco Jost, Andrew C. Kruse, Rotem Sorek, Philip J. Kranzusch, Joel M. J. Tan, Sarah Melamed, Joshua C. Cofsky, Deepsing Syangtan, Samuel J. Hobbs, Josefina del Marmol, Marco Jost, Andrew C. Kruse, Rotem Sorek, Philip J. Kranzusch, A DNA-gated molecular guard controls bacterial Hailong anti-phage defence. Nature, 643(8072), 794-800 (2025). [doi: 10.1038/s41586-025-09058-z]

High ImpactHaijiao Liu, Max Henderson, Zhili Pang, Qingfang Zhang, Eric Lam, Qun Liu, Haijiao Liu, Max Henderson, Zhili Pang, Qingfang Zhang, Eric Lam, Qun Liu, Structural determinants for pH-dependent activation of a plant metacaspase. Nat. Comm., 16(1), 4973, PMCID: 40442124 (2025). [doi: 10.1038/s41467-025-60253-y]

High ImpactGrace Neilsen, Shuiyun Lan, Ryan L. Slack, Zachary C. Lorson, Andres Emanuelli Castaner, Rachel Lee, Kristin G. Edwards, Huanchun Zhang, Jasper Lee, William A. Cantara, Maria E. Cilento, Hongwang Zhang, Ramyani De, Franck Amblard, Philip R. Tedbury, Karen A. Kirby, Raymond F. Schinazi, Stefan G. Sarafianos, Grace Neilsen, Shuiyun Lan, Ryan L. Slack, Zachary C. Lorson, Andres Emanuelli Castaner, Rachel Lee, Kristin G. Edwards, Huanchun Zhang, Jasper Lee, William A. Cantara, Maria E. Cilento, Hongwang Zhang, Ramyani De, Franck Amblard, Philip R. Tedbury, Karen A. Kirby, Raymond F. Schinazi, Stefan G. Sarafianos, Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease. Sci. Adv., 11(23), eadv8875, PMCID: 40479048 (2025). [doi: 10.1126/sciadv.adv8875]

High ImpactOlga Rechkoblit, Daniela Sciaky, Mi Ni, Yangmei Li, Jithesh Kottur, Gang Fang, Aneel K. Aggarwal, Olga Rechkoblit, Daniela Sciaky, Mi Ni, Yangmei Li, Jithesh Kottur, Gang Fang, Aneel K. Aggarwal, Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector. Nat. Comm., 16(1), 5243, PMCID: 40473611 (2025). [doi: 10.1038/s41467-025-60484-z]

High ImpactCited 1 timeSarah S. Hirschbeck, Michael R. Sawaya, Edward T. Lindberg, Miranda N. Limbach, Joshua H. Jang, Kristi L. Lazar Cantrell, David S. Eisenberg, Thanh D. Do, Sarah S. Hirschbeck, Michael R. Sawaya, Edward T. Lindberg, Miranda N. Limbach, Joshua H. Jang, Kristi L. Lazar Cantrell, David S. Eisenberg, Thanh D. Do, Amyloid Oligomers: Expediting Crystal Growth and Revisiting the Corkscrew Structures. J. Am. Chem. Soc., 147(22), 18594-18605, PMCID: 40398050 (2025). [doi: 10.1021/jacs.5c00656]

Cited 1 timeDanielle Swingle, Leah Epstein, Ramisha Aymon, Eta A. Isiorho, Rinat R. Abzalimov, Denize C. Favaro, Kevin H. Gardner, Variations in kinase and effector signaling logic in a bacterial two component signaling network. J. Biol. Chem., 301(6), 108534 (2025). [doi: 10.1016/j.jbc.2025.108534]

John A. Indergaard, Kashfia Mahmood, Leo Gabriel, Gary Zhong, Adam Lastovka, Matthew J. McLeod, Robert E. Thorne, Instrumentation and methods for efficient time-resolved X-ray crystallography of biomolecular systems with sub-10 ms time resolution. IUCrJ, 12(3), 372-383 (2025). [doi: 10.1107/S205225252500288X]

Cited 2 timesTong Gao, Nicholas A. Maskalenko, Salvin Kabir, Kerry S. Campbell, Jinhua Wu, Molecular basis of β2 integrin activation by talin unveils subunit-specific mechanisms of integrin signaling. Cell Rep., 44(5), 115607 (2025). [doi: 10.1016/j.celrep.2025.115607]

High ImpactCited 4 timesShagun Srivastava, Giridhar Sekar, Adedolapo Ojoawo, Anup Aggarwal, Elisabeth Ferreira, Emiko Uchikawa, Meek Yang, Christy R. Grace, Raja Dey, Yi-Lun Lin, Cristina D. Guibao, Seetharaman Jayaraman, Somnath Mukherjee, Anthony A. Kossiakoff, Bin Dong, Alexander Myasnikov, Tudor Moldoveanu, Structural basis of BAK sequestration by MCL-1 in apoptosis. Mol. Cell, 85(8), 1606-1623.e10 (2025). [doi: 10.1016/j.molcel.2025.03.013]

Cited 1 timeTrevor R. Melkonian, Nemanja Vuksanovic, Maria D. Person, Tzu-Yu Chen, Wei-chen Chang, Karen N. Allen, Christian P. Whitman, Beyond the β–α–β Fold: Characterization of a SnoaL Domain in the Tautomerase Superfamily. Biochemistry, 64(9), 1950-1962 (2025). [doi: 10.1021/acs.biochem.5c00051]

High ImpactCited 2 timesJingheng Wang, Stanley Nithianantham, Sergio C. Chai, Young-Hwan Jung, Lei Yang, Han Wee Ong, Yong Li, Yifan Zhang, Darcie J. Miller, Taosheng Chen, Decoding the selective chemical modulation of CYP3A4. Nat. Comm., 16(1), 3423 (2025). [doi: 10.1038/s41467-025-58749-8]

Michael R. Rankin, Dheeraj Khare, Lena Gerwick, David H. Sherman, William H. Gerwick, Janet L. Smith, Structure of a putative terminal amidation domain in natural product biosynthesis. Structure, 33(5), 935-947.e4 (2025). [doi: 10.1016/j.str.2025.02.005]

High ImpactCited 3 timesDivyansh Prakash, Suchitra Mitra, Simran Sony, Morgan Murphy, Babak Andi, Landon Ashley, Pallavi Prasad, Saumen Chakraborty, Controlling outer-sphere solvent reorganization energy to turn on or off the function of artificial metalloenzymes. Nat. Comm., 16(1), 3048 (2025). [doi: 10.1038/s41467-025-57904-5]

Cited 1 timeAmy E. Kennedy, Adam H. Barczewski, Christina R. Arnoldy, J. Pepper Pennington, Kelly A. Tiernan, M. Beatriz Hidalgo, Caroline C. Reilly, Tanyawan Wongsri, Michael J. Ragusa, Gevorg Grigoryan, Dale F. Mierke, Maria Pellegrini, The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition. Structure, 33(4), 691-704.e6 (2025). [doi: 10.1016/j.str.2025.01.010]

Cited 2 timesVincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer, Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease. Viruses, 17(1), 75 (2025). [doi: 10.3390/v17010075]

High ImpactCited 5 timesXugen Chen, Pan Fu, Karol Woloszyn, Yuemeng Zhang, Huanhuan Hu, Likai Hou, Xiaoyu Li, Jia Liu, Wenting Jiang, Lebing Wang, Simon Vecchioni, Yoel P. Ohayon, Ruojie Sha, Jianping Zheng, Feng Zhou, Precision Self-assembly of 3D DNA Crystals Using Microfluidics. J. Am. Chem. Soc., 147(14), 11915-11924 (2025). [doi: 10.1021/jacs.4c17455]

High ImpactCited 8 timesCherrelle Dacon, Re’em Moskovitz, Kristian Swearingen, Lais Da Silva Pereira, Yevel Flores-Garcia, Maya Aleshnick, Sachie Kanatani, Barbara Flynn, Alvaro Molina-Cruz, Kurt Wollenberg, Maria Traver, Payton Kirtley, Lauren Purser, Marlon Dillon, Brian Bonilla, Adriano Franco, Samantha Petros, Jake Kritzberg, Courtney Tucker, Gonzalo Gonzalez Paez, Priya Gupta, Melanie J. Shears, Joseph Pazzi, Joshua M. Edgar, Andy A. Teng, Arnel Belmonte, Kyosuke Oda, Safiatou Doumbo, Ludmila Krymskaya, Jeff Skinner, Shanping Li, Suman Ghosal, Kassoum Kayentao, Aissata Ongoiba, Ashley Vaughan, Joseph J. Campo, Boubacar Traore, Carolina Barillas-Mury, Wathsala Wijayalath, Azza Idris, Peter D. Crompton, Photini Sinnis, Brandon K. Wilder, Fidel Zavala, Robert A. Seder, Ian A. Wilson, Joshua Tan, Cherrelle Dacon, Re'em Moskovitz, Kristian Swearingen, Lais Da Silva Pereira, Yevel Flores-Garcia, Maya Aleshnick, Sachie Kanatani, Barbara Flynn, Alvaro Molina-Cruz, Kurt Wollenberg, Maria Traver, Payton Kirtley, Lauren Purser, Marlon Dillon, Brian Bonilla, Adriano Franco, Samantha Petros, Jake Kritzberg, Courtney Tucker, Gonzalo Gonzalez Paez, Priya Gupta, Melanie J. Shears, Joseph Pazzi, Joshua M. Edgar, Andy A. Teng, Arnel Belmonte, Kyosuke Oda, Safiatou Doumbo, Ludmila Krymskaya, Jeff Skinner, Shanping Li, Suman Ghosal, Kassoum Kayentao, Aissata Ongoiba, Ashley Vaughan, Joseph J. Campo, Boubacar Traore, Carolina Barillas-Mury, Wathsala Wijayalath, Azza Idris, Peter D. Crompton, Photini Sinnis, Brandon K. Wilder, Fidel Zavala, Robert A. Seder, Ian A. Wilson, Joshua Tan, Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein. Science, 387(6729), eadr0510, PMCID: 39745947 (2025). [doi: 10.1126/science.adr0510]

Roy J. Rodriguez Carrero, Cody T. Lloyd, Janhavi Borkar, Shounak Nath, Liviu M. Mirica, Satish Nair, Squire J. Booker, William Metcalf, Roy J. Rodriguez Carrero, Cody T. Lloyd, Janhavi Borkar, Shounak Nath, Liviu M. Mirica, Satish Nair, Squire J. Booker, William Metcalf, Genetic and biochemical characterization of a radical SAM enzyme required for post-translational glutamine methylation of methyl-coenzyme M reductase. mBio, 16(2), e03546-24 (2025). [doi: 10.1128/mbio.03546-24]

High ImpactCited 4 timesAmaruka Hazari, Michael R. Sawaya, Hyeonju Lee, Maria Sajimon, Hyungjun Kim, William A. Goddard III, David Eisenberg, Jevgenij A. Raskatov, Formation of rippled β-sheets from mixed chirality linear and cyclic peptides—new structural motifs based on the pauling-corey rippled β-sheet. Chem. Sci., 16(14), 5907-5917 (2025). [doi: 10.1039/d4sc08079c]

High ImpactCited 95 timesAnna Lauko, Samuel J. Pellock, Kiera H. Sumida, Ivan Anishchenko, David Juergens, Woody Ahern, Jihun Jeung, Andrew Hunt, Indrek Kalvet, Christoffer Norn, Ian R. Humphreys, Cooper Jamieson, Rohith Krishna, Yakov Kipnis, Alex Kang, Evans Brackenbrough, Asim K. Bera, Banumathi Sankaran, K. N. Houk, David Baker, Alexander F. Shida, Anna Lauko, Samuel J. Pellock, Kiera H. Sumida, Ivan Anishchenko, David Juergens, Woody Ahern, Jihun Jeung, Alexander F. Shida, Andrew Hunt, Indrek Kalvet, Christoffer Norn, Ian R. Humphreys, Cooper Jamieson, Rohith Krishna, Yakov Kipnis, Alex Kang, Evans Brackenbrough, Asim K. Bera, Banumathi Sankaran, K. N. Houk, David Baker, Computational design of serine hydrolases. Science, 388(6744), eadu2454, PMCID: 39946508 (2025). [doi: 10.1126/science.adu2454]

Cited 3 timesAnanya Paul, J. Ross Terrell, Abdelbasset A. Farahat, Edwin N. Ogbonna, Arvind Kumar, David W. Boykin, Stephen Neidle, W. David Wilson, Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence. ACS Chem. Biol., 20(2), 489-506 (2025). [doi: 10.1021/acschembio.4c00800]

Cited 5 timesArun K. Ghosh, Yueyi Chen, Ranjith Kumar Gadi, Amol Sonawane, Sandali Piladuwa Gamage, JohnJ.G. Tesmer, Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors. Eur. J. Med. Chem., 282, 117024 (2025). [doi: 10.1016/j.ejmech.2024.117024]

