Dr. Tkachenko works on a variety of problems in Theoretical Soft Condensed Matter, with special focus on programmable self-assembly and biologically-inspired nanotechnology. In particular, he is one of the pioneers of theoretical studies of DNA/nanoparticle and DNA/colloidal systems. The strategic objective of this research is to use the highly specific bimolecular interactions (e.g. between complementary DNA) for programmable nano-architecture, and for design of functional nanostructures. Much of this research is done in close collaboration with CFN Soft/Bio Nanomaterals group, as well as with CFN user community.
A. V. Tkachenko, "Theory of Programmable Hierarchic Self-Assembly," Phys. Rev. Lett. 106 (25), 255501 (2011).
F. J. Martinez-Veracoechea, B. M. Mladek, A. V. Tkachenko, and D. Frenkel, "Design Rule for Colloidal Crystals of DNA-Functionalized Particles," Phys. Rev. Lett. 107(4), 045902 (2011)
R. Dreyfus, M. E. Leunissen, Roujie Sha, A.V. Tkachenko, N. C. Seeman, D.J. Pine, and P. M. Chaikin, "Simple Quantitative Model for the Reversible Association of DNA Coated Colloids", Phys. Rev. Lett. 102, 048301 (2009)
N. A. Licata and A. V. Tkachenko.,”Kinetic Limitations of Cooperativity-Based Drug Delivery Systems”, Phys. Rev. Lett. 100:158102 (2008). N. A. Licata and A. V. Tkachenko. "Statistical mechanics of DNA-mediated colloidal aggregation", Phys. Rev. E 74, 041408 (2006)