Frontier Microfocusing Macromolecular Crystallography
Science Highlights
Scientists Find a New Way to Help Plants Fight Diseases
Friday, May 30, 2025
Scientists have documented the structures and regulation mode for a protein that can help plants combat disease.
New Class of RAS Inhibitors Could Treat Many Cancers
Saturday, November 30, 2024
Researchers describe the RAS(ON) multi-selective inhibitor RMC-7977, which targets the frequently mutated RAS oncogenes in tumors.
Pinning Down a Piece of Photosynthesis
Tuesday, June 18, 2024
Researchers have new insights into how Synechocystis, a cyanobacteria, cycles carbon in changing conditions.
Halting Viral RNA Replication in Coronaviruses
Wednesday, June 14, 2023
Scientists find the crystal structure of the C-terminal domain of SARS-CoV-2 nonstructural protein 3, necessary for replication.
How Do Algae Survive Under Low Light Conditions?
Wednesday, December 14, 2022
Scientists show the mechanism behind low light adaptation in algae.
The Emergence of Form: Study Expands Horizons for DNA Nanotechnology
Monday, October 3, 2022
In a new study, researchers explore a basic building block used in the fabrication of many DNA nanoforms.
First Structure of Key COVID Enzyme at Human Body Temperature
Tuesday, August 16, 2022
Subtle structural changes in virus’s “main protease” over a range of temperatures may point to new targets for antiviral drugs.
Oral & Gut Microbes Can Inactivate an Antidiabetic Drug
Thursday, March 31, 2022
Scientists found that an unanticipated interaction may occur between the human microbiome and a drug against diabetes
Lowering the Survival Chance of Bacteria
Friday, December 31, 2021
Scientists discovered a new way to boost the potency of existing antibiotics.
Oral and Gut Microbes Can Inactivate an Antidiabetic Drug, Princeton Scientists Find
Tuesday, December 28, 2021
Researchers found that some bacteria in the mouth and gut can inactivate acarbose, a commonly prescribed antidiabetic drug, and how another enzyme can prevent this.
Researchers Discover Critical Role of Hydrogen Sulfide in Ability of Bacteria to Survive Antibiotics
Monday, December 27, 2021
The signaling molecule hydrogen sulfide (H2S) plays a critical role in antibiotic tolerance, a new study finds.
Fighting Cancer with a New Antibody
Wednesday, June 30, 2021
Mutant Gene-Targeted approach offers potential to broadly expand the benefit of immunotherapies.
Massive Fragment Screen Points Way to New SARS-CoV-2 Inhibitors
Friday, May 7, 2021
Experiment with 2533 fragments compounds generates chemical map to future antiviral agents.
Fine Tuning Drugs to Fight Cancer
Monday, November 30, 2020
Scientists reveal, for the first time, how the drug Trametinib binds itself to its target.
Steady Progress in the Battle Against COVID-19
Wednesday, October 7, 2020
Update on Brookhaven Lab’s research efforts aimed at thwarting the novel SARS-CoV-2 virus responsible for a global pandemic
Understanding an Essential Chaperone Complex
Wednesday, September 30, 2020
Scientists reveal a protein binding mechanism that is connected to embryo development and cancer
Revealing the Basis for Metacaspase Activation
Friday, July 31, 2020
Scientists reveal a critical activation mechanism that offers a pathway for more sustainable crops and biofuels.
Inside Brookhaven National Lab's COVID-19 Quest
Wednesday, May 20, 2020
Newsday Opinion video documents Brookhaven Lab scientists’ around-the-clock efforts to map and halt the coronavirus
Brookhaven Lab Mobilizes Resources in Fight Against COVID-19
Monday, April 6, 2020
Brookhaven Lab scientists and staff combine expertise across disciplines and use Lab’s unique facilities to address drug development, medical supplies, information processing, and more
Inhibitor or Activator: Why not Both?
Friday, January 31, 2020
Scientists discovered how a protein that plays an important role in various diseases multitasks
Light Teaches (Co)Enzymes New Tricks
Wednesday, July 31, 2019
Scientists investigated the reaction of a specific class of enzymes to light.
New Approach for Solving Protein Structures from Tiny Crystals
Friday, May 3, 2019
New technique opens the door for studies of countless hard-to-crystallize proteins involved in health and disease.
Kinase Activation Mechanism Could Help Cancer Research
Thursday, January 31, 2019
Scientists investigate the activation mechanism of Akt 1 protein kinase to understand its role in cancer proliferation
Structure of a Nuclear Pore Complex's "Ticket System"
Tuesday, July 31, 2018
Scientists revealed the 3D structure of “gatekeeper” proteins for which failure is associated with many diseases.
New High-Precision Instrument Enables Rapid Measurements of Protein Crystals
Tuesday, May 29, 2018
Scientists developed a new goniometer scanner system for ultra-fast and efficient serial protein crystallography at the National Synchrotron Light Source II.
Scientists Reveal Novel Architecture of a Membrane Protein
Saturday, March 31, 2018
Scientists used x-ray crystallography to reveal a crystal structure for an O-antigen transporter and found an unexpected channel-forming conformation.