Cited 5 timesAndrew G. Wagner, Thomas B. D. Lang, Edward T. Ledingham, Agnidipta Ghosh, Donovan Brooks, Roozbeh Eskandari, Kajitha Suthagar, Steven C. Almo, Farah Lamiable-Oulaidi, Peter C. Tyler, Vern L. Schramm, Transition State Analogs of Human DNPH1 Reveal Two Electrophile Migration Mechanisms. J. Med. Chem., 68(3), 3653-3672 (2025). [doi: 10.1021/acs.jmedchem.4c02778]

High ImpactCited 5 timesHengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell, Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat. Comm., 16(1), 152 (2025). [doi: 10.1038/s41467-024-55421-5]

Florian Wittlinger, Surbhi P. Chitnis, Calvin D. Pham, Tahereh Damghani, Kishan B. Patel, Mareike Moellers, Ilse K. Schaeffner, Omobolanle A. Abidakun, Matthew Q. Deng, Blessing C. Ogboo, Alexander Rasch, Tyler S. Beyett, Brian Buckley, Frederic Feru, Tatiana Shaurova, Cornelius Knappe, Michael J. Eck, Pamela A. Hershberger, David A. Scott, Asher L. Brandt, Stefan A. Laufer, David E. Heppner, Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors. J. Med. Chem., 67(23), 21438-21469, PMCID: 39626019 (2024). [doi: 10.1021/acs.jmedchem.4c02311]

Matthew N. Gaynes, Kristin R. Osika, David W. Christianson, Structure and Function of Sabinene Synthase, a Monoterpene Cyclase That Generates a Highly Strained [3.1.0] Bicyclic Product. Biochemistry, 63(23), 3147-3159, PMCID: 39527408 (2024). [doi: 10.1021/acs.biochem.4c00476]

High Impact Haotian Du, Leena Mallik, Daniel Hwang, Yi Sun, Chengzi Kaku, Daniel Hoces, Shirley M. Sun, Reem Ghinnagow, Stephen D. Carro, Hoang Anh T. Phan, Sagar Gupta, Wyatt Blackson, Hyejin Lee, Christian A. Choe, Devin Dersh, Jingjia Liu, Braxton Bell, Hongli Yang, Georgia F. Papadaki, Michael C. Young, Emily Zhou, Gina El Nesr, Kimia Dasteh Goli, Laurence C. Eisenlohr, Andy J. Minn, Rogelio A. Hernandez-Lopez, Joseph G. Jardine, Nikolaos G. Sgourakis, Po-Ssu Huang, Targeting peptide antigens using a multiallelic MHC I-binding system. Nat. Biotechnol., 43(10), PMCID: 39672954 (2024). [doi: 10.1038/s41587-024-02505-8]

Zachary Geeraerts, Izumi Ishigami, Ariel Lewis-Ballester, Khoa N. Pham, Arina Kozlova, Caroline Mathieu, Raphael Frederick, Syun-Ru Yeh, Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase. J. Med. Chem., 67(16), 14543-14552, PMCID: 39106326 (2024). [doi: 10.1021/acs.jmedchem.4c01360]

Andria V. Rodrigues, Nigel W. Moriarty, Ramu Kakumanu, Andy DeGiovanni, Jose Henrique Pereira, Jennifer W. Gin, Yan Chen, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Characterization of lignin-degrading enzyme PmdC, which catalyzes a key step in the synthesis of polymer precursor 2-pyrone-4,6-dicarboxylic acid. The Journal of biological chemistry, 300(10), 107736, PMCID: 39222681 (2024). [doi: 10.1016/j.jbc.2024.107736]

Nicolas Grosjean, Lifang Zhang, Desigan Kumaran, Meng Xie, Audrey Fahey, Kassandra Santiago, Fangle Hu, Michael Regulski, Ian K. Blaby, Doreen Ware, Crysten E. Blaby-Haas, Functional diversification within the heme-binding split-barrel family. J. Biol. Chem., 300(11), 107888 (2024). [doi: 10.1016/j.jbc.2024.107888]

Cited 9 timesNian E. Zhou, Su Tang, Xuelin Bian, Maloy K. Parai, Inna V. Krieger, Armando Flores, Pradeep K. Jaiswal, Radha Bam, Jeremy L. Wood, Zhe Shi, Laura J. Stevens, Trevor Scobey, Meghan V. Diefenbacher, Fernando R. Moreira, Thomas J. Baric, Arjun Acharya, Joonyoung Shin, Manish M. Rathi, Karen C. Wolff, Laura Riva, Malina A. Bakowski, Case W. McNamara, Nicholas J. Catanzaro, Rachel L. Graham, David C. Schultz, Sara Cherry, Yoshihiro Kawaoka, Peter J. Halfmann, Ralph S. Baric, Mark R. Denison, Timothy P. Sheahan, James C. Sacchettini, An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo. Cell Rep., 43(11), 114929 (2024). [doi: 10.1016/j.celrep.2024.114929]

High ImpactCited 9 timesJameson R Averill, Jackson C Lin, John Jung, Hunmin Jung, Novel insights into the role of translesion synthesis polymerase in DNA incorporation and bypass of 5-fluorouracil in colorectal cancer. Nucleic Acids Res., 52(8), 4295-4312 (2024). [doi: 10.1093/nar/gkae102]

Cited 2 timesOren L. Lederberg, Nicholas L. Yan, Julian Sanchez, Wen Ren, Carl Ash, Steven J. Wilkens, Huang Qiu, Bo Qin, Virginia H. Grant, Alex B. Jackman, Robyn L. Stanfield, Ian A. Wilson, H. Michael Petrassi, Derek Rhoades, Jeffery W. Kelly, Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains. J. Med. Chem., 67(23), 21070-21105 (2024). [doi: 10.1021/acs.jmedchem.4c01773]

Cited 5 timesBo Wang, Amy E. Solinski, Matthew I. Radle, Olivia M. Peduzzi, Hayley L. Knox, Jiayuan Cui, Ravi K. Maurya, Neela H. Yennawar, Squire J. Booker, Structural Evidence for DUF512 as a Radical S-Adenosylmethionine Cobalamin-Binding Domain. ACS Bio Med Chem Au, 4(6), 319-330 (2024). [doi: 10.1021/acsbiomedchemau.4c00067]

High ImpactCited 82 timesTing-Hui Lin, Xueyong Zhu, Shengyang Wang, Ding Zhang, Ryan McBride, Wenli Yu, Simeon Babarinde, James C. Paulson, Ian A. Wilson, A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors. Science, 386(6726), 1128-1134 (2024). [doi: 10.1126/science.adt0180]

High ImpactSidney Lyayuga Lisanza, Jacob Merle Gershon, Samuel W. K. Tipps, Jeremiah Nelson Sims, Lucas Arnoldt, Samuel J. Hendel, Miriam K. Simma, Ge Liu, Muna Yase, Hongwei Wu, Claire D. Tharp, Xinting Li, Alex Kang, Evans Brackenbrough, Asim K. Bera, Stacey Gerben, Bruce J. Wittmann, Andrew C. McShan, David Baker, Sidney Lyayuga Lisanza, Jacob Merle Gershon, Samuel W. K. Tipps, Jeremiah Nelson Sims, Lucas Arnoldt, Samuel J. Hendel, Miriam K. Simma, Ge Liu, Muna Yase, Hongwei Wu, Claire D. Tharp, Xinting Li, Alex Kang, Evans Brackenbrough, Asim K. Bera, Stacey Gerben, Bruce J. Wittmann, Andrew C. McShan, David Baker, Multistate and functional protein design using RoseTTAFold sequence space diffusion. Nat. Biotechnol., 43(8), PMCID: 39322764 (2024). [doi: 10.1038/S41587-024-02395-W]

Cited 9 timesWayne D. Harshbarger, Genevieve Holzapfel, Nishat Seraj, Sai Tian, Chelsy Chesterman, Zongming Fu, Yan Pan, Claire Harelson, Dongjun Peng, Ying Huang, Sumana Chandramouli, Enrico Malito, Matthew James Bottomley, James Williams, Structures of the Varicella Zoster Virus Glycoprotein E and Epitope Mapping of Vaccine-Elicited Antibodies. Vaccines, 12(10), 1111 (2024). [doi: 10.3390/VACCINES12101111]

High ImpactCited 6 timesPragati Ganatra, Daniel F. Wang, Vaibhav Ganatra, Viet Thuc Dang, Andy I. Nguyen, Diverse Proteomimetic Frameworks via Rational Design of π-Stacking Peptide Tectons. J. Am. Chem. Soc., 146(32), 22236-22246 (2024). [doi: 10.1021/JACS.4C03094]

Cited 9 timesAndrew D. Huber, Wenwei Lin, Shyaron Poudel, Darcie J. Miller, Taosheng Chen, PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network. Structure, 32(12), 2352-2363.e8 (2024). [doi: 10.1016/J.STR.2024.09.016]

Cited 1 timeRebecca K. Zawistowski, Brian R. Crane, Differential Responses in the Core, Active Site and Peripheral Regions of Cytochrome c Peroxidase to Extreme Pressure and Temperature. J. Mol. Biol., 436(22), 168799 (2024). [doi: 10.1016/J.JMB.2024.168799]

Cited 2 timesMark Lee, Kate Magante, Camilo Gómez-Garzón, Shelley M. Payne, Aaron T. Smith, Structural determinants of Vibrio cholerae FeoB nucleotide promiscuity. J. Biol. Chem., 300(9), 107663 (2024). [doi: 10.1016/J.JBC.2024.107663]

High ImpactCited 30 timesMatthias Glögl, Aditya Krishnakumar, Robert J. Ragotte, Inna Goreshnik, Brian Coventry, Asim K. Bera, Alex Kang, Emily Joyce, Green Ahn, Buwei Huang, Wei Yang, Wei Chen, Mariana Garcia Sanchez, Brian Koepnick, David Baker, Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists. Science, 386(6726), 1154-1161 (2024). [doi: 10.1126/SCIENCE.ADP1779]

High ImpactCited 1 timeSusu He, Noor M Taher, Adam R Simard, Kelli L Hvorecny, Michael J Ragusa, Christopher D Bahl, Alison B Hickman, Fred Dyda, Dean R Madden, Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa. Nucleic Acids Res., 52(20), 12727-12747 (2024). [doi: 10.1093/NAR/GKAE889]

High ImpactCited 12 timesChristian F. Baca, Puja Majumder, James H. Hickling, Linzhi Ye, Marianna Teplova, Sean F. Brady, Dinshaw J. Patel, Luciano A. Marraffini, The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity. Cell, 187(25), 7183-7195.e24 (2024). [doi: 10.1016/J.CELL.2024.10.002]

Cited 3 timesVincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer, Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance. Viruses, 16(9), 1419 (2024). [doi: 10.3390/v16091419]

Cited 11 timesWeiping Huang, Chetana Baliga, Elena V Aleksandrova, Gemma Atkinson, Yury S Polikanov, Nora Vázquez-Laslop, Alexander S Mankin, Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects. EMBO Rep., 25(11), 5194-5211 (2024). [doi: 10.1038/s44319-024-00277-5]

Cited 1 timeEdwin N. Ogbonna, J Ross Terrell, Ananya Paul, Abdelbasset A. Farahat, Gregory M. K. Poon, David W. Boykin, W. David Wilson, Single GC base pair recognition by a heterocyclic diamidine: structures, affinities, and dynamics. RSC Adv., 14(40), 29675-29682 (2024). [doi: 10.1039/d4ra05957c]

Cited 1 timeEmma H. Kelley, Jerzy Osipiuk, Malgorzata Korbas, Michael Endres, Alayna Bland, Victoria Ehrman, Andrzej Joachimiak, Kenneth W. Olsen, Daniel P. Becker, Emma H. Kelley, Jerzy Osipiuk, Malgorzata Korbas, Michael Endres, Alayna Bland, Victoria Ehrman, Andrzej Joachimiak, Kenneth W. Olsen, Daniel P. Becker, N^α-acetyl-L-ornithine deacetylase from Escherichia coli and a ninhydrin-based assay to enable inhibitor identification. Front. Chem., 12, 1415644, PMCID: 39055043 (2024). [doi: 10.3389/fchem.2024.1415644]

High ImpactCited 2 timesRichard Quintana-Feliciano, Jithesh Kottur, Mi Ni, Rikhia Ghosh, Leslie Salas-Estrada, Goran Ahlsen, Olga Rechkoblit, Lawrence Shapiro, Marta Filizola, Gang Fang, Aneel K. Aggarwal, Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation. Nat. Comm., 15(1), 7839 (2024). [doi: 10.1038/s41467-024-52130-x]

High ImpactCited 8 timesChris A. Brosey, Todd M. Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L. Hura, Darin E. Jones, John A. Tainer, Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nat. Chem. Biol., 20(9), 1199-1209 (2024). [doi: 10.1038/s41589-024-01609-1]

Cited 7 timesFraser G. Ferens, Cassandra C. Taber, Sarah Stuart, Mia Hubert, Daniel Tarade, Jeffrey E. Lee, Michael Ohh, Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome. Commun Biol, 7(1), 240 (2024). [doi: 10.1038/s42003-024-05904-4]

