Highly Automated Macromolecular Crystallography
Science Highlights
Small-Molecule Binding and Sensing through AI-Driven Protein Design
Wednesday, December 11, 2024
Researchers used deep-learning tools to design proteins capable of binding and sensing diverse small molecules with high precision.
An AI-Based Biomolecular Structure Prediction & Design Tool
Monday, September 30, 2024
Researchers developed a protein structure prediction & design tool, and experimentally validated its designs.
Pinning Down a Piece of Photosynthesis
Tuesday, June 18, 2024
Researchers have new insights into how Synechocystis, a cyanobacteria, cycles carbon in changing conditions.
New Approach to Tackling Bacterial Infections Identified
Tuesday, February 13, 2024
Researchers have found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections.
How Do Algae Survive Under Low Light Conditions?
Wednesday, December 14, 2022
Scientists show the mechanism behind low light adaptation in algae.
Using Enzymes to Selectively Form C-C Bonds
Wednesday, October 12, 2022
Scientists find a new way to rapidly construct molecules for possible applications in the pharmaceutical and agrochemical industries.
The Emergence of Form: Study Expands Horizons for DNA Nanotechnology
Monday, October 3, 2022
In a new study, researchers explore a basic building block used in the fabrication of many DNA nanoforms.
Oral & Gut Microbes Can Inactivate an Antidiabetic Drug
Thursday, March 31, 2022
Scientists found that an unanticipated interaction may occur between the human microbiome and a drug against diabetes
Lowering the Survival Chance of Bacteria
Friday, December 31, 2021
Scientists discovered a new way to boost the potency of existing antibiotics.
Oral and Gut Microbes Can Inactivate an Antidiabetic Drug, Princeton Scientists Find
Tuesday, December 28, 2021
Researchers found that some bacteria in the mouth and gut can inactivate acarbose, a commonly prescribed antidiabetic drug, and how another enzyme can prevent this.
Researchers Discover Critical Role of Hydrogen Sulfide in Ability of Bacteria to Survive Antibiotics
Monday, December 27, 2021
The signaling molecule hydrogen sulfide (H2S) plays a critical role in antibiotic tolerance, a new study finds.
Fighting Cancer with a New Antibody
Wednesday, June 30, 2021
Mutant Gene-Targeted approach offers potential to broadly expand the benefit of immunotherapies.
Massive Fragment Screen Points Way to New SARS-CoV-2 Inhibitors
Friday, May 7, 2021
Experiment with 2533 fragments compounds generates chemical map to future antiviral agents.
Fine Tuning Drugs to Fight Cancer
Monday, November 30, 2020
Scientists reveal, for the first time, how the drug Trametinib binds itself to its target.
Steady Progress in the Battle Against COVID-19
Wednesday, October 7, 2020
Update on Brookhaven Lab’s research efforts aimed at thwarting the novel SARS-CoV-2 virus responsible for a global pandemic
Revealing the Basis for Metacaspase Activation
Friday, July 31, 2020
Scientists reveal a critical activation mechanism that offers a pathway for more sustainable crops and biofuels.
Inside Brookhaven National Lab's COVID-19 Quest
Wednesday, May 20, 2020
Newsday Opinion video documents Brookhaven Lab scientists’ around-the-clock efforts to map and halt the coronavirus
Brookhaven Lab Mobilizes Resources in Fight Against COVID-19
Monday, April 6, 2020
Brookhaven Lab scientists and staff combine expertise across disciplines and use Lab’s unique facilities to address drug development, medical supplies, information processing, and more
LI High School Students Solve Protein Structures at Brookhaven's Light Source
Wednesday, December 18, 2019
Knowledge gained at world-class research facility could open doors to new treatments for diseases and advance careers of young scientists
A Structural Understanding of Spore Germination
Saturday, November 30, 2019
This new insight about spore germination can help scientists to improve disinfection.
Light Teaches (Co)Enzymes New Tricks
Wednesday, July 31, 2019
Scientists investigated the reaction of a specific class of enzymes to light.
Searching for New Ways to Fight Bacterial Resistance
Sunday, March 31, 2019
Scientists investigate the inhibition of rifamycin derivatives on mycobacteria RNA polymerase
Kinase Activation Mechanism Could Help Cancer Research
Thursday, January 31, 2019
Scientists investigate the activation mechanism of Akt 1 protein kinase to understand its role in cancer proliferation
3D Protein Structure Helps in the Search for a Vaccine
Thursday, May 31, 2018
Scientists revealed the 3D structure of a protein that plays a major role in the fusion process between human cells and the human metapneumovirus to which it belongs.
Scientists Reveal Novel Architecture of a Membrane Protein
Saturday, March 31, 2018
Scientists used x-ray crystallography to reveal a crystal structure for an O-antigen transporter and found an unexpected channel-forming conformation.
