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Shih-Ting (Christine) Wang

Research Associate | Soft and Bio Nanomaterials

Expertise

  • Programmable Self-assembly of Biomaterials and Nanomaterials
  • Biomedical Applications of Nanomaterials
  • Bioconjugation chemistry
  • Chemical, Biochemical and Electron Microscopic Analyses of Nanoscale Materials

CFN Research Activities

My research aims to transfer synthetic DNA nanostructures into biologically relevant carriers and platforms, for biomedical applications including protein arrays, cellular targeting and drug delivery. Specially I investigate the sequence-structure relationships, and engineer the interface of peptide and protein based biomolecules with DNA to generate hybrid structures and novel biomaterials.

Education

B.S. in Materials Science and Engineering: National Cheng Kung University, Taiwan

  • Independent project: Effect of ethanolamine to the sol-gel mechanism of zinc oxide thin film formation

M.S. in Materials Science and Engineering: National Cheng Kung University, Taiwan

  • Dissertation title: Photoluminescence of solvothermal reduced graphene oxide with surface decoration by silver nanoparticles

PhD in Materials Science: Imperial College London, United Kingdom

  • Thesis title: Investigating Type 2 Diabetes Related Biosensing and Amyloid Peptide Fibrillation

Professional Appointments

Research Associate: Brookhaven National Laboratory

  • Center for Functional Nanomaterials
  • Project: DNA origami nanostructures for self-organized protein arrays and nanomedicine

Selected Publications & Research Highlights

  • S. –T. Wang, S. Xuan, M. A. Gray, Y. Lin, A. I. Nguyen, N. Todorova, M. M. Stevens, C. R. Bertozzi, R. N. Zuckermann, O. Gang, DNA Origami Protection and Molecular Interfacing Through Engineered Sequence-Defined Peptoids, Proc. Natl. Acad. Sci. 117, 6339-6348 (2020). [DOI: 10.1073/pnas.1919749117]
  • S. -T. Wang, Y. Lin, M. H. Nielsen, C. Song, M. R., C. D. Spicer, P. Ercius, S. Aloni, M. M. Stevens, Shape-Controlled Synthesis and In-Situ Characterisation of Anisotropic Au Nanomaterials using Liquid Cell Transmission Electron Microscopy, Nanoscale, 11, 16801-16809 (2019). [DOI: 10.1039/C9NR01474H]
  • S. -T. Wang, Y. Lin, R. K. Spencer, A. I. Nguyen, M. R. Thomas, N. Amdursky, E. T. Pashuck, S. C. Skaalure, C. Song, P. A. Parmar, R. M. Morgan, P. Ercius, S. Aloni, R. N. Zukermann, M. M. Stevens, Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide Derived β-Sheet Fibrils, ACS Nano, 11, 8579–8589 (2017). [DOI: 10.1021/acsnano.7b02325]
  • Shih-Ting Wang, Y. Lin, N. Todorova, Y. Xu, M. Mazo, S. Rana, V. Leonardo, C. D. Spicer, A. A. Edwards, B. Alexander, S. J. Matthews, I. Yarovsky, M. M. Stevens, Facet Dependent Islet Amyloid Polypeptide Interactions with Gold Nanoparticles: Implications for Fibril Formation and Peptide Induced Lipid Membrane Disruption, Chem. Mat. 29, 1550-1560 (2017). [DOI: 10.1021/acs.chemmater.6b04144]
  • S. -T. Wang, Y. Lin, C. -C. Hsu, C. D. Spicer, M. M. Stevens, Probing Amylin Fibrillation at the Early Stage via a Tetracysteine-Targeting Fluorophore, Talanta, 173, 44-50 (2017). [DOI: 10.1016/j.talanta.2017.05.015]
  • S. -T. Wang, Y. Lin, C. D. Spicer, M. M. Stevens, Bio-Inspired Maillard-Like Reactions Enable a Simple and Sensitive Assay for Colorimetric Detection of Methylglyoxal, Chem. Commun. 51, 11026-11029 (2015). [DOI: 10.1039/C5CC02590G]

ORCID: https://orcid.org/0000-0002-7634-8332