High ImpactCited 4 timesEduardo Stancanelli, Juno A. Krahn, Elizabeth Viverette, Robert Dutcher, Vijayakanth Pagadala, Mario J. Borgnia, Jian Liu, Lars C. Pedersen, Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida to Improve the Synthesis of Heparin. ACS Catal., 14(9), 6577-6588 (2024). [doi: 10.1021/acscatal.4c00677]

High ImpactCited 56 timesUmut Karakus, Ignacio Mena, Jithesh Kottur, Sara S. El Zahed, Rocío Seoane, Soner Yildiz, Leanne Chen, Magdalena Plancarte, LeAnn Lindsay, Rebecca Halpin, Timothy B. Stockwell, David E. Wentworth, Geert-Jan Boons, Florian Krammer, Silke Stertz, Walter Boyce, Robert P. de Vries, Aneel K. Aggarwal, Adolfo García-Sastre, H19 influenza A virus exhibits species-specific MHC class II receptor usage. Cell Host & Microbe, 32(7), 1089-1102.e10 (2024). [doi: 10.1016/j.chom.2024.05.018]

High ImpactCited 21 timesYi Liu, Sophie G. Bender, Damien Sorigue, Daniel J. Diaz, Andrew D. Ellington, Greg Mann, Simon Allmendinger, Todd K. Hyster, Asymmetric Synthesis of α-Chloroamides via Photoenzymatic Hydroalkylation of Olefins. J. Am. Chem. Soc., 146(11), 7191-7197 (2024). [doi: 10.1021/jacs.4c00927]

High ImpactCited 212 timesMatthew Holderfield, Bianca J. Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J. Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W. Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E. Knox, Jennifer E. Klomp, Jennifer Roth, Matthew Rees, Melissa Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J. Aguirre, Andrew M. Waters, Channing J. Der, Chiara Ambrogio, Zhengping Wang, Adrian L. Gill, Elena S. Koltun, Jacqueline A. M. Smith, David Wildes, Mallika Singh, Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature, 629(8013), 919-926 (2024). [doi: 10.1038/s41586-024-07205-6]

High ImpactCited 9 timesJithesh Kottur, Radhika Malik, Aneel K. Aggarwal, Nucleic acid mediated activation of a short prokaryotic Argonaute immune system. Nat. Comm., 15(1), 4852 (2024). [doi: 10.1038/S41467-024-49271-4]

Matthew P. Agdanowski, Roger Castells-Graells, Michael R. Sawaya, Duilio Cascio, Todd O. Yeates, Mark A. Arbing, X-ray crystal structure of a designed rigidified imaging scaffold in the ligand-free conformation. Acta Cryst Sect F, 80(5), 107-115 (2024). [doi: 10.1107/S2053230X2400414X]

Cited 2 timesAndrea O’Malley, Sahana Sankaran, Avery Carriuolo, Kriti Khatri, Krzysztof Kowal, Maksymilian Chruszcz, Structural homology of mite profilins to plant profilins is not indicative of allergic cross-reactivity, 405(6), 367-381 (2024). [doi: 10.1515/HSZ-2023-0366]

High ImpactCited 16 timesBenjamin Fram, Yang Su, Ian Truebridge, Adam J. Riesselman, John B. Ingraham, Alessandro Passera, Eve Napier, Nicole N. Thadani, Samuel Lim, Kristen Roberts, Gurleen Kaur, Michael A. Stiffler, Debora S. Marks, Christopher D. Bahl, Amir R. Khan, Chris Sander, Nicholas P. Gauthier, Simultaneous enhancement of multiple functional properties using evolution-informed protein design. Nat. Comm., 15(1), 5141 (2024). [doi: 10.1038/S41467-024-49119-X]

Hyejin Esther Shin, Chuxi Pan, David M. Curran, Thomas J. Bateman, Derrick H. Y. Chong, Dixon Ng, Megha Shah, Trevor F. Moraes, Hyejin Esther Shin, Chuxi Pan, David M. Curran, Thomas J. Bateman, Derrick H. Y. Chong, Dixon Ng, Megha Shah, Trevor F. Moraes, Prevalence of Slam-dependent hemophilins in Gram-negative bacteria. J. Bacteriol., 206(6), PMCID: 38814789 (2024). [doi: 10.1128/JB.00027-24]

High ImpactCited 7 timesAmrita Singh, Samantha Ottavi, Inna Krieger, Kyle Planck, Andrew Perkowski, Takushi Kaneko, Andrew M. Davis, Christine Suh, David Zhang, Laurent Goullieux, Alexander Alex, Christine Roubert, Mark Gardner, Marian Preston, Dave M. Smith, Yan Ling, Julia Roberts, Bastien Cautain, Anna Upton, Christopher B. Cooper, Natalya Serbina, Zaid Tanvir, John Mosior, Ouathek Ouerfelli, Guangli Yang, Ben S. Gold, Kyu Y. Rhee, James C. Sacchettini, Nader Fotouhi, Jeffrey Aubé, Carl Nathan, Amrita Singh, Samantha Ottavi, Inna Krieger, Kyle Planck, Andrew Perkowski, Takushi Kaneko, Andrew M. Davis, Christine Suh, David Zhang, Laurent Goullieux, Alexander Alex, Christine Roubert, Mark Gardner, Marian Preston, Dave M. Smith, Yan Ling, Julia Roberts, Bastien Cautain, Anna Upton, Christopher B. Cooper, Natalya Serbina, Zaid Tanvir, John Mosior, Ouathek Ouerfelli, Guangli Yang, Ben S. Gold, Kyu Y. Rhee, James C. Sacchettini, Nader Fotouhi, Jeffrey Aube, Carl Nathan, Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Sci. Adv., 10(11), eadj6406, PMCID: 38489355 (2024). [doi: 10.1126/SCIADV.ADJ6406]

High ImpactHeike Schönherr, Pelin Ayaz, Alexander M. Taylor, Jessica B. Casaletto, B. Barry Touré, Demetri T. Moustakas, Brandi M. Hudson, Roberto Valverde, Songping Zhao, Patrick J. O’Hearn, Lindsey Foster, Dina A. Sharon, Sam Garfinkle, Fabrizio Giordanetto, André Lescarbeau, Ravi Kurukulasuriya, Nastaran Gerami-Moayed, Dejan Maglic, Kamil Bruderek, Gaauri Naik, Hakan Gunaydin, Mary M. Mader, Alessandro A. Boezio, Thomas H. McLean, Rongfeng Chen, Yanxia Wang, David E. Shaw, James Watters, Donald A. Bergstrom, Heike Schonherr, Pelin Ayaz, Alexander M. Taylor, Jessica B. Casaletto, B. Barry Toure, Demetri T. Moustakas, Brandi M. Hudson, Roberto Valverde, Songping Zhao, Patrick J. O'Hearn, Lindsey Foster, Dina A. Sharon, Sam Garfinkle, Fabrizio Giordanetto, Andre Lescarbeau, Ravi Kurukulasuriya, Nastaran Gerami-Moayed, Dejan Maglic, Kamil Bruderek, Gaauri Naik, Hakan Gunaydin, Mary M. Mader, Alessandro A. Boezio, Thomas H. Mclean, Rongfeng Chen, Yanxia Wang, David E. Shaw, James Watters, Donald A. Bergstrom, Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small- molecule inhibitor of FGFR2. Proc Natl Acad Sci USA, 121(6), e2317756121 (2024). [doi: 10.1073/PNAS.2317756121]

Cited 18 timesFlorian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner, Brandon T. Oligny, Surbhi P. Chitnis, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel A. Urul, Tatiana Shaurova, Earl W. May, Erik M. Schaefer, Michael J. Eck, Pamela A. Hershberger, Antti Poso, Stefan A. Laufer, David E. Heppner, Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem, 7(1), 38 (2024). [doi: 10.1038/S42004-024-01108-3]

High ImpactCited 20 timesShuai Wu, Sandra B. Gabelli, Jungsan Sohn, The structural basis for 2′−5′/3′−5′-cGAMP synthesis by cGAS. Nat. Comm., 15(1), 4012 (2024). [doi: 10.1038/s41467-024-48365-3]

High ImpactCited 16 timesEfren Garcia-Maldonado, Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J. Miller, Jayaraman Seetharaman, Taosheng Chen, Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat. Comm., 15(1), 4054 (2024). [doi: 10.1038/s41467-024-48472-1]

Jun Wang, Enabling Research and Innovation by Industry at National Synchrotron Light Source-II. Synch. Rad. News, 37(2), 4-9 (2024). [doi: 10.1080/08940886.2024.2329038]

High ImpactCited 10 timesNicolas Grosjean, Estella F. Yee, Desigan Kumaran, Kriti Chopra, Macon Abernathy, Sandeep Biswas, James Byrnes, Dale F. Kreitler, Jan-Fang Cheng, Agnidipta Ghosh, Steven C. Almo, Masakazu Iwai, Krishna K. Niyogi, Himadri B. Pakrasi, Ritimukta Sarangi, Hubertus van Dam, Lin Yang, Ian K. Blaby, Crysten E. Blaby-Haas, A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria. Nat. Comm., 15(1), 3167 (2024). [doi: 10.1038/s41467-024-47486-z]

Cited 11 timesYi Lien, Jake C. Lachowicz, Aigera Mendauletova, Cynthia Zizola, Thacien Ngendahimana, Anastasiia Kostenko, Sandra S. Eaton, John A. Latham, Tyler L. Grove, Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases. ACS Chem. Biol., 19(2), 370-379 (2024). [doi: 10.1021/acschembio.3c00583]

High ImpactCited 15 timesJake C. Lachowicz, David Lennox-Hvenekilde, Nils Myling-Petersen, Bo Salomonsen, Gijs Verkleij, Carlos G. Acevedo-Rocha, Ben Caddell, Luisa S. Gronenberg, Steven C. Almo, Morten O. A. Sommer, Hans J. Genee, Tyler L. Grove, Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe–5S Cluster for Sulfur Insertion. J. Am. Chem. Soc., 146(3), 1860-1873 (2024). [doi: 10.1021/jacs.3c05481]

Cited 8 timesMd Ashraf-Uz-Zaman, Teck Khiang Chua, Xin Li, Yuan Yao, Bala Krishna Moku, Chandra Bhushan Mishra, Vasanthi Avadhanula, Pedro A. Piedra, Yongcheng Song, Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease. ACS Infect. Dis., 10(2), 715-731 (2024). [doi: 10.1021/acsinfecdis.3c00565]

Cited 1 timeYacoba V. T. Minnow, Vern L. Schramm, Steven C. Almo, Agnidipta Ghosh, Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity. Biochemistry, 62(21), 3116-3125 (2023). [doi: 10.1021/acs.biochem.3c00264]

High ImpactCited 70 timesStefan Gahbauer, Galen J. Correy, Marion Schuller, Matteo P. Ferla, Yagmur Umay Doruk, Moira Rachman, Taiasean Wu, Morgan Diolaiti, Siyi Wang, R. Jeffrey Neitz, Daren Fearon, Dmytro S. Radchenko, Yurii S. Moroz, John J. Irwin, Adam R. Renslo, Jenny C. Taylor, Jason E. Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K. Shoichet, James S. Fraser, Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proc Natl Acad Sci USA, 120(2) (2023). [doi: 10.1073/pnas.2212931120]

Cited 2 timesMohammad Arif Rahman, Manuel Becerra-Flores, Yury Patskovsky, Isabela Silva de Castro, Massimiliano Bissa, Shraddha Basu, Xiaoying Shen, LaTonya D. Williams, Sarkis Sarkis, Kombo F. N’guessan, Celia LaBranche, Georgia D. Tomaras, Pyone Pyone Aye, Ronald Veazey, Dominic Paquin-Proulx, Mangala Rao, Genoveffa Franchini, Timothy Cardozo, Cholera toxin B scaffolded, focused SIV V2 epitope elicits antibodies that influence the risk of SIVmac251 acquisition in macaques. Front. Immunol., 14 (2023). [doi: 10.3389/fimmu.2023.1139402]

Cited 9 timesEdwin N. Ogbonna, Ananya Paul, Abdelbasset A. Farahat, J. Ross Terrell, Ekaterina Mineva, Victor Ogbonna, David W Boykin, W. David Wilson, X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences. ACS Bio Med Chem Au, 3(4), 335-348 (2023). [doi: 10.1021/acsbiomedchemau.3c00002]

Cited 27 timesLaura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A. Tararina, Emilia Neuwirt, Arianna Colcerasa, Philipp König, Lara Toy, Talha Z. Yesiloglu, Sebastian Hilscher, Lena Gaitzsch, Niklas Papenkordt, Shiyang Zhai, Lin Zhang, Christophe Romier, Oliver Einsle, Wolfgang Sippl, Mike Schutkowski, Olaf Gross, Gerd Bendas, David W. Christianson, Finn K. Hansen, Manfred Jung, Matthias Schiedel, Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. J. Med. Chem., 66(21), 14787-14814 (2023). [doi: 10.1021/ACS.JMEDCHEM.3C01385]

Cited 9 timesParis R. Watson, Juana Goulart Stollmaier, David W. Christianson, Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism. J. Biol. Chem., 299(10), 105228 (2023). [doi: 10.1016/J.JBC.2023.105228]

Cited 3 timesParis R. Watson, David W. Christianson, Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii. Biochemistry, 62(18), 2689-2699 (2023). [doi: 10.1021/ACS.BIOCHEM.3C00288]

Cited 8 timesT. A. Alsenani, S. L. Viviani, K. M. Papp-Wallace, R. A. Bonomo, F. van den Akker, Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Ω loop-held deacylation water. Antimicrob. Agents Chemother., 67(10) (2023). [doi: 10.1128/AAC.00350-23]

Cited 10 timesAndrew R. Mack, Vijay Kumar, Magdalena A. Taracila, Maria F. Mojica, Margaret O'Shea, William Schinabeck, Galen Silver, Andrea M. Hujer, Krisztina M. Papp-Wallace, Shuang Chen, Shozeb Haider, Emilia Caselli, Fabio Prati, Focco van den Akker, Robert A. Bonomo, Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase. Antimicrob. Agents Chemother., 67(11) (2023). [doi: 10.1128/aac.00791-23]

High ImpactCited 6 timesChad R. Simmons, Alex Buchberger, Skylar J.W. Henry, Alexandra Novacek, Nour Eddine Fahmi, Tara MacCulloch, Nicholas Stephanopoulos, Hao Yan, Site-Specific Arrangement and Structure Determination of Minor Groove Binding Molecules in Self-Assembled Three-Dimensional DNA Crystals. J. Am. Chem. Soc., 145(48), 26075-26085 (2023). [doi: 10.1021/jacs.3c07802]

Olivia Ariane Awaté, Structure-Function Relationships in HpuAB, the Gonococcal Bipartite TonB- dependent Transport System, PhD Thesis. Georgia State University, Atlanta (2023).

High ImpactCited 11 timesAaron Gupta, Kevin S. Kao, Rachel Yamin, Deena A. Oren, Yehuda Goldgur, Jonathan Du, Pete Lollar, Eric J. Sundberg, Jeffrey V. Ravetch, Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody. Nat. Comm., 14(1), 2853 (2023). [doi: 10.1038/s41467-023-38453-1]

High ImpactCited 18 timesYury Patskovsky, Aswin Natarajan, Larysa Patskovska, Samantha Nyovanie, Bishnu Joshi, Benjamin Morin, Christine Brittsan, Olivia Huber, Samuel Gordon, Xavier Michelet, Florian Schmitzberger, Robert B. Stein, Mark A. Findeis, Andy Hurwitz, Marc Van Dijk, Eleni Chantzoura, Alvaro S. Yague, Daniel Pollack Smith, Jennifer S. Buell, Dennis Underwood, Michelle Krogsgaard, Molecular mechanism of phosphopeptide neoantigen immunogenicity. Nat. Comm., 14(1), 3763 (2023). [doi: 10.1038/s41467-023-39425-1]

High ImpactCited 21 timesKatharine M. Wright, Sarah R. DiNapoli, Michelle S. Miller, P. Aitana Azurmendi, Xiaowei Zhao, Zhiheng Yu, Mayukh Chakrabarti, WuXian Shi, Jacqueline Douglass, Michael S. Hwang, Emily Han-Chung Hsiue, Brian J. Mog, Alexander H. Pearlman, Suman Paul, Maximilian F. Konig, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli, Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen. Nat. Comm., 14(1), 5063 (2023). [doi: 10.1038/s41467-023-40821-w]

Cited 8 timesJithesh Kottur, Kris M. White, M. Luis Rodriguez, Olga Rechkoblit, Richard Quintana-Feliciano, Ahana Nayar, Adolfo García-Sastre, Aneel K. Aggarwal, Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals. Plos Pathog., 19(7), e1011546 (2023). [doi: 10.1371/journal.ppat.1011546]

Cited 2 timesAkira Karasawa, Haijiao Liu, Matthias Quick, Wayne A. Hendrickson, Qun Liu, Crystallographic Characterization of Sodium Ions in a Bacterial Leucine/Sodium Symporter. Crystals, 13(2), 183 (2023). [doi: 10.3390/cryst13020183]

Cited 11 timesAndrea Piserchio, Eta A. Isiorho, Kevin N. Dalby, Ranajeet Ghose, Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor. J. Biol. Chem., 299(6), 104813 (2023). [doi: 10.1016/j.jbc.2023.104813]

Cited 1 timeIda de Vries, Danique Ammerlaan, Tatjana Heidebrecht, Patrick HN Celie, Robbie P Joosten, Anastassis Perrakis, Daan P Geerke, Distant sequence regions of JBP1 contribute to J-DNA binding. Life Sci. Alliance, 6(9), e202302150 (2023). [doi: 10.26508/lsa.202302150]

Cited 6 timesSamuel A. Eaton, David W. Christianson, Reprogramming the Cyclization Cascade of epi-Isozizaene Synthase to Generate Alternative Terpene Products. Biochemistry, 62(15), 2301-2313 (2023). [doi: 10.1021/acs.biochem.3c00247]

High ImpactCited 6 timesFu-Lien Hsieh, Tao-Hsin Chang, Sandra B. Gabelli, Jeremy Nathans, Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein. Proc Natl Acad Sci USA, 120(20), e2217096120 (2023). [doi: 10.1073/pnas.2217096120]

Cited 9 timesJ. Ross Terrell, Samuel J. Taylor, Amelia L. Schneider, Yue Lu, Tyler N. Vernon, Suela Xhani, Ryan H. Gumpper, Ming Luo, W. David Wilson, Ulrich Steidl, Gregory M.K. Poon, DNA selection by the master transcription factor PU.1. Cell Rep., 42(7), 112671 (2023). [doi: 10.1016/j.celrep.2023.112671]

Cited 3 timesVijay Kumar, Jacob Boorman, William J. Greenlee, Ximin Zeng, Jun Lin, Focco van den Akker, Vijay Kumar, Jacob Boorman, William J. J. Greenlee, Ximin Zeng, Jun Lin, Focco van den Akker, Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds. Protein Sci., 32(7), e4683, PMCID: 37209283 (2023). [doi: 10.1002/pro.4683]

High ImpactCited 13 timesAndrea Piserchio, Kimberly J. Long, Luke S. Browning, Amanda L. Bohanon, Eta A. Isiorho, Kevin N. Dalby, Ranajeet Ghose, ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc Natl Acad Sci USA, 120(17), e2300902120 (2023). [doi: 10.1073/pnas.2300902120]

Cited 3 timesZachary J. Carter, Klarissa Hollander, Krasimir A. Spasov, Karen S. Anderson, William L. Jorgensen, Design, synthesis, and biological testing of biphenylmethyloxazole inhibitors targeting HIV-1 reverse transcriptase. BioOrg. Med. Chem., 84, 129216 (2023). [doi: 10.1016/j.bmcl.2023.129216]

Cited 13 timesYunfeng Li, Yulia Pustovalova, Wuxian Shi, Oksana Gorbatyuk, Sridhar Sreeramulu, Harald Schwalbe, Jeffrey C. Hoch, Bing Hao, Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3. Sci Rep, 13(1), 2890 (2023). [doi: 10.1038/s41598-023-30045-9]

High ImpactCited 17 timesWenwei Lin, Andrew D. Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen, Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein. Proc Natl Acad Sci USA, 120(10), e2217804120 (2023). [doi: 10.1073/pnas.2217804120]

Edwin Ogbonna, The Application of X-ray Crystallography for Structural Information on DNA-Amidine Complexes and Detailed Examination of Minor Groove Structures of B-DNA, Thesis Thesis. Georgia State University, Atlanta (2023).

Cited 7 timesSamantha N. Muellers, Margarita A. Tararina, Uros Kuzmanovic, James E. Galagan, Karen N. Allen, Structural Insights into the Substrate Range of a Bacterial Monoamine Oxidase. Biochemistry, 62(3), 851-862 (2023). [doi: 10.1021/acs.biochem.2c00540]

High ImpactCited 6 timesYuan Tian, Ishara Datta, Rui Yang, Chun Wan, Bing Wang, Lauren Crisman, Huan He, Chad A. Brautigam, Suzhao Li, Jingshi Shen, Qian Yin, Oligomer-to-monomer transition underlies the chaperone function of AAGAB in AP1/AP2 assembly. Proc Natl Acad Sci USA, 120(2), e2205199120 (2023). [doi: 10.1073/pnas.2205199120]

High ImpactCited 2 timesYunfeng Li, Yulia Pustovalova, Tzanko I. Doukov, Jeffrey C. Hoch, Richard E. Mains, Betty A. Eipper, Bing Hao, Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs. Nat. Comm., 14(1), 96 (2023). [doi: 10.1038/s41467-022-35678-4]

High ImpactCited 22 timesYiming Hu, Shaoda Huang, Lacey J. Wayment, Jingyi Wu, Qiucheng Xu, Tieyan Chang, Ying-Pin Chen, Xiaonian Li, Babak Andi, Hongxuan Chen, Yinghua Jin, Han Zhu, Mingliang Du, Shuanglong Lu, Wei Zhang, Shape-persistent phthalocyanine cages. Cell Reports Physical Science, 4(2), 101285 (2023). [doi: 10.1016/j.xcrp.2023.101285]

Cited 1 timeSeth P. Jones, Kali H. Cook, Melody L. Holmquist, Liam J. Almekinder, Annie M. Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E. Pichichero, Ravinder Kaur, Lea V. Michel, Michael L. Gleghorn, Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers. Proteins: Struc. Func. Genet., 91(2), 161-170 (2023). [doi: 10.1002/prot.26418]

High ImpactCited 36 timesDhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Shambhavi Bhagwat, Melissa Reimers, Eric H. Kim, Manish K. Thakur, Muhammad A. Saeed, Russell K. Pachynski, Markus A. Seeliger, W. Todd Miller, Felix Y. Feng, Nupam P. Mahajan, Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nat. Comm., 13(1), 6929 (2022). [doi: 10.1038/s41467-022-34724-5]

High ImpactCited 62 timesErica N. Parker, Brett N. Cain, Behnoush Hajian, Rebecca J. Ulrich, Emily J. Geddes, Sulyman Barkho, Hyang Yeon Lee, John D. Williams, Malik Raynor, Diana Caridha, Angela Zaino, Mrinal Shekhar, Kristen A. Muñoz, Kara M. Rzasa, Emily R. Temple, Diana Hunt, Xiannu Jin, Chau Vuong, Kristina Pannone, Aya M. Kelly, Michael P. Mulligan, Katie K. Lee, Gee W. Lau, Deborah T. Hung, Paul J. Hergenrother, An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections. ACS Central Sci., 8(8), 1145-1158 (2022). [doi: 10.1021/acscentsci.2c00598]

Cited 51 timesT. A. Alsenani, S. L. Viviani, V. Kumar, M. A. Taracila, C. R. Bethel, M. D. Barnes, K. M. Papp-Wallace, R. K. Shields, M. H. Nguyen, C. J. Clancy, R. A. Bonomo, F. van den Akker, Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob. Agents Chemother., 66(4) (2022). [doi: 10.1128/aac.02414-21]

High ImpactCited 71 timesTom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R. Shrestha, Rafal Wiewiora, Zachary A. McDargh, Fen Pei, Rajat Pal, João V. Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M. Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A. Izaguirre, Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry. Nat. Comm., 13(1), 5884 (2022). [doi: 10.1038/s41467-022-33575-4]

High ImpactCited 21 timesXiaodong Luan, Xinming Li, Yufan Li, Gengchen Su, Wanchao Yin, Yi Jiang, Ning Xu, Feng Wang, Wang Cheng, Ye Jin, Leike Zhang, H. Eric Xu, Yi Xue, Shuyang Zhang, Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein. Science Bulletin, 67(22), 2327-2335 (2022). [doi: 10.1016/j.scib.2022.10.021]

High ImpactCited 27 timesAlexander A. Peterson, Aziz M. Rangwala, Manish K. Thakur, Patrick S. Ward, Christie Hung, Ian R. Outhwaite, Alix I. Chan, Dmitry L. Usanov, Vamsi K. Mootha, Markus A. Seeliger, David R. Liu, Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat. Chem. Biol., 18(11), 1184-1195 (2022). [doi: 10.1038/s41589-022-01116-1]

High ImpactCited 17 timesKunhua Li, Olena S. Tokareva, Ty M. Thomson, Sebastian C. T. Wahl, Tara L. Travaline, Jessica D. Ramirez, Santosh K. Choudary, Sorabh Agarwal, Ward G. Walkup, Tivoli J. Olsen, Matthew J. Brennan, Gregory L. Verdine, John H. McGee, De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries. Proc Natl Acad Sci USA, 119(52) (2022). [doi: 10.1073/pnas.2210435119]

Cited 48 timesDavid E. Heppner, Florian Wittlinger, Tyler S. Beyett, Tatiana Shaurova, Daniel A. Urul, Brian Buckley, Calvin D. Pham, Ilse K. Schaeffner, Bo Yang, Blessing C. Ogboo, Earl W. May, Erik M. Schaefer, Michael J. Eck, Stefan A. Laufer, Pamela A. Hershberger, Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448). ACS Med. Chem. Lett., 13(12), 1856-1863 (2022). [doi: 10.1021/acsmedchemlett.2c00213]

High ImpactCited 9 timesLu Gan, Kiyoul Park, Jin Chai, Evan M. Updike, Hyojin Kim, Adam Voshall, Sairam Behera, Xiao-Hong Yu, Yuanheng Cai, Chunyu Zhang, Mark A. Wilson, Jeffrey P. Mower, Etsuko N. Moriyama, Chi Zhang, Sireewan Kaewsuwan, Qun Liu, John Shanklin, Edgar B. Cahoon, Divergent evolution of extreme production of variant plant monounsaturated fatty acids. Proc Natl Acad Sci USA, 119(30) (2022). [doi: 10.1073/pnas.2201160119]

Cited 21 timesKuan‐Lin Wu, Joshua A. Moore, Mitchell D. Miller, Yuda Chen, Catherine Lee, Weijun Xu, Zane Peng, Qinghui Duan, George N. Phillips, Rosa A. Uribe, Han Xiao, Expanding the eukaryotic genetic code with a biosynthesized 21st amino acid. Protein Sci., 31(10) (2022). [doi: 10.1002/pro.4443]

Cited 4 timesAkira Karasawa, Babak Andi, Martin R. Fuchs, Wuxian Shi, Sean McSweeney, Wayne A. Hendrickson, Qun Liu, Multi-crystal native-SAD phasing at 5 keV with a helium environment. IUCrJ, 9(6), 768-777 (2022). [doi: 10.1107/S205225252200971X]

Cited 8 timesJoão Leandro, Susmita Khamrui, Chalada Suebsuwong, Peng-Jen Chen, Cody Secor, Tetyana Dodatko, Chunli Yu, Roberto Sanchez, Robert J. DeVita, Sander M. Houten, Michael B. Lazarus, Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1. Open Biol., 12(9) (2022). [doi: 10.1098/rsob.220179]

High ImpactCited 27 timesJithesh Kottur, Olga Rechkoblit, Richard Quintana-Feliciano, Daniela Sciaky, Aneel K. Aggarwal, High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development. Nat Struct Mol Biol, 29(9), 850-853 (2022). [doi: 10.1038/s41594-022-00828-1]

Colin Sheehan, New Perspectives on a Pseudomonas aeruginosa Virulence Pathway Affecting Ubiquitination and Protein Homeostasis, Dissertation Thesis. Dartmouth College (2022).

Arnold Savenije, Obtaining diffuse scattering signal from X-ray diffraction experiments on lysozyme, Dissertation Thesis. Utrecht University (2022).

Nicholas York, The role of outer-sphere residues and substrate-binding at the 3-mercaptopropionic acid dioxygenase (3mdo) active site: a combined spectroscopic and computational investigation, Dissertation Thesis. University of Alabama (2022).

Noor Taher, New Twists on Familiar Motifs: Structural and Enzymatic Characterization of Two Cif-Like Epoxide Hydrolases from the Opportunistic Pathogen Burkholderia cenocepacia, Dissertation Thesis. Dartmouth College (2022).

Valerie Khayyo, Structural and Functional Insight into the Lipin Family of Phosphatidic Acid Phosphatases, Dissertation Thesis. Stony Brook University, Stony Brook (2022).

High ImpactCited 40 timesMeredith J. Zeller, Oleg Favorov, Kelin Li, Ashok Nuthanakanti, Dina Hussein, Auréliane Michaud, Daniel A. Lafontaine, Steven Busan, Alexander Serganov, Jeffrey Aubé, Kevin M. Weeks, SHAPE-enabled fragment-based ligand discovery for RNA. Proc Natl Acad Sci USA, 119(20) (2022). [doi: 10.1073/pnas.2122660119]

Cited 1 timeWilliam D. Tolbert, Dung N. Nguyen, Marina Tuyishime, Andrew R. Crowley, Yaozong Chen, Shalini Jha, Derrick Goodman, Valerie Bekker, Sarah V. Mudrak, Anthony L. DeVico, George K. Lewis, James F. Theis, Abraham Pinter, M. Anthony Moody, David Easterhoff, Kevin Wiehe, Justin Pollara, Kevin O. Saunders, Georgia D. Tomaras, Margaret Ackerman, Guido Ferrari, Marzena Pazgier, Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s. Front. Immunol., 12 (2022). [doi: 10.3389/fimmu.2021.787603]

High ImpactCited 28 timesTimothy R. Stachowski, Murugendra Vanarotti, Jayaraman Seetharaman, Karlo Lopez, Marcus Fischer, Water Networks Repopulate Protein–Ligand Interfaces with Temperature. Angew. Chem. Int. Ed., 61(31) (2022). [doi: 10.1002/anie.202112919]

High ImpactCited 19 timesLeah C. Spangler, Mina Yu, Philip D. Jeffrey, Gregory D. Scholes, Controllable Phycobilin Modification: An Alternative Photoacclimation Response in Cryptophyte Algae. ACS Central Sci., 8(3), 340-350 (2022). [doi: 10.1021/acscentsci.1c01209]

High ImpactCited 30 timesGeetika Singh, Cristina D. Guibao, Jayaraman Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, M. Brett Waddell, Tudor Moldoveanu, Structural basis of BAK activation in mitochondrial apoptosis initiation. Nat. Comm., 13(1), 250 (2022). [doi: 10.1038/s41467-021-27851-y]

Cited 12 timesChristopher D. Radka, Darcie J. Miller, Matthew W. Frank, Charles O. Rock, Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii. J. Biol. Chem., 298(8), 102195 (2022). [doi: 10.1016/j.jbc.2022.102195]

Cited 1 timeTung-Chung Mou, Baisen Zeng, Tzanko I. Doukov, Stephen R. Sprang, Application of sulfur SAD to small crystals with a large asymmetric unit and anomalous substructure. Acta Cryst Sect D Struct Biol, 78(8), 1021-1031 (2022). [doi: 10.1107/S2059798322005848]

High ImpactCited 10 timesJin Du, Michael Estrella, Kristina Solorio-Kirpichyan, Philip D. Jeffrey, Alexei Korennykh, Structure of human NADK2 reveals atypical assembly and regulation of NAD kinases from animal mitochondria. Proc Natl Acad Sci USA, 119(26) (2022). [doi: 10.1073/pnas.2200923119]

Cited 33 timesAli Ebrahim, Blake T. Riley, Desigan Kumaran, Babak Andi, Martin R. Fuchs, Sean McSweeney, Daniel A. Keedy, The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M<sup>pro</sup>). IUCrJ, 9(5), 682-694 (2022). [doi: 10.1107/s2052252522007497]

Cited 19 timesMeredith J. Zeller, Ashok Nuthanakanti, Kelin Li, Jeffrey Aubé, Alexander Serganov, Kevin M. Weeks, Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery. ACS Chem. Biol., 17(2), 438-448 (2022). [doi: 10.1021/acschembio.1c00880]

Cited 9 timesLakshmi Srinivasan, Vanina Alzogaray, Dakshnamurthy Selvakumar, Sara Nathan, Jesse B. Yoder, Katharine M. Wright, Sebastián Klinke, Justin N. Nwafor, María S. Labanda, Fernando A. Goldbaum, Arne Schön, Ernesto Freire, Gordon F. Tomaselli, L. Mario Amzel, Manu Ben-Johny, Sandra B. Gabelli, Development of high-affinity nanobodies specific for NaV1.4 and NaV1.5 voltage-gated sodium channel isoforms. J. Biol. Chem., 298(4), 101763 (2022). [doi: 10.1016/j.jbc.2022.101763]

High ImpactCited 38 timesChad R. Simmons, Tara MacCulloch, Miroslav Krepl, Michael Matthies, Alex Buchberger, Ilyssa Crawford, Jiří Šponer, Petr Šulc, Nicholas Stephanopoulos, Hao Yan, The influence of Holliday junction sequence and dynamics on DNA crystal self-assembly. Nat. Comm., 13(1), 3112 (2022). [doi: 10.1038/s41467-022-30779-6]

Cited 4 timesRicha Arya, Zachary Maben, Digamber Rane, Akbar Ali, Lawrence J. Stern, Phenylsulfamoyl Benzoic Acid Inhibitor of ERAP2 with a Novel Mode of Inhibition. ACS Chem. Biol., 17(7), 1756-1768 (2022). [doi: 10.1021/acschembio.2c00093]

Cited 40 timesBabak Andi, Desigan Kumaran, Dale F. Kreitler, Alexei S. Soares, Jantana Keereetaweep, Jean Jakoncic, Edwin O. Lazo, Wuxian Shi, Martin R. Fuchs, Robert M. Sweet, John Shanklin, Paul D. Adams, Jurgen G. Schmidt, Martha S. Head, Sean McSweeney, Hepatitis C virus NS3/4A inhibitors and other drug-like compounds as covalent binders of SARS-CoV-2 main protease. Sci Rep, 12(1), 12197 (2022). [doi: 10.1038/s41598-022-15930-z]

High ImpactCited 89 timesAla M. Shaqra, Sarah N. Zvornicanin, Qiu Yu J. Huang, Gordon J. Lockbaum, Mark Knapp, Laura Tandeske, David T. Bakan, Julia Flynn, Daniel N. A. Bolon, Stephanie Moquin, Dustin Dovala, Nese Kurt Yilmaz, Celia A. Schiffer, Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat. Comm., 13(1), 3556 (2022). [doi: 10.1038/s41467-022-31210-w]

Cited 6 timesThu Nguyen, Kim L. Phan, Dima Kozakov, Sandra B. Gabelli, Dale F. Kreitler, Lawrence C. Andrews, Jean Jakoncic, Robert M. Sweet, Alexei S. Soares, Herbert J. Bernstein, A simple technique to classify diffraction data from dynamic proteins according to individual polymorphs. Acta Cryst Sect D Struct Biol, 78(3), 268-277 (2022). [doi: 10.1107/S2059798321013425]

Cited 20 timesChristopher L. Sander, Jennings Luu, Kyumhyuk Kim, David Furkert, Kiyoung Jang, Joerg Reichenwallner, MinSoung Kang, Ho-Jun Lee, Bryan T. Eger, Hui-Woog Choe, Dorothea Fiedler, Oliver P. Ernst, Yong Ju Kim, Krzysztof Palczewski, Philip D. Kiser, Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure, 30(2), 263-277.e5 (2022). [doi: 10.1016/j.str.2021.10.002]

High ImpactCited 16 timesNivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V. Airola, Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents. Nat. Comm., 12(1), 5885 (2021). [doi: 10.1038/s41467-021-26163-5]

Cited 13 timesLawrence Chai, Ping Zhu, Jin Chai, Changxu Pang, Babak Andi, Sean McSweeney, John Shanklin, Qun Liu, AlphaFold Protein Structure Database for Sequence-Independent Molecular Replacement. Crystals, 11(10), 1227 (2021). [doi: 10.3390/cryst11101227]

High ImpactCited 37 timesDaniel R. Dempsey, Thibault Viennet, Reina Iwase, Eunyoung Park, Stephanie Henriquez, Zan Chen, Jeliazko R. Jeliazkov, Brad A. Palanski, Kim L. Phan, Paul Coote, Jeffrey J. Gray, Michael J. Eck, Sandra B. Gabelli, Haribabu Arthanari, Philip A. Cole, The structural basis of PTEN regulation by multi-site phosphorylation. Nat. Struct. Mol. Biol., 28(10), 858-868 (2021). [doi: 10.1038/s41594-021-00668-5]

High ImpactCited 103 timesXufen Yu, Dongxu Li, Jithesh Kottur, Yudao Shen, Huen Suk Kim, Kwang-Su Park, Yi-Hsuan Tsai, Weida Gong, Jun Wang, Kyogo Suzuki, Joel Parker, Laura Herring, H. Ümit Kaniskan, Ling Cai, Rinku Jain, Jing Liu, Aneel K Aggarwal, Gang Greg Wang, Jian Jin, A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci. Transl. Med., 13(613) (2021). [doi: 10.1126/scitranslmed.abj1578]

High ImpactCited 16 timesJingheng Wang, Cameron D. Buchman, Jayaraman Seetharaman, Darcie J. Miller, Andrew D. Huber, Jing Wu, Sergio C. Chai, Efren Garcia-Maldonado, William C. Wright, Jude Chenge, Taosheng Chen, Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5. J. Am. Chem. Soc., 143(44), 18467-18480 (2021). [doi: 10.1021/jacs.1c07066]

High ImpactCited 65 timesJared Balaich, Michael Estrella, Guojun Wu, Philip D. Jeffrey, Abhishek Biswas, Liping Zhao, Alexei Korennykh, Mohamed S. Donia, The human microbiome encodes resistance to the antidiabetic drug acarbose. Nature, 600(7887), 110-115 (2021). [doi: 10.1038/s41586-021-04091-0]

High ImpactCited 22 timesAshleigh S. Paparella, Briana L. Aboulache, Rajesh K. Harijan, Kathryn S. Potts, Peter C. Tyler, Vern L. Schramm, Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. Nat. Comm., 12(1), 6285 (2021). [doi: 10.1038/s41467-021-26580-6]

Cited 19 timesDieter Waschbüsch, Kerryn Berndsen, Pawel Lis, Axel Knebel, Yuko PY Lam, Dario R Alessi, Amir R Khan, Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. EMBO Rep., 22(11) (2021). [doi: 10.15252/embr.202152675]

High ImpactCited 28 timesZachary Maben, Richa Arya, Dimitris Georgiadis, Efstratios Stratikos, Lawrence J. Stern, Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism. Nat. Comm., 12(1), 5302 (2021). [doi: 10.1038/s41467-021-25564-w]

High ImpactCited 19 timesWeijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola, The middle lipin domain adopts a membrane-binding dimeric protein fold. Nat. Comm., 12(1), 4718 (2021). [doi: 10.1038/s41467-021-24929-5]

High ImpactCited 30 timesMichael S. Hwang, Michelle S. Miller, Puchong Thirawatananond, Jacqueline Douglass, Katharine M. Wright, Emily Han-Chung Hsiue, Brian J. Mog, Tihitina Y. Aytenfisu, Michael B. Murphy, P. Aitana Azurmendi, Andrew D. Skora, Alexander H. Pearlman, Suman Paul, Sarah R. DiNapoli, Maximilian F. Konig, Chetan Bettegowda, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli, Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens. Nat. Comm., 12(1), 5271 (2021). [doi: 10.1038/s41467-021-25605-4]

Cited 12 timesEdwin O. Lazo, Stephen Antonelli, Jun Aishima, Herbert J. Bernstein, Dileep Bhogadi, Martin R. Fuchs, Nicolas Guichard, Sean McSweeney, Stuart Myers, Kun Qian, Dieter Schneider, Grace Shea-McCarthy, John Skinner, Robert Sweet, Lin Yang, Jean Jakoncic, Robotic sample changers for macromolecular X-ray crystallography and biological small-angle X-ray scattering at the National Synchrotron Light Source II. J. Synch. Rad., 28(5), 1649-1661 (2021). [doi: 10.1107/S1600577521007578]

Cited 14 timesSai Priya Anand, Shilei Ding, William D. Tolbert, Jérémie Prévost, Jonathan Richard, Hwi Min Gil, Gabrielle Gendron-Lepage, Wing-Fai Cheung, Haifeng Wang, Rebecca Pastora, Hirak Saxena, Warren Wakarchuk, Halima Medjahed, Bruce D. Wines, Mark Hogarth, George M. Shaw, Malcom A. Martin, Dennis R. Burton, Lars Hangartner, David T. Evans, Marzena Pazgier, Doug Cossar, Michael D. McLean, Andrés Finzi, Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells. J. Virology, 95(18) (2021). [doi: 10.1128/JVI.00796-21]

High ImpactCited 199 timesKonstantin Shatalin, Ashok Nuthanakanti, Abhishek Kaushik, Dmitry Shishov, Alla Peselis, Ilya Shamovsky, Bibhusita Pani, Mirna Lechpammer, Nikita Vasilyev, Elena Shatalina, Dmitri Rebatchouk, Alexander Mironov, Peter Fedichev, Alexander Serganov, Evgeny Nudler, Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance. Science, 372(6547), 1169-1175 (2021). [doi: 10.1126/science.abd8377]

Cited 15 timesEliav Blum, Jianye Zhang, Jordan Zaluski, David E. Einstein, Edward E. Korshin, Adam Kubas, Arie Gruzman, Gregory P. Tochtrop, Philip D. Kiser, Krzysztof Palczewski, Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J. Med. Chem., 64(12), 8287-8302 (2021). [doi: 10.1021/acs.jmedchem.1c00279]

Cited 24 timesJake C. Lachowicz, Anthony S. Gizzi, Steven C. Almo, Tyler L. Grove, Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life. Biochemistry, 60(26), 2116-2129 (2021). [doi: 10.1021/acs.biochem.0c00958]

Cited 17 timesCharles R. Midgett, Kacey Marie Talbot, Jessica L. Day, George P. Munson, F. Jon Kull, Structure of the master regulator Rns reveals an inhibitor of enterotoxigenic Escherichia coli virulence regulons. Sci Rep, 11(1), 15663 (2021). [doi: 10.1038/s41598-021-95123-2]

Lucinda Hemmick, Dame Forbes, Robert Bolen, Mary Kroll, Dianna Gobler, John Halloran, Vivian Stojanoff, Aleida Perez, Collaboration Crushes Competition! Preparing High School Research Students for Success in Big Science Careers. The Science Teacher, 88(6), 38 (2021).

Cited 6 timesVijay Kumar, Snigdha A. Mathure, Mijoon Lee, Jacob Boorman, Ximin Zeng, Jun Lin, Dusan Hesek, Elena Lastochkin, Shahriar Mobashery, Focco van den Akker, Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni. Biochemistry, 60(14), 1133-1144 (2021). [doi: 10.1021/acs.biochem.1c00027]

High ImpactCited 6 timesCristina C. Santarossa, Keith J. Mickolajczyk, Jonathan B. Steinman, Linas Urnavicius, Nan Chen, Yasuhiro Hirata, Yoshiyuki Fukase, Nicolas Coudray, Damian C. Ekiert, Gira Bhabha, Tarun M. Kapoor, Targeting allostery in the Dynein motor domain with small molecule inhibitors. Cell Chem. Biol., 28(10), 1460-1473.e15 (2021). [doi: 10.1016/j.chembiol.2021.04.024]

Cited 23 timesXiaojuan Zhou, Fengge Ma, Jun Xie, Meng Yuan, Yunqiao Li, Namir Shaabani, Fangzhu Zhao, Deli Huang, Nicholas C. Wu, Chang-Chun D. Lee, Hejun Liu, Jiali Li, Zhonghui Chen, Yazhen Hong, Wen-Hsien Liu, Nengming Xiao, Dennis R. Burton, Haijian Tu, Hang Li, Xin Chen, John R. Teijaro, Ian A. Wilson, Changchun Xiao, Zhe Huang, Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. Cell Rep., 35(6), 109109 (2021). [doi: 10.1016/j.celrep.2021.109109]

Cited 10 timesDieter Waschbüsch, Elena Purlyte, Amir R. Khan, Dual arginine recognition of LRRK2 phosphorylated Rab GTPases. Biophys. J., 120(9), 1846-1855 (2021). [doi: 10.1016/j.bpj.2021.03.030]

Cited 16 timesTim J. Wigle, Yue Ren, Jennifer R. Molina, Danielle J. Blackwell, Laurie B. Schenkel, Kerren K. Swinger, Kristy Kuplast‐Barr, Christina R. Majer, W. David Church, Alvin Z. Lu, Jason Mo, Ryan Abo, Anne Cheung, Bryan W. Dorsey, Mario Niepel, Nicholas R. Perl, Melissa M. Vasbinder, Heike Keilhack, Kevin W. Kuntz, Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule. ChemBioChem, 22(12), 2107-2110 (2021). [doi: 10.1002/cbic.202100047]

Cited 16 timesTianao Yuan, Joshua M. Werman, Xingyu Yin, Meng Yang, Miguel Garcia-Diaz, Nicole S. Sampson, Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA. ACS Infect. Dis., 7(6), 1739-1751 (2021). [doi: 10.1021/acsinfecdis.1c00069]

High ImpactCited 128 timesMarion Schuller, Galen J. Correy, Stefan Gahbauer, Daren Fearon, Taiasean Wu, Roberto Efraín Díaz, Iris D. Young, Luan Carvalho Martins, Dominique H. Smith, Ursula Schulze-Gahmen, Tristan W. Owens, Ishan Deshpande, Gregory E. Merz, Aye C. Thwin, Justin T. Biel, Jessica K. Peters, Michelle Moritz, Nadia Herrera, Huong T. Kratochvil, Anthony Aimon, James M. Bennett, Jose Brandao Neto, Aina E. Cohen, Alexandre Dias, Alice Douangamath, Louise Dunnett, Oleg Fedorov, Matteo P. Ferla, Martin R. Fuchs, Tyler J. Gorrie-Stone, James M. Holton, Michael G. Johnson, Tobias Krojer, George Meigs, Ailsa J. Powell, Johannes Gregor Matthias Rack, Victor L. Rangel, Silvia Russi, Rachael E. Skyner, Clyde A. Smith, Alexei S. Soares, Jennifer L. Wierman, Kang Zhu, Peter O’Brien, Natalia Jura, Alan Ashworth, John J. Irwin, Michael C. Thompson, Jason E. Gestwicki, Frank von Delft, Brian K. Shoichet, James S. Fraser, Ivan Ahel, Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Sci. Adv., 7(16), eabf8711 (2021). [doi: 10.1126/sciadv.abf8711]

Cited 29 timesMalligarjunan Rajavel, Vijay Kumar, Ha Nguyen, Jacob Wyatt, Steven H. Marshall, Krisztina M. Papp-Wallace, Prasad Deshpande, Satish Bhavsar, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel, Robert A. Bonomo, Focco van den Akker, Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa. mBio, 12(1) (2021). [doi: 10.1128/mBio.03058-20]

Cited 4 timesJustin D. Northrup, Jesse A. Wiener, Matthew F. D. Hurley, Chun-Feng David Hou, Taylor M. Keller, Richard H. G. Baxter, Michael J. Zdilla, Vincent A. Voelz, Christian E. Schafmeister, Metal-Binding Q-Proline Macrocycles. J. Org. Chem., 86(6), 4867-4876 (2021). [doi: 10.1021/acs.joc.1c00116]

Cited 13 timesAmit K. Gandhi, Zhen-Yu J. Sun, Walter M. Kim, Yu-Hwa Huang, Yasuyuki Kondo, Daniel A. Bonsor, Eric J. Sundberg, Gerhard Wagner, Vijay K. Kuchroo, Gregory A. Petsko, Richard S. Blumberg, Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium. Commun Biol, 4(1), 360 (2021). [doi: 10.1038/s42003-021-01871-2]

High ImpactCited 17 timesKhoa N. Pham, Ariel Lewis-Ballester, Syun-Ru Yeh, Conformational Plasticity in Human Heme-Based Dioxygenases. J. Am. Chem. Soc., 143(4), 1836-1845 (2021). [doi: 10.1021/jacs.0c09970]

Cited 17 timesNicholas J. York, Molly M. Lockart, Sinjinee Sardar, Nimesh Khadka, Wuxian Shi, Ronald E. Stenkamp, Jianye Zhang, Philip D. Kiser, Brad S. Pierce, Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center. J. Biol. Chem., 296, 100492 (2021). [doi: 10.1016/j.jbc.2021.100492]

Cited 34 timesPaul T. Marcyk, Emmanuelle V. LeBlanc, Douglas A. Kuntz, Alice Xue, Francisco Ortiz, Richard Trilles, Stephen Bengtson, Tristan M. G. Kenney, David S. Huang, Nicole Robbins, Noelle S. Williams, Damian J. Krysan, Gilbert G. Privé, Luke Whitesell, Leah E. Cowen, Lauren E. Brown, Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. J. Med. Chem., 64(2), 1139-1169 (2021). [doi: 10.1021/acs.jmedchem.0c01777]

Cited 46 timesChris A. Brosey, Jerry H. Houl, Panagiotis Katsonis, Lakshitha P.F. Balapiti-Modarage, Shobanbabu Bommagani, Andy Arvai, Davide Moiani, Albino Bacolla, Todd Link, Leslie S. Warden, Olivier Lichtarge, Darin E. Jones, Zamal Ahmed, John A. Tainer, Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog. Biophys. Mol. Bio., 163, 171-186 (2021). [doi: 10.1016/j.pbiomolbio.2021.02.002]

High ImpactCited 5 timesShukun Luo, Bruna G. Coutinho, Prikshat Dadhwal, Yasuhiro Oda, Jiahong Ren, Amy L. Schaefer, E. Peter Greenberg, Caroline S. Harwood, Liang Tong, Structural basis for a bacterial Pip system plant effector recognition protein. Proc Natl Acad Sci USA, 118(10), e2019462118 (2021). [doi: 10.1073/pnas.2019462118]

High ImpactCited 276 timesEmily Han-Chung Hsiue, Katharine M. Wright, Jacqueline Douglass, Michael S. Hwang, Brian J. Mog, Alexander H. Pearlman, Suman Paul, Sarah R. DiNapoli, Maximilian F. Konig, Qing Wang, Annika Schaefer, Michelle S. Miller, Andrew D. Skora, P. Aitana Azurmendi, Michael B. Murphy, Qiang Liu, Evangeline Watson, Yana Li, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Sandra B. Gabelli, Shibin Zhou, Targeting a neoantigen derived from a common TP53 mutation. Science, 371(6533), eabc8697 (2021). [doi: 10.1126/science.abc8697]

Cited 44 timesIsidoro Olmeda, Patricia Casino, Robert E. Collins, Ramón Sendra, Sara Callejón, Juanjo Huesa, Alexei S. Soares, Sergi Ferrer, Isabel Pardo, Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species. Microb. Biotechnol., 14(3), 1026-1043 (2021). [doi: 10.1111/1751-7915.13751]

Cited 23 timesJoseph A. Ippolito, Haichan Niu, Nicole Bertoletti, Zachary J. Carter, Shengyan Jin, Krasimir A. Spasov, José A. Cisneros, Margarita Valhondo, Kara J. Cutrona, Karen S. Anderson, William L. Jorgensen, Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead. ACS Med. Chem. Lett., 12(2), 249-255 (2021). [doi: 10.1021/acsmedchemlett.0c00612]

Amber C. Bonds, Tianao Yuan, Joshua M. Werman, Jungwon Jang, Rui Lu, Natasha M. Nesbitt, Miguel Garcia-Diaz, Nicole S. Sampson, Post-translational Succinylation of Mycobacterium tuberculosis Enoyl-CoA Hydratase EchA19 Slows Catalytic Hydration of Cholesterol Catabolite 3-Oxo-chol-4,22-diene-24-oyl-CoA. ACS Infect. Dis., 6(8), 2214-2224, PMCID: 32649175 (2020). [doi: 10.1021/ACSINFECDIS.0C00329]

Amber Crystal Bonds , Characterization of Cholesterol Catabolic Enzymes in Mycobacterium tuberculosis and Their Post-translational Regulation, Ph.D. thesis Thesis. State University of New York at Stony Brook, Stony Brook (2020).

Margarita Alexandrovna Tararina, Structural and Mechanistic Analyses of a Nicotine- Degrading Enzyme from Pseudomonas Putida: Towards Design of Tools and Biotherapeutics, Ph.D. thesis Thesis. Boston University, Boston (2020).

Cited 16 timesSophie M. Travis, Kevin DAmico, I-Mei Yu, Conor McMahon, Safraz Hamid, Gabriel Ramirez-Arellano, Philip D. Jeffrey, Frederick M. Hughson, Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1. J. Biol. Chem., 295(30), 10125-10135 (2020). [doi: 10.1074/jbc.RA120.013654]

High ImpactCited 36 timesErik H. Klontz, Chao Li, Kyle Kihn, James K. Fields, Dorothy Beckett, Greg A. Snyder, Patrick L. Wintrode, Daniel Deredge, Lai-Xi Wang, Eric J. Sundberg, Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation. Nat. Comm., 11(1), 6204 (2020). [doi: 10.1038/s41467-020-20044-z]

Cited 7 timesLina Takemaru, Gongrui Guo, Ping Zhu, Wayne A. Hendrickson, Sean McSweeney, Qun Liu, PyMDA: microcrystal data assembly using Python. J. Appl. Cryst., 53(1), 277-281 (2020). [doi: 10.1107/S160057671901673X]

Cited 19 timesTravis J Eisemann, Frederick Allen, Kelly Lau, Gregory R Shimamura, Philip D Jeffrey, Frederick M Hughson, The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation. eLIfe, 9 (2020). [doi: 10.7554/eLife.60724]

Cited 5 timesSweta Maheshwari, Yu Seon Kim, Srinivas Aripirala, Michael Murphy, L. Mario Amzel, Sandra B. Gabelli, Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase. Biochemistry, 59(29), 2751-2759 (2020). [doi: 10.1021/acs.biochem.0c00432]

High ImpactCited 18 timesAnuska Das, Travis H. Hand, Chardasia L. Smith, Ethan Wickline, Michael Zawrotny, Hong Li, The molecular basis for recognition of 5′-NNNCC-3′ PAM and its methylation state by Acidothermus cellulolyticus Cas9. Nat. Comm., 11(1), 6346 (2020). [doi: 10.1038/s41467-020-20204-1]

Cited 6 timesNicole Bertoletti, Albert H. Chan, Raymond F. Schinazi, Karen S. Anderson, Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance. Molecules, 25(20), 4868 (2020). [doi: 10.3390/molecules25204868]

High ImpactCited 24 timesChad R. Simmons, Tara MacCulloch, Fei Zhang, Yan Liu, Nicholas Stephanopoulos, Hao Yan, A Self‐Assembled Rhombohedral DNA Crystal Scaffold with Tunable Cavity Sizes and High‐Resolution Structural Detail. Angew. Chem. Int. Ed., 59(42), 18619-18626 (2020). [doi: 10.1002/anie.202005505]

High ImpactCited 9 timesTao-Hsin Chang, Fu-Lien Hsieh, Philip M. Smallwood, Sandra B. Gabelli, Jeremy Nathans, Structure of the RECK CC domain, an evolutionary anomaly. Proc Natl Acad Sci USA, 117(26), 15104-15111 (2020). [doi: 10.1073/pnas.2006332117]

Cited 39 timesEdurne Rujas, Hong Cui, Taylor Sicard, Anthony Semesi, Jean-Philippe Julien, Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Acta Cryst Sect F, 11(1), 5066 (2020). [doi: 10.1038/s41467-020-18828-4]

High ImpactCited 52 timesYonghwa Kwon, Robyn M. Kaake, Ignacia Echeverria, Marissa Suarez, Mohammad Karimian Shamsabadi, Charlotte Stoneham, Peter W. Ramirez, Jacob Kress, Rajendra Singh, Andrej Sali, Nevan Krogan, John Guatelli, Xiaofei Jia, Structural basis of CD4 downregulation by HIV-1 Nef. Nat. Struct. Mol. Biol., 27(9), 822-828 (2020). [doi: 10.1038/s41594-020-0463-z]

Cited 19 timesLinglan Fang, Jessica Vilas-Boas, Sujata Chakraborty, Zachary E. Potter, Ames C. Register, Markus A. Seeliger, Dustin J. Maly, How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture. ACS Chem. Biol., 15(7), 2005-2016 (2020). [doi: 10.1021/acschembio.0c00429]

Cited 7 timesHannah K. Margolis, Sarah Katzenell, Kelsie A. Leary, Michael J. Ragusa, The Third Coiled Coil Domain of Atg11 Is Required for Shaping Mitophagy Initiation Sites. J. Mol. Biol., 432(21), 5752-5764 (2020). [doi: 10.1016/j.jmb.2020.08.025]

High ImpactCited 134 timesZaigham M. Khan, Alexander M. Real, William M. Marsiglia, Arthur Chow, Mary E. Duffy, Jayasudhan R. Yerabolu, Alex P. Scopton, Arvin C. Dar, Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588(7838), 509-514 (2020). [doi: 10.1038/s41586-020-2760-4]

Cited 22 timesHerbert J. Bernstein, Andreas Förster, Asmit Bhowmick, Aaron S. Brewster, Sandor Brockhauser, Luca Gelisio, David R. Hall, Filip Leonarski, Valerio Mariani, Gianluca Santoni, Clemens Vonrhein, Graeme Winter, Gold Standard for macromolecular crystallography diffraction data. IUCrJ, 7(5), 784-792 (2020). [doi: 10.1107/S2052252520008672]

Cited 27 timesXiuliang Huang, Olivia P. Duddy, Justin E. Silpe, Jon E. Paczkowski, Jianping Cong, Brad R. Henke, Bonnie L. Bassler, Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway. J. Biol. Chem., 295(10), 2916-2931 (2020). [doi: 10.1074/jbc.RA119.012104]

Cited 47 timesDavid E. Heppner, Marcel Günther, Florian Wittlinger, Stefan A. Laufer, Michael J. Eck, Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J. Med. Chem., 63(8), 4293-4305 (2020). [doi: 10.1021/acs.jmedchem.0c00200]

Cited 8 timesVincent N. Duong, Joseph A. Ippolito, Albert H. Chan, Won‐Gil Lee, Krasimir A. Spasov, William L. Jorgensen, Karen S. Anderson, Structural investigation of 2‐naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29(9), 1902-1910 (2020). [doi: 10.1002/pro.3910]

High ImpactCited 21 timesAnahita Daruwalla, Jianye Zhang, Ho Jun Lee, Nimesh Khadka, Erik R. Farquhar, Wuxian Shi, Johannes von Lintig, Philip D. Kiser, Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase. Proc Natl Acad Sci USA, 117(33), 19914-19925 (2020). [doi: 10.1073/pnas.2004116117]

Cited 13 timesJohn Hill, Stuart Campbell, Gabriella Carini, Yu-Chen Karen Chen-Wiegart, Yong Chu, Andrei Fluerasu, Masafumi Fukuto, Mourad Idir, Jean Jakoncic, Ignace Jarrige, Peter Siddons, Toshi Tanabe, Kevin G Yager, Future trends in synchrotron science at NSLS-II. J. Phys.: Condens. Matter, 32(37), 374008 (2020). [doi: 10.1088/1361-648X/ab7b19]

High ImpactCited 10 timesAng Gao, Nikita Vasilyev, Abhishek Kaushik, Wenqian Duan, Alexander Serganov, Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH. Nucleic Acids Res., 48(7), 3776-3788 (2020). [doi: 10.1093/nar/gkaa024]

Cited 21 timesCarys S. Jones, David Sychantha, P. Lynne Howell, Anthony J. Clarke, Structural basis for the O-acetyltransferase function of the extracytoplasmic domain of OatA from Staphylococcus aureus. J. Biol. Chem., 295(24), 8204-8213 (2020). [doi: 10.1074/jbc.RA120.013108]

High ImpactCited 49 timesNatalie C. Bamford, François Le Mauff, Jaime C. Van Loon, Hanna Ostapska, Brendan D. Snarr, Yongzhen Zhang, Elena N. Kitova, John S. Klassen, Jeroen D. C. Codée, Donald C. Sheppard, P. Lynne Howell, Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation. Nat. Comm., 11(1), 2450 (2020). [doi: 10.1038/s41467-020-16144-5]

High ImpactCited 70 timesRajagopal Murugan, Stephen W. Scally, Giulia Costa, Ghulam Mustafa, Elaine Thai, Tizian Decker, Alexandre Bosch, Katherine Prieto, Elena A. Levashina, Jean-Philippe Julien, Hedda Wardemann, Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs. Nat Med, 26(7), 1135-1145 (2020). [doi: 10.1038/s41591-020-0881-9]

Cited 3 timesVictor G. Ruiz, Daniel J. Czyzyk, Vidya P. Kumar, William L. Jorgensen, Karen S. Anderson, Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors. BioOrg. Med. Chem., 30(16), 127292 (2020). [doi: 10.1016/j.bmcl.2020.127292]

High ImpactCited 42 timesAntony J. Burton, Michael Haugbro, Eva Parisi, Tom W. Muir, Live-cell protein engineering with an ultra-short split intein. Proc Natl Acad Sci USA, 117(22), 12041-12049 (2020). [doi: 10.1073/pnas.2003613117]

High ImpactCited 19 timesLevi J. McClelland, Kaiming Zhang, Tung-Chung Mou, Jake Johnston, Cindee Yates-Hansen, Shanshan Li, Celestine J. Thomas, Tzanko I. Doukov, Sarah Triest, Alexandre Wohlkonig, Gregory G. Tall, Jan Steyaert, Wah Chiu, Stephen R. Sprang, Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1. Nat. Comm., 11(1), 1077 (2020). [doi: 10.1038/s41467-020-14943-4]

Cited 8 timesCharles R. Midgett, Rachel A. Swindell, Maria Pellegrini, F. Jon Kull, A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts. Sci Rep, 10(1), 9002 (2020). [doi: 10.1038/s41598-020-66050-5]

High ImpactCited 53 timesPing Zhu, Xiao-Hong Yu, Cheng Wang, Qingfang Zhang, Wu Liu, Sean McSweeney, John Shanklin, Eric Lam, Qun Liu, Structural basis for Ca2+-dependent activation of a plant metacaspase. Nat. Comm., 11(1), 2249 (2020). [doi: 10.1038/s41467-020-15830-8]

High ImpactCited 44 timesForrest Z. Bowling, Christian M. Salazar, Justin A. Bell, Tahrima S. Huq, Michael A. Frohman, Michael V. Airola, Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2 and RhoA. Nat. Chem. Biol., 16(4), 400-407 (2020). [doi: 10.1038/s41589-020-0499-8]

High ImpactCited 46 timesValerie I. Khayyo, Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue, Michael V. Airola, Crystal structure of a lipin/Pah phosphatidic acid phosphatase. Nat. Comm., 11(1), 1309 (2020). [doi: 10.1038/s41467-020-15124-z]

Cited 42 timesBenjamin Stauch, Linda C. Johansson, Vadim Cherezov, Structural insights into melatonin receptors. FEBS J., 287(8), 1496-1510 (2020). [doi: 10.1111/febs.15128]

Nadia Zatsepin, S. Botha, J. Martin-Garcia, H. Hu, U. Weierstall, W. Shi, B. Andi, J. Skinner, H. Bernstein, P. Fromme, M. Fuchs, Optimizing data quality in injector-based serial millisecond crystallography. Acta Cryst Sect A, 75(a1), a384-a384 (2019). [doi: 10.1107/S0108767319096259]

High ImpactCited 20 timesMatthew McCallum, Samir Benlekbir, Sheryl Nguyen, Stephanie Tammam, John L. Rubinstein, Lori L. Burrows, P. Lynne Howell, Multiple conformations facilitate PilT function in the type IV pilus. Nat. Comm., 10(1), 5198 (2019). [doi: 10.1038/s41467-019-13070-z]

Cited 14 timesPuchong Thirawatananond, Robert Lyle McPherson, Jasmine Malhi, Sara Nathan, Michael J. Lambrecht, Matthew Brichacek, Paul J. Hergenrother, Anthony K. L. Leung, Sandra B. Gabelli, Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Sci Rep, 9(1), 5940 (2019). [doi: 10.1038/s41598-019-39491-w]

High ImpactCited 36 timesJesse B. Yoder, Manu Ben-Johny, Federica Farinelli, Lakshmi Srinivasan, Sophie R. Shoemaker, Gordon F. Tomaselli, Sandra B. Gabelli, L. Mario Amzel, Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. Nat. Comm., 10(1), 1514 (2019). [doi: 10.1038/s41467-019-09570-7]

Cited 19 timesGongrui Guo, Min Xu, Yanqi Chang, Tomas Luyten, Bruno Seitaj, Wu Liu, Ping Zhu, Geert Bultynck, Lei Shi, Matthias Quick, Qun Liu, Ion and pH Sensitivity of a TMBIM Ca2+ Channel. Structure, 27(6), 1013-1021.e3 (2019). [doi: 10.1016/j.str.2019.03.003]

Wuxian Shi, Two new beamlines at NSLS-II for micro-focus, serial and highly automated macromolecular crystallography. Acta Cryst Sect A, 75(a1), a231-a231 (2019). [doi: 10.1107/S0108767319097721]

Cited 10 timesJeremy D. Osko, Benjamin W. Roose, Stephen A. Shinsky, David W. Christianson, Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth Halophile Marinobacter subterrani. Biochemistry, 58(36), 3755-3766 (2019). [doi: 10.1021/acs.biochem.9b00582]

Cited 33 timesJustin T. Cruite, Gabriela Kovacikova, Kenzie A. Clark, Anne K. Woodbrey, Karen Skorupski, F. Jon Kull, Structural basis for virulence regulation in Vibrio cholerae by unsaturated fatty acid components of bile. Commun Biol, 2(1), 440 (2019). [doi: 10.1038/s42003-019-0686-x]

Cited 6 timesD.J. Czyzyk, M. Valhondo, L. Deiana, J. Tirado-Rives, W.L. Jorgensen, K.S. Anderson, Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur. J. Med. Chem., 183, 111673 (2019). [doi: 10.1016/j.ejmech.2019.111673]

High ImpactCited 11 timesS Travis, B Kokona, R Fairman, F Hughson, Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering. Proc Natl Acad Sci USA, 116(48), 24031-24040 (2019). [doi: 10.1073/pnas.1909697116]

Cited 23 timesC Herbst-Gervasoni, D Christianson, Binding of N-8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58(49), 4957-4969 (2019). [doi: 10.1021/acs.biochem.9b00906]

Cited 19 timesM Miller, J Douglass, M Hwang, A Skora, M Murphy, N Papadopoulos, K Kinzler, B Vogelstein, S Zhou, S Gabelli, An engineered antibody fragment targeting mutant β-catenin via Major Histocompatibility . J. Biol. Chem., 294(50), 19322-19334 (2019). [doi: 10.1074/jbc.RA119.010251]

Cited 25 timesO Velásquez-González, C Campos-Escamilla, A Flores-Ibarra, N Esturau-Escofet, R Arreguin-Espinosa, V Stojanoff, M Cuéllar-Cruz, A Moreno, Crystal Growth in Gels from the Mechanisms of Crystal Growth to Control of Polymorphism: New Trends on Theoretical and Experimental Aspects . Crystals, 9(9), 443 (2019). [doi: 10.3390/cryst9090443]

High ImpactCited 36 timesM Choy, T Moon, R Ravindran, J Bray, L Robinson, T Archuleta, W Shi, W Peti, K Tatchell, R Page, SDS22 selectively recognizes and traps metal-deficient inactive PP1. Proc Natl Acad Sci USA, 116(41), 20472-20481 (2019). [doi: 10.1073/pnas.1908718116]

High ImpactCited 36 timesJ Maianti, G Tan, A Vetere, A Welsh, B Wagner, M Seeliger, D Liu, Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nat. Chem. Biol., 15, 565 (2019). [doi: 10.1038/s41589-019-0271-0]

Cited 25 timesC Mayo, H Erlandsen, D Mouser, A Feinstein, V Robinson, E May, J Cole, Structure basis of protein kinase R autophosphorylation. Biochemistry, 58, 2967-2977 (2019). [doi: 10.1021/acs.biochem.9b00161]

Cited 8 timesN Khadka, E Farquhar, H Hill, W Shi, J von Lintig, P Kiser, Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J. Biol. Chem., 294(27), 10596-10606 (2019). [doi: 10.1074/jbc.RA119.007535]

Cited 16 timesB Roose, D Christianson, Structural Basis of Tryptophan Reverse N-Prenylation Catalyzed by CymD. Biochemistry, 58(30), 3232-3242 (2019). [doi: 10.1021/acs.biochem.9b00399]

Cited 21 timesM Janco, M Rynkiewicz, L Li, J Hook, E Eiffe, A Ghosh, T Bocking, W Lehman, E Hardeman, P Gunning, Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1. Sci Rep, 9, 11262 (2019). [doi: 10.1038/s41598-019-47592-9]

High ImpactCited 39 timesB Stadinski, S Blevins, N Spidale, B Duke, P Huseby, L Stern, E Huseby, A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+ Treg cell development. Nat. Immunol., 20, 1046-1058 (2019). [doi: 10.1038/s41590-019-0414-1]

Cited 18 timesN Bertoletti, A Chan, R Schinazi, Y Yin, K Anderson, Structural insights into the recognition of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) by HIV‐1 reverse transcriptase: First crystal structures with RT and the active triphosphate forms of lamivudine and emtricitabine. Protein Sci., 28(9), 1664-1675 (2019). [doi: 10.1002/pro.3681]

Cited 15 timesG Guo, P Zhu, M Fuchs, W Shi, B Andi, Y Gao, W Hendrickson, S McSweeney, Q Liu, Synchrotron microcrystal native-SAD phasing at a low energy. IUCrJ, 6(4), 532-542 (2019). [doi: 10.1107/S2052252519004536]

Cited 16 timesB Zeng, T Mou, T Doukov, A Steiner, W Yu, M Papasergi-Scott, G Tall, F Hagn, S Sprang, Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A. Structure, 27(7), 1137-1147 (2019). [doi: 10.1016/j.str.2019.04.013]

High ImpactCited 332 timesK Biegasiewicz, S Cooper, X Gao, D Oblinsky, J Kim, S Garfinkle, L Joyce, B Sandoval, G Scholes, T Hyster, Photoexcitation of flavoenzymes enables a stereoselective radical cyclization. Science, 364(6446), 1166-1169 (2019). [doi: 10.1126/science.aaw1143]

High ImpactCited 11 timesR Pisa, T Cupido, T Kapoor, Designing Allele-Specific Inhibitors of Spastin, a Microtubule-Severing AAA Protein. J. Am. Chem. Soc., 141(14), 5602-5606 (2019). [doi: 10.1021/jacs.8b13257]

Cited 41 timesJ Paczkowski, A McCready, J Cong, P Jeffrey, C Smith, F Hughson, B Henke, B Bassier, An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. ACS Chem. Biol., 14(3), 378-389 (2019). [doi: 10.1021/acschembio.8b00971]

Cited 11 timesM Miller, S Maheshwari, W Shi, Y Gao, N Chu, A Soares, P Cole, L Amzel, M Fuchs, Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II. Molecules, 24(3), 496 (2019). [doi: 10.3390/molecules24030496]

Cited 46 timesS Luo, K Xu, S Xiang, J Chen, C Guo, Y Tong, L Tong, High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Cryst Sect F, 74(Pt 11), 717-724, PMCID: PMC6213978 (2018). [doi: 10.1107/S2053230X18012955]

High ImpactCited 38 timesA Peselis, A Serganov, ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands. Nat. Chem. Biol., 14(9), 887-894, PMCID: PMC6263941 (2018). [doi: 10.1038/s41589-018-0114-4]

High ImpactCited 15 timesA Gao, N Vasilyev, D Luciano, R Levenson-Palmer , J Richards, W Marsiglia, N Traaseth, J Belasco, A Serganov, Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF. Nucleic Acids Res., 46(13), 6841, PMCID: PMC6061855 (2018). [doi: 10.1093/nar/gky327]

Cited 31 timesE Choi, S Suh, C Sander, C Hernandez, E Bulman, N Khadka, Z Dong, W Shi, K Palczewski, P Kiser, Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum. Mol. Genet., 27(13), 2225-2243 (2018). [doi: 10.1093/hmg/ddy128]

High ImpactCited 123 timesN Chu, A Salguero, A Liu, Z Chen, D Dempsey, S Ficarro, W Alexander, L Amzel, S Gabelli, P Cole, Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell, 174, 897-907 (2018). [doi: 10.1016/j.cell.2018.07.003]

E Nazaretski, W Xu, H Yan, X Huang, D Coburn, M Ge, W Lee, Y Gao, M Fuchs, Y Chu, Microscopy Instrumentation and Nano-Positioning at NSLS-II: Current Status and Future Directions. Synch. Rad. News, 31(5), 3-8 (2018). [doi: 10.1080/08940886.2018.1506233]

High ImpactCited 155 timesJ Yang, Z Liu, C Wang, R Yang, J Rathkey, O Pinkard, W Shi, Y Chen, G Dubyak, Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci USA, 115(26), 6792-6797 (2018). [doi: 10.1073/pnas.1800562115]

Cited 47 timesN Porter, F Wagner, D Christianson, Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6. Biochemistry, 57(26), 3916-3924 (2018). [doi: 10.1021/acs.biochem.8b00367]

High ImpactCited 64 timesD Lin, A Correia, S Cai, F Huber, C Jette, A Hoelz, Structural and Functional Analysis of mRNA Export Regulation by the Nuclear Pore Complex. Nat. Comm., 9(2319) (2018). [doi: 10.1038/s41467-018-04459-3]

Cited 20 timesY Gao, W Xu, W Shi, A Soares, J Jakoncic, S Myers, B Martins, J Skinner, Q Liu, High-speed raster-scanning synchrotron serial microcrystallography with a high-precision piezo-scanner. J. Synch. Rad., 25(5), 1362-1370 (2018). [doi: 10.1107/S1600577518010354]

Cited 32 timesG Guo, M Fuchs, W Shi, J Skinner, E Berman, C Ogata, W Hendrickson, S McSweeney, Q Liu, Sample manipulation and data assembly for robust microcrystal synchrotron crystallography. IUCrJ, 5, 238-246 (2018). [doi: 10.1107/S2052252518005389]

High ImpactCited 83 timesY Bi, E Mann, C Whitfield, J Zimmer, Architecture of a channel-forming O-antigen polysaccharide ABC transporter . Nature, 553, 361–365 (2018). [doi: 10.1038/nature25190]

D Bhogadi, B Andi, L Berman, M Carlucci-Dayton, M Fuchs, J Jakoncic, T Langdon, J Lara, B Martins, Design, Construction and Commissioning of Two Highly Integrated Experimental Stations for Micro-Focusing Macromolecular Crystallography Beamlines at NSLS-II, Mechanical Engineering Design of Synchrotron Radiation Equipment and Instrumentation Conference 2016, p. 363-366, sponsored by ALBA Synchrotron Light Source (2017). [doi: 10.18429/JACoW-MEDSI2016-WEPE36]

H Bernstein, B Andi, K Badalian, L Berman, D Bhogadi, S Chodankar, J DiFabio, M Fuchs, J Jakoncic, Computing Infrastructure, Software Optimization, and Real Time Analysis for High Data-rate MX, Scientific Data Summit (NYSDS), 2016 New York, p. 1-4, sponsored by IEEE (2016). [doi: 10.1109/NYSDS.2016.7747828]

Cited 15 timesM Fuchs, D Bhogadi, J Jakoncic, S Myers, R Sweet, L Berman, J Skinner, M Idir, O Chubar, NSLS-II Biomedical Beamlines for Micro-crystallography, FMX, and for Highly Automated Crystallography, AMX: New Opportunities for Advanced Data Collection, 12TH INTERNATIONAL CONFERENCE ON SYNCHROTRON RADIATION INSTRUMENTATION - SRI2015, Vol 1741, p. 030006, sponsored by National Synchrotron Light Source II (2016). [doi: 10.1063/1.4952829]

M Fuchs, R Sweet, L Berman, D Bhogadi, W Hendrickson, O Chubar, L Yang, S McSweeney, D Schneider, NSLS-II MX Beamlines FMX for Micro-crystallography & AMX for Highly Automated MX. Acta Cryst. A, A70, C1733 (2014).

M Fuchs, R Sweet, L Berman, W Hendrickson, O Chubar, N Canestrari, M Idir, L Yang, D Schneider, NSLS-II Biomedical Beamlines for Macromolecular Crystallography, FMX and AMX, and for X-ray Scattering, LIX: Current Developments. J Phys.: Conf. Ser., 493, 012021 (2014).

L Yang, D Schneider, M Fuches, L Berman, Current Status of ABBIX Beamlines Developed for X-Ray Scattering and Macromolecular Crystallography at NSLS-II. Biophys. J., 106(2), 384a (2014).

D Schneider, L Berman, O Chubar, W Hendrickson, S Hulbert, M Lucas, R Sweet, L Yang, Three Biomedical Beamlines at NSLS-II for Macromolecular Crystallography and Small-Angle Scattering. J Phys.: Conf. Ser., 425, 012003 (2013).